Title: HUMAN BIOLOGY
1HUMAN BIOLOGY
2WHY?
- To learn about ourselves, our culture
- To learn the relationship between form function
- Study the parts to understand the whole body
- To become familiar with terminology that
describes the structures processes associated
with the human body
3CULTURE the reasons for it
- CULTURE Social influences human behavior
- Why is culture important?
- To learn from the experiences of others
- Its carried on through language big brains
- Its faster acting easier to observe than the
evolution of anatomy physiology
4WHAT IS BIOLOGY?
- Biology comes from the Greek
- Bios life
- Logos to study
- Biology is the study of life!
5What Is the Meaning Of Life?Top 7 ways to tell
the living from the nonliving
- 1 Cellular Organization
- 2 Reproduction
- 3 Metabolism
- 4 Homeostasis
- 5 Heredity
- 6 Responsiveness
- 7 Able to Grow Develop
6If It Does NOT meet ALL 7
7CELLULAR ORGANIZATION
- All living things are made up of 1 or more cells
- Cells smallest unit capable of all life
functions
8REPRODUCTION
- How all life forms make more of their own kind
from 1 generation to the next - All living things (ORGANISMS) can reproduce
9METABOLISM
- Sum of all chemical reactions in an organism
- Chemistry is necessary for life!
- Balancing those chemical reactions
HOMEOSTASIS
10HOMEOSTASIS
- The ability to maintain a relatively constant
internal environment (at all levels of body
organization) despite changes in the outside
environment
11EXAMPLES of HOMEOSTASIS
- Body temperature
- Water-mineral balance
- Blood pressure
- Sleep-wake cycle
- Blood pH
- Any physiological process with a
negative-feedback system of control
12Why Is Homeostasis Such A Big Deal?
- Physiological processes can function only under a
limited range of conditions - Goldilocks factor
- EX--- Body temperature
- 98.6º F or 37º C
13HEREDITY
- All organisms pass on traits from parent to
offspring - GENES sets of inherited instructions for making
proteins - MUTATION any change in a gene (DNA)
- DNA code on genes for making proteins
14RESPONSIVENESS(irritability)
- 1 Detect information about the environment
- 2 Process this information
- 3 Respond appropriately
15GROWTH DEVELOPMENT
- GROWTH replace worn out cells
increase in size - DEVELOPMENT advance, fulfill with time
- mature
16METABOLISM
- Sum of all chemical reactions within living cells
- catabolism ?? anabolism
- Catabolism break down
- (digest food into protein)
- Anabolism build up
- (rearrange proteins into new cells)
17CELLS
- Functional structural building block of life
- This makes them the
- SMALLEST LIVING THINGS!
18CELLS HAVE 3 THINGS IN ALL COMMON
- Made of Cytoplasm Nucleus enclosed by a Cell
Membrane - Cytoplasm fluid in a cell
- Nucleus cells control center, brain
- Cell Membrane outermost part of a cell,
- the cells skin
19The Order of Perspectives on Human Biology (HB)
- 1 Atoms
- 2
Molecules - 3
Organelles - 4 Cells
- 5 Tissues
- 6 Organs
- 7 Organ
systems - 8
OrganismsYOU! - 9
Populations - 10
Ecosystem - 11
Biosphere
small
big
20The Order of Perspectives on Human Biology (HB)
- 1 Atoms
- 2
Molecules - 3
Organelles - ---------------------------- 4 Cells
----------------------------------- - 5 Tissues
- 6 Organs
- 7 Organ
systems - 8
OrganismsYOU! - 9
Populations - 10
Ecosystem - 11
Biosphere
NOT ALIVE!
ITS VERY ALIVE!
21HUMAN BIOLOGY IS EVERYWHERE!
- Internet
- Magazines
- TV News
- Newspapers
- Books
22HUMAN BIOLOGY IS EVERDAY INVOLVING EVERYONE!
- Cloning
- Human Genome Project (HUGO)
- Curing AIDS
- Saving the rainforest
- Genetic engineering to cure genetic diseases
- EX- MS, CF, Dyslexia, Diabetes, Some cancers
23HUMAN BIOLOGY IS EVERBODY!
- In 1999, world population exceeded 6 billion!
- Not enough space, food, energy, resources for
everyone is a very SERIOUS problem.
24RAINFORESTS HUMANS
- Destroying rainforests to make space to live
affects plants animals - Half of the worlds species live in the
rainforests - Tropical rainforests are currently being
destroyed at a rate greater than 1 acre/ second! - At this rate, the last tree will fall by 2050!
25RAINFORESTS HUMANS
- This will destroy over 1 million species, making
it the greatest extinction since the dinosaurs of
65 million years ago! - Who knows what potential medicines, foods,
plastics, and genetic material we are losing? - Biologists seek balance between the need for land
protecting ALL life.
26MORE PEOPLE MEANS MORE FOOD IS NEEDED
- Biologists seek new crops to grow more
efficiently in tropical soils without too much
fertilizer or pesticides - Genetic engineers place plant genes into other
plants to form new crops that are germs insect
resistant AND bear fruit many times a year! - EX- New crops are frost resistant due to inserted
genes - Insect resistant crops decrease the amount of
bug spray used (saves )
27HUMAN BIOLOGISTS SEEK CURES
- AIDS
- Cancer
- CF (cystic fibrosis)
- MS (multiple sclerosis)
- MD (muscular dystrophy)
- Diabetes
- Heart Problems (cardiopathies)
- Many others
28AIDS
- Acquired Immunodeficiency Syndrome
- Since 1981 (when 1st recognized) 50 million
people have been infected - 14 million already dead, 2 million die per year
- Caused by HIV Human Immunodeficiency Virus
- It is an STD, also spread by other body fluids
- NOT including urine (pee) , feces (poop) sweat.
29HUMAN BIOLOGISTS SEEK CURES
- Yes, AIDS-like diseases also affect other animals
- FIV Feline Immunodeficiency Virus
- FIV ONLY affects cats
- It is highly contagious among cats
- FIV is curable
- Humans do not catch it.
- Some forms of HIV can spread to other primates
(chimps, monkeys, bonobos, etc.)
