Gene Chasing with the Hierarchical Clustering Explorer: Finding Meaningful Clusters in High Dimensional Data

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Gene Chasing with the Hierarchical Clustering
Explorer Finding Meaningful Clusters in High
Dimensional Data

• Jinwook Seo and Ben Shneiderman
• HCIL

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Understanding Clusters

• Cluster Identification
• How to identify interesting clusters
• Interactive exploration of clustering results
• Understanding Clusters
• Experts domain knowledge
• Intuitive search mechanisms
• Overlap of clusters and search results

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Mouse Muscle Regeneration
Time 0 12Hr 1Day 2Day
. 30Day 40Day
Measure the activities of 12,422 genes at 27
time points
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Clustering Result Overview
Genes
Time
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Searching for Clusters
Minimum Similarity Bar
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Searching for Clusters
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Searching for Clusters
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Searching for Clusters
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Hierarchical Clustering Explorer

• 1400 downloads since April 2002
• www.cs.umd.edu/hcil/hce
• 1 commercial license to a biotech company
• Demonstration at HCIL1
• Try HCE to analyze your multidimensional data
• 3138 US Counties
• Demographic data

Sponsored by Childrens National Medical
Center
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Thank you !