PSY 335A Drugs and Behavior

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PSY 335A Drugs and Behavior

• Introductory Class

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Drugs and Behavior

• Course overview Web site and syllabus
• Discussion and questions
• Drugs and behavior in the disciplines
• Classification schemes
• Juliens classification scheme

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Drugs and Behavior in the Disciplines

• DB is at the interface of medical science and
  psychology
• Pharmacology and Behavioral Medicine
• Psychopharmacology
• Neuropsychopharmacology, neuropharmacology, and
  drugs and behavior
• Contributing disciplines

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Classification Schemes

• Dichotomous classification schemes
• Prescription vs. OTC
• Therapeutic vs. recreational
• Licit vs. illicit
• Uppers vs. downers
• Financially viable vs. non-viable

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More classification schemes

• By mechanism of action
• By chemical structure
• By single effect
• EEG-shift (Fink, 1968)
• ANS effect Parasympathomimetic vs.
  sympathomimetic
• By main effect Juliens scheme

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Juliens classification schemes

• 1978 Five categories
• Sedatives and hypnotics
• Stimulants and convulsants
• Narcotic analgesics
• Antipsychotic agents
• Psychedelics and hallucinogens
• 1998 Nine categories

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Juliens 1998 classification

• I. Nonselective CNS depressants
• II. Antianxiety agents
• III. Antiepileptic drugs
• IV. Psychostimulants
• V. Antidepressants
• VI. Mood stabilizers
• VII. Opioid analgesics

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Julien (1998) continued...

• VIII. Antipsychotic agents
• IX. Psychedelics and hallucinogens
• Julien also discusses other drugs which do not
  fit into his classification scheme
• Non-opioid analgesics
• Antiparkinsonian drugs
• Fertility-regulating drugs
• Anabolic-androgenic steroids

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Basic Terminology of Drug Action

• Chemical name vs. generic name vs. Trade Name v.
  street name
• Mithradatism

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Tolerance

• Tolerance phenomena
• Tachyphylaxis and acute tolerance
• Metabolic tolerance, physiological tolerance, and
  behavioral tolerance
• Mixed tolerance
• Cross tolerance
• Reverse tolerance or sensitization

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Dependence and Addiction

• Physiological dependence The abstinence syndrome
• Habituation and conditioning
• Addiction and behavioral reinforcement
• Positive reinforcement
• Negative reinforcement

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Polydrug UseInteractions

• Agonist effects
• Antagonist effects
• Synergistic effects

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