30CANCER
- Cellular growth disorder
- When cells do not know when to stop reproducing
- Can be prematurely set off by chemicals
- (esp. in tobacco)
- Many human cancers are know curable, thanks to
HUGO (HUman GenOme project) - We will see this in detail in later chapters
31CF
- Cystic Fibrosis
- Fatal disorder in which abnormally thick mucus
builds up in many organs, esp. the lungs - Too much mucus, not enough breathing
- Caused by a defective gene
- Researchers try to treat fatal CF with
- GENE THERAPY
32GENE THERAPY
- Gene therapy replacing a defective genes with a
healthy, normal one - This treatment is used by GENETIC ENGINEERS
sometimes called GENE THERAPISTS. - This treatment may 1 day cure most genetic
diseases, like CF, MS, MD, diabetes, dyslexia. - The difficulty is not finding healthy genes, but
introducing the normal genes into defective DNA.
331-2 REVIEW
- 1 Human Biology is a large part of everday life
- 2 Addressing a growing human population,
environmental damage, human disease demand an
answer we are gradually finding.
34HOW IS HUMAN BIOLOGY STUDIED?
- Scientific Method
- 1 Observation --- using the 5 senses
- 2 Hypothesis---educated guess
- 3 Prediction that is falsifiable (can be proven
wrong) - Test (Experiment)
- Conclusion
35OBSERVATION
- Native American peoples today have smaller teeth
than the skulls of the same peoples 2000 years
ago.
36HYPOTHESIS
- Native American peoples needed larger teeth to
eat grains and unprocessed foods before industry
entered the USA and made other foods easier to
obtain.
37PREDICTION
- IF the hypothesis is TRUE
- Comparing teeth measurements on the skulls of
ancient Shawnees to those of modern Shawnees on
OK reservations will prove that the modern teeth
are smaller. - IF the hypothesis is NOT TRUE
38TEST
- Perform an EXPERIMENT
- Experiment test to prove or disprove a
hypothesis - Apply the comparative method to the Sioux,
Iroquois, or Chickasaw Tribes. - Ask Why are the Shawnee different? if they
prove to differ in teeth size compared to other
tribes. - Research Shawnee diet and eating habits.
39CONCLUSION
- Evidence from the experiment either does or does
not support the hypothesis. - In the comparative teeth experiment
- The evidence actually does support the
hypothesis. - From this we could form a CONCLUSIVE STATEMENT
40CONCLUSIVE STATEMENT
- Comparing teeth size in 2000 year old Shawnees to
the modern day Shawnee proves that Shawnee teeth
have gotten smaller.
41Example of the Scientific Method
- Observation Eating red grapes induces labor in
rats - Hypothesis Caused by an agent in red grapes
- Prediction If the hypothesis is true, then
pregnant rats given red grape juice (experimental
treatment) will go into labor before rats given
white grape juice (control treatment) go into
labor. - Test Do the experiment
- Conclusion Based on the results of the experiment
42THEORY LAW
- THEORY explanation based on a set of related
hypotheses that have been tested confirmed many
times - EX- Theory of Evolution
- LAW theory or a set of theories generally
accepted as scientifically true accurate - Some theories are so strongly supported that
likelihood of their being rejected in the future
is small - EX Law of Gravity
43SCIENTIFIC TRUTH
- SCIENTIFIC TRUTH
- There is no absolute certainty in a
scientific theory. The possibility always
remains that future evidence will cause a
scientific theory to be revised or rejected. A
scientists acceptance of a theory is always
provisional. - EC- Define FAITH
44ATOMS
- Smallest units of matter
- Cannot be broken down further by chemical means
- Made of 3 subatomic particles
-
- 1 Proton
- 2 Electron
- 3 Neutron
45SUBATOMIC CHART
- Neutrons Protons
Electrons - Mass 1 1
0 - Charge 0 1
-1 - Symbol nº p
e-
46SUBATOMIC MASS CHARGE
- Subatomic mass is measured in a unit called amu
- amu stands for atomic mass unit
- 1 amu the mass of 1 p
- 1 amu 1/1,660,600,000,000,000,000,000,000 gram
- Roughly 1.7 septillionth of a paper clips mass!
- The 1 charge of the p and the 1 charge of the
e- - are relative charges. Theres no actual unit
(like volt) - Actual charges 1.67x10 -19 coulombs (C) for p
- -1.67x10 -19
coulombs for e-
47NUCLEUS
- Nucleus center of the atom
- Always has p
- Thus it always has an overall charge.
- Sometimes it contains neutrons (NO charge)
48ORBITALS
- A cloud or haze of orbiting e- around the
nucleus - AKA Energy levels, energy shells,
- e- levels, or e- shells
- Electrons ALWAYS orbit the nucleus
- Electrons are NEVER found inside the nucleus
49ALL ATOMS ARE ELECTRICALLY BALANCED (electrically
neutral)
- There is ALWAYS 1 e- for every p
- Thus
- p e-
- EX-
- 2 p 2 e- 0
(electrically neutral)
50ELEMENTS
- Defined as a pure substance of only 1 type of
atom - There are currently 114 known elements
- Make up the Periodic Table of the Elements
- They differ in their number of protons (p)
- ATOMIC NUMBER number of protons (p)
- Atomic p
51ATOMIC NUMBER
- Atomic p
- EX- Hydrogen has 1 p, Helium has 2 p
- Thus 1H and 2He
- H has the atomic 1, He has the atomic 2
52ELEMENTS IN THE HUMAN BODY
- There are about 20
- Most common are
- Element Atomic
- Carbon (C) 6
- Hydrogen (H) 1
- Oxygen (O) 8
- Nitrogen (N) 7
- Phosphorus (P) 15
53ATOMIC WEIGHT (or mass)
- Atomic weight (mass) refers to the weight (mass)
of the nucleus or the mass of all those p and
nº - Atomic weight p nº
- RECALL the nucleus is made of p and nº
- p and nº each weigh 1 amu (atomic mass unit)
- Adding a p adds BOTH 1 amu and 1 C to the
nucleus. - Adding a nº adds ONLY 1 amu. There is no extra
charge added (after all neutrons are neutral, O
C) - So.
54ATOMIC WEIGHT (or mass)
- Atomic weight p nº
- More p means more charge
- More nº just means it weighs more
- Neutrons are atomic fat!!
