Sunil V Rao MD Assistant Professor of Medicine Duke University Medical Center The Duke Clinical Rese

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Sunil V Rao MDAssistant Professor of
MedicineDuke University Medical CenterThe Duke
Clinical Research InstituteDurham VA Medical
CenterDurham, NC
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Clopidogrel loading

• 190 patients undergoing elective coronary
  stenting
• Clopidogrel given immediately post-procedure
• Non-responsiveness defined as ? platelet
  aggregation lt10 (baseline post procedure)

Gurbel PA, et al. JACC 2005
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ARMYDA-2
Patti G, et al. Circulation 2005
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ARMYDA-2 30-day Death/MI/TVR

• Patients
• 25 NSTE-ACS
• Other antiplatelet Rx
• 13 GP IIb/IIa inhibitor use
• Stents
• 99 stent use
• 20 DES
• Median time between load and PCI 6 hrs

Patti G, et al. Circulation 2005
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ARMYDA-2 Periprocedural marker release
Patti G, et al. Circulation 2005
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ARMYDA-2 Predictors of periprocedural MI
Patti G, et al. Circulation 2005