- They just add weight and nothing else.
55ELEMENTS IN THE HUMAN BODY
- There are about 20
- Most common are
- Element Atomic
Atomic Weight - Carbon (C) 6
12 - Hydrogen (H) 1
1 - Oxygen (O) 8
16 - Nitrogen (N) 7
14 - Phosphorus (P) 15
31 - Atomic weight p nº
56ATOMIC DATA
- How to quickly find
- p atomic number
- e- atomic number also
- RECALLall atoms are balanced so p e-
- nº atomic weight atomic number nº
- (p nº) -- p
nº - EX- (2 3) -- 2
3nº
57ISOTOPES
- Isotope An element that does not have the
typical - number of neutrons
- EX- Natural carbon is 12C.
- 11C, 13C, and 14C are isotopes (as in 14C
dating) - (sometimes less nº, sometimes more nº)
- Often unstable causing the nucleus to
disintegrate - This causes the emission of high energy particles
(like X rays) known as RADIATION.
58MOLECULES COMPOUNDS
- Molecule Group of atoms chemically joined
- Compound substance made of more than 1 kind of
element - EX- 2 oxygen atoms ?1 oxygen gas molecule
- (OO) ? (O2)
- 2 hydrogen atoms 1 oxygen atom ? H2O (water)
- Water is BOTH a molecule a compound.
593 KINDS OF CHEMICAL BONDS
- 1 Ionic steals e- (attraction of /-)
- 2 Covalent shares e-
- 3 Hydrogen polarity
60IONIC BONDS
- Steals e- to form IONS that attract each other
- ION atom with an overall /- charge
- Cation ions
- Anion -- ions
- EX- Na attracts Cl- to form NaCl.table salt
- NaCl is an example of an IONIC
compound
61COVALENT BONDS
- Covalent bonds form when atoms share e-
- EX- Carbon shares e- with 4 hydrogen atoms
- H
- This is
CH4 (methane) - H--- C ---H
-
- H
62HYDROGEN BONDING
- Weakest bond, occurs between POLAR molecules
- Polar molecules have 1 end and 1 end, sort of
like a bar magnet or a AA battery. - They can bond to themselves in chains.
- EX-
- -- --
--
63WATER IS POLAR!
- Water bonds to itself in chains
- H H H
H - O- O- O-
O- - H H H
H
64WHY IS WATER WET?(yes, there really is a reason
why!)
- Because it is both ADHESIVE COHESIVE!
- Cohesive it bonds to itself (in drops)
- Adhesive it bonds to other things (like glass)
- H H H
H - O- O- O-
O- - H H H
H
65Review the 3 Kinds of Chemical Bonds
- 1 Ionic- By gaining or losing e-, ions of
opposite charges are attracted to each other - 2 Covalent- atoms sharing e-
- 3 Hydrogen- weak bond between the oppositely
charged poles (ends) of polar molecules
66PREDICTING CHEMICAL BONDS
- Which chemicals will bond and which bond they
form is not by chance. - It depends on the of e- needed to complete the
outermost electron orbital. - VALENCE electrons the outermost electrons
- This is the basic idea of the Octet Rule
67THE OCTET RULE
- Oct- 8
- A) Inner orbitals MUST fill first
- B) 1st orbital holds 2 e- max
- C) 2nd orbital holds 8 e- max
- D) 3rd orbital holds 8 e- max
68WHAT DETERMINES IF AN ATOM IS BALANCED OR STABLE?
- By using the term ATOM, we mean it is BALANCED or
ELECTRICALLY NEUTRAL - BALANCED means the p e-
- All ()s plus all (-)s 0, they cancel each
other out - STABLE means the chemicals will not REACT
(will not try to form any type of bond). - STABLE they have a FULL VALENCE
69INERT GASES
- Inert not active, will not react
- Have a completed outer (valence) e- orbital is
stable - Last column on right in Periodic Table of
Elements - AKA Noble Gases
70INERT GASES (He)
- Helium (He) atomic 2
- 2 p and 2 e-
- 2 e- in inner orbital, He is chemically
non-reactive
71INERT GASES (Ne)
- Neon (Ne) atomic 10
- 2 e- in inner orbital, 8 e- in 2nd orbital
- Ne is chemically non-reactive
72IONS
- An ion is an atom (or group of atoms) that
carries an electric charge (/-) - Formed by too many or too little e-
- Cation ion
- Anion -- ion
- EX- Na, Cl- , NH4 , C2H3O2-
73SODIUM CATION
- Sodium atomic 11
- 11 p and 11 e-
- 2 e- in 1st orbital, 8 e- in 2nd orbital 1 e-
extra - The extra e- is lost (stolen), leaving the sodium
cation with a net positive chargeNa
74CHLORINE ANION
- Chlorine atomic 17
- 17 p and 17 e-
- 2 e- in 1st orbital, 8 e- in 2nd orbital, 7 e-
extra - 7 extra e- fill the 3rd orbital
- It needs 1 more e- to be chemically stable
- Chlorine anion attracts an extra e- to complete
its valence orbital ? has a net negative charge
(Cl-)
75OPPOSITES ATTRACT
- and charged ions attract each other
- Na joins Cl- to become NaCl (table salt)
- The molecule is both BALANCED STABLE.
- This is an IONIC BOND
- The bond comes from the mutual attraction of
oppositely charged ions - e- pass from 1 ion to another
- They are NOT shared, more like STOLEN!
76COVALENT BONDS
- When e- are shared between atoms
- HYDROGEN
- Hydrogen atomic 1
- 1p and 1 e-
- Needs 1 more e- to complete 1st orbital
77COVALENT BONDS
- CARBON
- Carbon atomic 6
- 6 p and 6 e-
- 6 e- is enough to fill the 1st orbital (2 e-)
with 4 e- left over for the 2nd orbital - It needs 4 more e- to complete it valence.
78COVALENT SINGLE BONDS
- When 1 e- is shared, shown by 1 line
- 1 carbon shares its valent e- with 4 hydrogens
- H
- This is
CH4 (methane) - H--- C ---H
-
- H
79COVALENT BONDS
- OXYGEN
- Oxygen atomic 8
- 8p and 8 e-
- Inner orbital filled with 2 e-
- 6 e- left over for 2nd orbital
- It needs 2 more e- to complete the 2nd orbital
80DOUBLE COVALENT BONDS
- When 2 pairs of electrons are shared
- Shown by 2 lines ()
- EX- OCOCO2.Carbon dioxide
- OO.O2Diatomic oxygen
- HONO.HNO3.Nitric acid
-
- H
- Diatomic 2 alike atoms bonded together (N2 ,O2,
H2)
81HYDROGEN BONDS
- Relatively weak bond between a positively charged
- hydrogen ion (H) in a molecule and a
negatively charged ion in another
molecule - EX- RECALL, polar water forms cohesive chains.
- HH
- O negative O end attracted by positive
H end - HH
- O
82POLAR MOLECULES
- Polar molecules molecules with an unequal
distribution of electrical charge (more e- on 1
end) - EX- water, isopropyl alcohol, hydrogen peroxide
83NONPOLAR MOLECULES
- Nonpolar molecules- molecules that have an equal
distribution of electrical charges (e-) - EX- gasoline, oil, wax, fatty acids
84RATING THE STRENGTHS OF CHEMICALS BONDS
- GOLD--------Covalent
- SILVER-------Ionic
- BRONZE-----Hydrogen
85REVIEW
- All matter is made of atoms
- Atoms consist of e-, p, nº
- Molecule group of atoms bound by covalent bonds
- H bonding occurs between polar molecules
- Ion atom with a charge
- Opposites charges may form ionic bonds
- Sec 2-1 Q1-5 pg 30
86WHAT IS pH?
- Water has 2 ions
- H plus OH- H2O
- H cation is a positive hydrogen ion
- OH- anion is called a hydroxide or hydroxyl group
- pH is a way of counting those H cations
87POTENZ H
- The H in pH stands for H (or hydrogen cation)
- The p in pH stands for potenz
- Potenz is the German term for
- the negative power of H
- When H increases, OH- decreases
- Its a fraction!
- H x OH- 10-14 or 1/100,000,000,000,000
88THE pH SCALE
- Think of pH as asking
- How many H are in a solution?
- The pH scale refers to H only
- The pH scale runs from 0-14
- lt7 acid, more H
- 7 neutral, like water because it has both H
OH- - gt7 base or alkaline, less H
89THE pH SCALE
- 0---------------------------7-----------------
-----------14 - Acid Base
- H, OH-
H, OH- - Neutral
- (H2O or HOH)
- H OH-
90THE pH SCALE
91The pH UNIT
- Each pH unit represents a factor of 10
- EX-
- The pH 6 is 100x more acidic than the pH 8
- (8-6 2102 100)
- Try thisItem A pH 9, Item B pH 5
- Which Item is more acidic and by how much?
92pH IN THE HUMAN BODY
- The body must maintain the pH of stuff within a
narrow range limits for the normal functioning of
physiological processes - Blood pH.7.2-7.4
- Saliva (spit) pH7
- Cytoplasm.7.2
- Stomach juices pH2
- Lysosome pH4-5
- Small intestine pH.8
- cells digestive enzyme sac--digests glucose
(1 human fuel)
93 WATER
- Covers 75 of the planet Earth
- Is molecularly 67 of the human body
- Polar ions dissolve well in it, after all
- Water is the UNIVERSAL SOLVENT, because most
things will dissolve in it. - Has a high heat of evaporation ? heat constancy
- Water is not lost easily body temp. remains
stable
94OTHER MOLECULES
- Other molecules are much, much bigger than water
- EX- proteins, carbohydrates, lipids, DNA
- These are ORGANIC molecules
- they all contain carbon (C)
- Sec 2-2 Q1-5 pg 33
95ORGANIC MOLECULES
- Always contain carbon (C)
- NO C, NO LIFE! All life on Earth is C based
- Cs 4 bonding sites allow life to be possible.
- Life on other planets SHOULD also be C based.
- If not, they may be silicon (Si) based as it too
has 4 bonding sites. - Note the location of C and Si on the Periodic
Table.
96ORGANIC MOLECULES
- Always contain carbon (C )
- Usually also contain hydrogen (H), oxygen (O),
/or nitrogen (N) - C and others are usually in long covalent chains
- EX- carbohydrates, proteins, lipids, enzymes,
- nucleic acids
97CARBOHYDRATES
- Ratio of CHO 121
- EX- C1H2O1 or C3H6O3
- Often abbreviated as CHO
- May exist as single molecules or in complex
chains
98MONOSACCHARIDES
- Simple sugars
- Mono 1, saccharide sugar
- Sugar names end in ose
- Glucose- C6H12O6---the basic plant sugar
- Fructose- in fruits like pears, pineapples
- Galactose- in plants and milk
99MONOSACCHARIDES
100DISACCHARIDES
- Are double sugars
- Di- means 2
- Monosaccharides monosaccharides disaccharide
- Sucrose some fruits
- Lactose in milk
- Maltose in (malt) chocolate
101DISACCHARIDES
102POLYSACCHARIDES
- Polysaccharides are CHOs that exist as long
chains of monosaccharides. - Poly- many
- EX- Starch- in potatoes
- Glycogen-stored body energy (not exactly fat
close) - Cellulose- pulpy stuff from plants makes paper
- Chitin (KI ten)- hard fiber found in animal
shells, insect exoskeletons (shells) in the
cell walls of fungi (mold mildew)
103POLYSACCHARIDES
104CHO COMPLEXITY
- CHOs are divided into 2 groups
- Simple CHOs Complex CHOs
- Simple CHOs include both monosaccharides and
- disaccharides
- Complex CHOs include polysaccharides
105SIMPLE CHOs
- Covalent bonds hold ALL monosaccharides together
- Glucose is the most important simple CHO!
- Glucose (C6H12O6) is the primary fuel for humans!
- (its the only fuel source used by the brain!)
- Glucose is made by plants during photosynthesis
- Glucose is made of 6 C molecules that form a ring
when they are dissolved in water. -
106EXAMPLES OF SIMPLE CHOs
- Mono- Mono- Di-
- glucose fructose SUCROSE
- glucose glucose MALTOSE
- glucose galactose LACTOSE
107COMPLEX CHOs
- These are polysaccharides long chains of
monosaccharides joined by covalent bonds - They serve as stored energy in plants (starch)
- animals (glycogen)
- Humans store glycogen in the liver muscles
- May be converted back into glucose when energy is
needed
108COMPLEX CHOs
- Some polysaccharides are rigid structural
materials - EX- Cellulose in plants, Chitin in arthropod
shells - Mammals cannot free glucose from cellulose alone
- We need help from bacteria in the post-stomach
digestive tract to break down cellulose fibers - Cellulose fibers are what we call roughage
- It is truly rough to digestlike the strings in
celery
109REVIEW
- pH scale 0-14, 0 acid (H), 14 base (OH-)
- 7 neutral (H2O or HOH) has both H OH-
- No C, No water, NO LIFE!
- C,H,O,N make organic molecules long chains
- Mono-, disaccharides are simple CHOs
- Polysaccharides are complex CHOs
- CHOs give people energy
- Glucose is the primary human fuel
110LIPIDS
- Type of fat
- These are non-polar molecules
- Nonpolarequal distribution of electrical charge
(e-)
111NONPOLAR REPELS WATER
- Nonpolar molecules never dissolve in water
- EX- water will not dissolve oil, gas, or wax
- Hydrophobic-(fears water) wont dissolve in H2O
- Hydrophilic- (loves water) easily dissolves in
H2O
112LAW OF POLARITY
- Like dissolves in like
- Polar dissolves in polar ONLY
- Nonpolar dissolves in nonpolar ONLY
- Water and oil dont mix!
1133 TYPES OF LIPIDS ESSENTIAL TO HUMANS
- 1 Triglycerides
- 2 Phospholipids
- 3 Steroids
114TRIGLYCERIDES
- Made of a Glycerol head and 3 Fatty Acid tails
- May be saturated or unsaturated
115SATURATED FATTY ACIDS
- The saturated fatty acid tails are C chains
crammed full or saturated with hydrogen atoms . - Saturated fats (EX-butter) are solid at room
temp. - Too much is VERY unhealthy!
116UNSATURATED FATTY ACIDS
- A double covalent bond exists between at least 1
pair of Cs (where Hs could bond with the C) - CC
- Unsaturated fats (EX-olive oil) -liquid at room
temp. - MUCH healthier (hydrogenated vegetable oil)
117POLYUNSATURATED FATTY ACIDS
- Unsaturated fats with fatty acid chains
containing more than 1 double covalent bond - Poly- manyEX- CCCC
- Healthiest of all!
118PHOSPHOLIPIDS
- Glycerol head,2 fatty acids phosphate group
(PO4) - Glycerol fatty acids are nonpolar (hydrophobic)
- Phosphate groups are polar (hydrophilic)
- A cell membrane (cells skin) is made of a double
layer of phospholipids phospholipid bilayer
119STEROIDS
- 4 C rings a functional group ( R)
- Many different kinds
- Important in reproductive maturation metabolism
- EX- Estrogen, testosterone, cholesterol
- NO FAT, NO SEX!
120PROTEINS
- PROTEINS chains of AMINO ACIDS (AA)
- Proteins are the building blocks of most body
structures (hair, cells, muscle, bone) - Most common organic molecule..its even in comets
- Found in ALL life.
121AMINO ACIDS
- Chainlike molecules with a central C bonded to
- 1 Amino group (NH2)
- 2 Carboxyl group (COOH)
- 3 a single hydrogen atom (H)
- 4 Side functional group (R )
122THE AMINO ALPHABET
- There are 20 amino acids important to biology
- There are 26 letters in the English alphabet
- Like how the order and amount of letters used
determine which word made, so the order and
amount of AA used determine which protein is
made. - What words are made from T,C,A?
123NUCLEIC ACIDS
- Nucleic acids Long chains of smaller
molecules called NUCLEOTIDES - Nucleotides have 3 parts
- 1 sugar (-ose)
- 2 base (OH-, the opposite of an acid)
- 3 phosphate group (PO4)
1242 TYPES OF NUCLEIC ACIDS
- 1 DNA (deoxyribonucleic acid)
- 2 RNA (ribonucleic acid)
125DNA
- DNA has 2 strands of nucleotides that spiral
around each other. - This is called a double helix
- Shape was discovered by Watson Crick in 1953
- The strands are held together by H bonds between
bases across from each other forming the
rungs of the twisted ladder.
126CHROMOSOMES ARE DNA
- Chromosomes are made up of very long strands of
DNA, which is the code on genes containing the
instructions for making proteins
127RNA
- Single strand of nucleotides
- Plays several roles in cells, esp. in making
protein
128ATP
- ATP a nucleotide called adenosine triphosphate
- Its a single nucleotide with 2 extra, high
- energy-storing phosphate (PO4) groups
- It stores energy ONLY TEMPORARILY, like a
battery, between the 2nd 3rd PO4s. - A-PO4-PO4 PO4
- When we catabolize food, energy is released.
- Energy is captured stored in ATP,
later used to operate the bodys
individual cells.
129REVIEW
- Organic componds (C) are found in living things.
- CHOs, like glucose, are energy sources some are
used as structural materials in organisms. - Lipids are nonpolar molecules that store energy
found in cell membranes as phosphlipids. - Proteins are chains of AA, The AA sequence
determines a proteins shape function. - Nucleic acids store transmit heredity info.
- ATP is the main energy currency of cells
- Sec 2-3 Q 1-5 pg 37
130WHAT GOOD ARE PROTEINS?
131CYTOLOGY
- Cyte- cell
- -ology study of
- CYTOLOGY study of cells
132FOUNDERS OF CYTOLOGY
- Robert Hooke
- Anton van Leeuwenhoek
- Mattias Schleiden
- Theodor Schwann
- Rudolph Virchow
133ROBERT HOOKE
- In 1665 observed slices of cork under a
microscope - He saw little boxes
- He named these boxes cells, because they
reminded him of the small rooms where monks
lived inside monastaries.
134ANTON van LEEUWENHOEK
- Used a microscope to observe drops of rain water
- He discovered little creatures living there!
- He named these creatures animalcules, which
means tiny animals.
135INTERNATIONAL SYSTEM OF MEASUREMENTS
- Abbreviated SI
- Same thing as the metric system
- It is a decimal system
- All units are based upon powers of 10
- WHY?
136BRIEF SI TABLE
- Meter base unit for measuring distance
- Meter literally means measure________________
- kilo- 1,000
- -meter 1
- centi- .01 or 1/100
- milli- .001 or 1/1000
- micro- .000001 or 1/1,000,000 (1 millionth)
- nano- .000000001 or 1/1,000,000,000 (1
billionth)
137SI SYMBOLS
- km kilometer
- meter 3.???ft
- cm centimeter
- mm millimeter
- µm micrometer
- nm nanometer
138CHARACTERISTICS OF MICROSCOPES
- Two Types of Microscopes
- 1 Light microscopes
- 2 Electron microscopes
139LIGHT MICROSCOPES
- Light passes through one or more lenses to
produce an enlarged image of a specimen or
MICROGRAPH - MICROGRAPH an image produced by a microscope
140MAGNIFICATION
- Ability to make an image appear larger than its
actual size - EX- Magnification value of 200x means the image
is 200 times larger than the actual specimen
141RESOLUTION
- A measure of the clarity of an image
- RECALLAs magnification increases,
- resolution decreases!
- The bigger the image, the blurrier it
gets!
142ELECTRON MICROSCOPES
- Forms an image of a specimen using a beam of
electrons instead of light - No cell can survive an e- microscope as specimen
preparation requires a type of staining being
placed in a vacuum (/or being sliced!) - TWO TYPES
- 1 TEM transmission e- microscope
- 2 SEM scanning e- microscope
143TEM
- Transmission e- microscope
- The e- beam is aimed at a slice of a specimen
stained with metal ions - TEM micrographs are always black white
144SEM
- Scanning e- microscope
- The e- beam is aimed at a specimen coated with
metal ions - SEM micrographs are 3D, usually BW, but can be
artificially colored
145STM
- Scanning Tunneling Microscope
- Uses a needle-like probe to measure differences
in voltage caused by e- s that leak,or tunnel,
- from the surface of a specimen
- A computer tracks the movement of the probe
- STM micrographs are 3D and in color
- STMs can be used to study living specimens
- You can even see individual atoms!
146MICROSCOPE REVIEW
- Microscopes enable us to examine the details of
cell structure to understand how organisms
function. - Scientists use the SI system to measure the size
of objects - Light microscopes have a low magnification can
be used to examine living cells. - Electron microscopes have a high magnification,
but cannot be used to study living cells - The STM uses a computer to generate 3D images of
a specimen. - Sec 3-1 Q1-5 pg 54
147CELL THEORISTS
- Mattias Schleiden--
- German botanist in 1838 concluded that a plant
was composed entirely of cells - Theodor Schwann--
- German zoologist who claimed that animals were
also made up of cells - Rudolph Virchow--
- German physician who determined that cells come
only from other cells
148CELL THEORY
- Based on the combined observations of
- Schleiden, Schwann, Virchow
- All living things are made of one or more cells
- Cells are the basic unit of structure function
- All cells arise from pre-existing cells
149CELLS MUST BE SMALL
- Small cells work more efficiently than large
cells - All substances that enter or leave a cell must
cross the cells surface - If the cells surface-to-area ratio is too low,
substances cannot move through the cell quickly
enough to meet the cells needs. - Substances do not need to travel as far to reach
the center of a smaller cell. - This is why smaller things are more efficient
(ants).
150CELL FEATURES
- There are many parts needed to make up a
functioning cell. - These parts are referred to as cellular
features or organelles (meaning little
organs)
151CELL MEMBRANE
- Outer boundary, skin
- Encloses the cell separates its interior from
its outer surroundings - Regulates what enters leaves the cell
152CYTOPLASM
- Is the interior of a cell
- It is mostly water, so it is very fluid
153CYTOSKELETON
- A collection of connected microscopic protein
fibers that suspends other cell structures within
the cytoplasm - Like the metal skeleton of a skyscraper,
- only much smaller.
- The cytoskeleton holds the cell together keeps
it from collapsing
154RIBOSOMES
- Cellular structures that make protein
- These are the Protein Factories!
155DNA
- Deoxyribonucleic acid
- Provides the instructions for making protein that
will be read by the ribosomes. - These instructions regulate cell activity and
provide a raw building material for making what
the cell needs. - It also enables the cell to reproduce by storing
hereditary information.
156TWO TYPES OF CELLS
- 1 Prokaryotes
- 2 Eukaryotes
157PROKARYOTES
- Simplest smallest cells
- Lack a nucleus other internal compartments
known as organelles. - Cannot carry out specialized functions
- Genetic material is a single circular strand of
DNA - Modern prokaryotes are called BACTERIA
158BACTERIA
- Modern prokaryotes
- Exist in a broad range of conditions
- Grow divide rapidly
- Some can make their own food
- Some can live without oxygen
- Enzymes ribosomes are free to move around in
the cytoplasm because there are no internal
structures (organelles) to divide the cell into
compartments their parts float around in
there! - DNA is circular (ring), suspended in the cytoplasm
159CELL WALL
- Surrounds the cell membrane to provide
- protection, structure, support.
- Think of the cell membrane as the SKIN,
- The cell wall as the SUIT OF ARMOR.
- Cell walls are found in bacteria, fungi,
plants.
160CAPSULE
- Strands of polysaccharides that may surround the
cell wall of a bacteria - These enable the bacteria to cling to almost
anything - The capsule is like a Velcro suit!
161FLAGELLA
- Single (only 1) called a flagellum
- More than one called flagella
- Long, threadlike structures that protrude from
the cells surface - Long, whip-like tails that allow some cells to
swim or move
162EUKARYOTES
- First cells with internal compartments
- Have a nucleus
- Have other organelles
163NUCLEUS
- Control center of the cell, like the brain
- Internal compartment (organelle) that
- houses the cells DNA
- It has all the info. (DNA), so it is the
- boss (control center)!
164ORGANELLE
- Any structure that carries out a specific
activity inside of a cell - It comes from the French language meaning
- little organs. (-elle little)
165CILIA
- Small hair-like structures, found on some
eukaryotes, that protrude from the cell membrane. - Used to make oar-like movements
- May be used to help a cell swim through a fluid
- May also be used to move substances across a
cells surface - EX- Cilia in the wind pipes sweep debris mucus
out of the lungs
166CYTOPLASM vs. PROTOPLASM
- Cytoplasm everything inside the cell membrane,
- BUT OUTSIDE the nucleus
- Protoplasm Everything inside the cell membrane,
including the nucleus - Protoplasm is ALLDAT, cytoplasm is not.
- EX- Cytoplasm Nucleus Protoplasm
167CYTOSKELETON FIBERS
- The eukaryotic cell is supported by the
cytoskeleton - There are 2 types of protein fibers that form the
cytoskeleton - 1 Microtubuleshollow, flexible
- 2 Microfilamentssolid, rigid
168MICROTUBULES
- 1 of the 2 types of protein fibers in the
cytoskeleton - Microtubules are long tubes (tubules)
- Long, hollow tubes that extend throughout
the cytoplasm - These, being hollow, are easy to bend and allow
the cell to flex and it may also help move
organelles around inside the cell
169MICROFILAMENTS
- 1 of the 2 types of protein fibers in the
cytoskeleton - These are thin protein strands that help support
the cells shape structure - They are solid, unlike microtubules.
- These give strength and rigidity to the
cytoskeleton - Microfilaments hold things in place, restricting
movement
170CELL STRUCTURE REVIEW
- Cell membrane Skin
- Cell wall Suit of Armor
- Capsule Velcro Suit
- Nucleus Brain
- Flagella long swimming tail, whip-like
- Cilia short swimming hairs, oar-like
- Cytoskeleton 2 protein fibers
- 1 microtubules (hollow), 2 microfilament (solid)
171CELL MEMBRANES
- Cell membranes are fluid like a soap bubble.
- The fluidity of the cell membrane is caused by
lipids - These lipids form a barrier that separates the
inside of a cell from the outer environment - The cell membrane is selectively permeable
- It allows only certain substances to enter and
exit - the cell
172PHOSPHOLIPIDS
- Interacts with water to cause a cell membrane to
become selectively permeable - Made of a phosphate group (PO4) with 2 fatty
acids - Has a polar head and 2 nonpolar tails
- The head contains the phosphate group is
attracted to water (hydrophilic loves water) - The tails contain the nonpolar fatty acids
- repels water (hydrophobic fears water)
173LIPID BILAYER
- Phospholipids arranged in double layers (2 ply)
- This arrangement is found in the cell membrane
- Nonpolar tails of the phospholipids make up the
interior of the bilayer they are forced to
remain here because water inside outside the
cell repels them. - Ions polar molecules, including proteins
sugars, are repelled by the nonpolar interior of
the bilayer, forcing them to remain outside the
cell. - It takes an active door to let them inside the
cell.
174PROTEINS EMBEDDED IN THE LIPID BILAYER
- Proteins are chains of amino acids, some of which
are polar, others nonpolar. - The nonpolar parts (center) of a protein is
attracted to the interior of the lipid bilayer,
but is repelled by the water inside outside the
cell. - The polar parts (ends) of the protein are
attracted to the water on both sides of the lipid
bilayer. - These attractions hold the protein in the proper
position inside the lipid bilayer (cell
membrane).
175TYPES OF CELL MEMBRANE PROTEINS
- 1 Cell-surface marker proteins attached to a CHO
help define cell type (like a name tagliver,
heart, blood, etc.) - 2 Receptor proteins recognize join with
specific substances. - 3 Enzymes embedded in the cell membrane are
involved in biochemical reactions inside the
cell. - 4 Transport proteins aid in the movement of
substances into out of the cell.
176TYPES OF CELL MEMBRANE PROTEINS REVIEW
- 1 Cell-surface marker proteins name tags
- 2 Receptor proteins antennae for
hormones/signals - 3 Enzymes speed up biochemical reactions
- 4 Transport proteins doorways
- REMEMBER
- The cell membrane is fluid due to the lipids,
allowing the proteins to move or float round - Imagine a wall with a floating door! They
actually exist!
177REVIEW
- The cell theory has 3 parts.
- Small cells function more efficiently than large
ones because small cells have a higher
surface-area-to- volume ratio than larger cells. - All cells have a cell membrane, cytoplasm,
ribosomes, DNA . - Prokaryotic cells NO nucleus, NO organelles
- Eukaryotic cells HAVE nucleus, organelles,
cytoskeleton - The lipid bilayer of a cell membrane is made of a
double layer of phospholipid molecules. - Proteins in cell membranes include enzymes,
receptor proteins, transport proteins,
cell-surface marker proteins - Sec 3-2 Q1-5 pg 60
178ORGANELLES (pgs 55-66)
- Little organs inside a cell,
- much like our own organs.
- These are the separate compartments inside a cell
that perform specialized functions. - Organelles are suspended in CYTOSOL (fluid)
- Organelles Cytosol Cytoplasm (solids fluid)
- Organelles are ONLY found in eukaryotes.
- (NOT in prokaryotes bacteria)
179EXAMPLES OF ORGANELLES
- 1 Nucleus
- 2 Nucleolus
- 3 Ribosomes
- 4 Endoplasmic reticulum (ER) rER sER
- 5 Golgi apparatus
- 6 Cell membrane ( cell wall if present)
- 7 Mitochondria
- 8 Lysosomes
- 9 Peroxisomes
- 10 Centrioles
180NUCLEUS
- Control center of a cell, brain
- Surrounded by a double membrane called the
nuclear envelope or nuclear membrane. - Ribosomal proteins RNA are made here
- Ribosomes are partially formed in a central area
of the nucleus called the NUCLEOLUS.
181NUCLEAR DNA
- Most of the cells DNA is stored in the nucleus.
- Nuclear DNA stores genetic information.
- It also contains the instructions for the proper
amino acid sequence of each protein. - Proteins regulate chemical reactions many other
cellular functions - THUS
- The nucleus is the control center because it
regulates cell structure function by
controlling protein production.
182DNA CHROMOSOMES
- Most of the cells DNA is stored in the nucleus
- DNA exists most of the time in the form of
elongated strands or strings. - When a cell is about to divide, DNA strands wind
into a compact rod shaped form called
Chromosomes. - These are not visible unless cell ready to
divide. - DNA is the yarn, Chromosomes are the skeen,
Genes are the designs/ stripes in the skeen.
183NUCLEOLUS
- Very center of the nucleus
- Completely enclosed by the nucleus
- Houses RNA
184NUCLEAR ENVELOPE
- Sometimes called the nuclear membrane
- It completely encloses the nucleus, skin
- Made of 2 lipid bilayers that separate the
nucleus from the cytoplasm - Small channels called nuclear pores cover its
surface - These pores allow RNA to move out of the nucleus
into the cytoplasm of the cell.
185RIBOSOMES
- They make protein! HOW?
- 1 The genetic code of DNA is translated into
mesenger RNA (mRNA) in the nucleus. - 2 mRNA leaves the nucleus through nuclear pores
in the nuclear envelope, heads to the ribosomes. - 3 Ribosomes chemically read the translated code
on the mRNA strands link amino acids together
in the correct sequence to make a protein. The
mRNA holds a translation of DNAs instructions on
which order to place the amino acids in to make a
specific protein.
186ENDOPLASMIC RETICULUM (ER)
- Endo- inside, -plasmic cytoplasm
- Reticulum network or system
- ER a network inside the cytoplasm of a cell
- The ER is a system of internal membranes that
move proteins other substances throughout the
cell. - The membranes are made up of a lipid bilayer with
embedded proteins. - Its usually directly attached to the inside of
the - cell membrane.
- ER is divided into the rough ER the smooth ER.
187ROUGH ER (rER)
- This is the part of the ER that houses ribosomes.
- RECALLRibosomes make protein
- The rER helps transport the proteins made by the
attached ribosomes, like a railroad next to a
factory. - As a protein is made, it passes through the ER
membrane into the hollow of the ER tube. - The completed protein becomes surrounded as a
piece of the ER wall is pinched off to form a
Vesicle - (fatty sac) around the new protein like a
package.
188VESICLES
- Vesicles are a small membrane sac that transports
substances in a cell. - They are usually made from the pinched off walls
of an organelle or a lipid bilayer. - EX-Vesicles can be made from the walls of the ER,
- Golgi apparatus, cell membrane.
189SMOOTH ER (sER)
- Part of the ER that lacks ribosomes
- (that is why its smooth!).
- Its downstream from the rough ER (rER).
- It simply exists as a tube through which vesicles
(containing proteins and other substances)
travel. - The sER makes phospholipids to maintain patch
the cell membrane. - It also detoxifies toxins like alcoholliver
cells contain many lengths of sER.
190GOLGI APPARATUS
- Named after ________ Golgi
- Set of flattened, membrane-bound sacs that serve
to package distribute proteins. - Enzymes in the Golgi apparatus modify the
proteins. - Modified proteins are repackaged into new
vesicles that form from the pinched-off lipid
surface of the Golgi apparatus.
191CELL MEMBRANE
- Acts as a skin to protect hold the cell
together. - However, vesicles can flow through the cell
membrane easily as to export its contents
outside the cell. - When vesicles empty their contents outside the
cell, the process is called EXOCYTOSIS, meaning
to exit the cell.
192THE MIGHTY MITOCHONDRIA
- Mitochondrion if singular, (2 Mitochondria)
- This is the organelle that harvests energy from
organic compounds to make ATP, the main energy
currency of cells - This is the Powerhouse of the Cell.
- Cells with a high energy requirement, like muscle
cells, may contain thousands of mitochondria.
193MITOCHONDRIAL STRUCTURE
- It has both an inner an outer membrane
- The outer is smooth, the inner is folded to
increase the surface area for chemical
reactions. - Chemical reactions occur in both membranes to
produce ATP, but mostly on the folded inner
membrane because there is more room. - Mito pic! needed
194MITOCHONDRIAL FUNCTION
- These are the sites of energy production.
- C6H12O6 6O2 ? 6CO2 6H2O
E - glucose oxygen carbon dioxide water
energy - This chemical equation makes life on Earth
possible. - Cellular respiration is photosynthesis in reverse!
195WHAT HAPPENS TO THE ENERGY?
- Adenosine triphosphate (ATP) is the energy saver
of the cell. - ATP works like a battery to temporarily store
energy - High energy bonds exist between the last 2 PO4 s
- A-PO4-PO4 PO4
- EACH molecule of glucose charges 38 ATPs !!!
196ATP
- Adenosine triphosphate, a nucleotide
- It is the main energy currency of cells.
- Some ATP is produced in the cytoplasm,
- but the majority is produced by mitochondria.
- The ATPs circulates throughout the body
dispersing energy needed for skeletal muscles
the heart, as well as the energy needed to start
chemical reactions for life, memories, dreams,
to name a few uses. - Anywhere energy is needed, ATP supplies.
197MITOCHONDRIAL DNA
- Mitochondria also have their own DNA, ribosomes,
produce some of their own proteins! - Mitochondrial DNA is independent of nuclear DNA
is similar to the circular DNA of bacteria. - The widely accepted Endosymbiotic Theory, states
that prokaryotes may be the ancestors of animal
mitochondria, that at 1 time they were free
living organisms that formed a mutual
relationship with another cell!
198ENDOSYMBIOTIC THEORY?
199LYSOSOMES
- Small vesicles (also considered organelles) that
contain a cells digestive enzymes. - This is one type of vesicle that contains a
protein (enzyme) formed by the Golgi apparatus
that stays inside the cell for its function it
does not leave the cell by the process or
exocytosis. - The PEROXISOME is another example of a vesicle
that remains inside the cell.
200LYSOSOME FUNCTIONS
- They often migrate to mitochondria to digest
glucose to release energy used to charge ATP. - Others are used to eat bacteria, germs, invaders.
- Also used to recycle wornout/defective
- organelles cells.
- Lots of them are inside WBCs (white blood cells)
- for immunity (eating germs).
201PEROXISOMES
- Enzyme-filled vesicles that digest fats.
- RECALL...fats long chains of nonpolar fatty
acids - Peroxisomes are also made by the Golgi apparatus
stay inside the cell, like lysosomes. - They are involved in removing poiso