C'A'T'E' Computer Aided Tissue Engineering

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C.A.T.E.Computer Aided Tissue Engineering

• Presentation by David Biando, M.S.
• R.E.T. Fellow

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C.A.T.E.Computer Aided Tissue Engineering

• Contents
• CATE
• Objective
• Definitions
• Goals
• Obstacles
• Biandos Research Project Hypotheses
• Modular Scaffold and Interconnectivity
• Fibonacci Sequence
• Procedures
• Classroom Lessons
• Introduction to Engineering and other
  Interdisciplinary Fields like Bioengineering.
• Introduction to CAD modeling software.

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• Objectives The intention of this presentation is
  essentially meant to serve three purposes
• Introduce CATE to you.
• Inform you of my research.
• Share some insight with you.

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• B. Definitions Tissue Engineering is an
  interdisciplinary field consisting of engineers
  working with biologists and medical scientists
  searching to replace or improve the function of
  tissues and organs, which have lost function due
  to trauma, illness, aging or congenital diseases,
  through the application of biomaterials and
  procedures that work with the natural rebuilding
  processes and technology.

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• C. Goals
• Challenges of Interdisciplinary Fields
• BioMedical Life scientists, biochemists, and
  geneticists are going to play a large part in the
  overall success of tissue engineering. We need to
  better understand the basis of life at the
  sub-molecular level in order to be successful.
  Understanding all the necessary requirements,
  environments, chemistry, and mechanisms of a cell
  is essential for all parties involved in tissue
  engineering. This may be one of our biggest
  challenges in tissue engineering.
• Focuses Stem cell research, DNA sequence decoding

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• C. Goals
• Challenges of Interdisciplinary Fields
• BioTechnology In order to be successful
  engineers will need to improve and develop new
  technological tools specifically for the purpose
  of tissue engineering. Computer aided design
  (CAD) software programs will need to be able to
  handle complex algorithms to model and predict
  the behavior of cells under different conditions
  and work on heterogeneous structures.
• Focuses (BioCAD)

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• C. Goals
• Challenges of Interdisciplinary Fields
• BioTechnology Non-invasive imaging systems need
  to be developed in order to obtain increased
  information about the processes and behavior of
  tissue regeneration in vivo.
• Focuses Improved CT/MRI Imaging (mCT/mMRI),
  endoscopic or development SLS (see through)
  scaffold materials, nano-probes.

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• C. Goals
• Challenges of Interdisciplinary Fields
• BioEngineering Development of tissue scaffolds
  and development of fabrication and manufacturing
  processes.
• Focuses Accurate biomimetic modeling, Boolean
  operations, improved computer-aided tissue
  informatics, SFF technology, smart scaffold
  design, improved 3D cell and organ printing and
  scaffold fabrication devices.

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• D. Obstacles
• Challenges to Tissue Engineering
• Biological Issues
• DNA Decoding

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• D. Obstacles
• Challenges to Tissue Engineering
• Biological Issues
• DNA Decoding
• Cell Growth Control

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• D. Obstacles
• Challenges to Tissue Engineering
• Biological Issues
• DNA Decoding
• Cell Growth Control
• Immune Rejection

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• D. Obstacles
• Challenges to Tissue Engineering
• Biological Issues
• DNA Decoding
• Cell Growth Control
• Immune Rejection
• Vascularization

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• D. Obstacles
• Challenges to Tissue Engineering
• Technological Issues To support and guide the
  development and growth of cells into desired
  tissues, scaffolds have to be designed that
  provide the right environment for cell
  attachment, cell growth and vascularization to
  take place.
• Biological unknowns (as stated previously)
• Cart before the horse
• Non-invasive imaging systems need to be developed
• Inadequate CAD capabilities

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• D. Obstacles
• Challenges to Tissue Engineering
• Technological Issues To support and guide the
  development and growth of cells into desired
  tissues, scaffolds have to be designed that
  provide the right environment for cell
  attachment, cell growth and vascularization to
  take place.
• Biological unknowns (as stated previously)
• Cart before the horse
• Non-invasive imaging systems need to be developed
• Inadequate CAD capabilities

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C.A.T.E.Computer Aided Tissue Engineering

• CATE
• D. Obstacles
• Challenges to Tissue Engineering
• 3. Ethical Issues
• Political Climates
• Religious Foundations
• Fear of the Unknown
• Frankenstein Syndrome

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C.A.T.E.Computer Aided Tissue Engineering

• II. Biandos Research Project Hypotheses
• Modular Scaffold and Interconnectivity
• Developing a tissue scaffold that is modular in
  design and connects to other similar scaffolds by
  a interlinking system will allow for easy access
  and observation which will increase bioinfomatics
  with regards to cell livelihood, migration and
  behavior while in an invitro state.

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C.A.T.E.Computer Aided Tissue Engineering

• II. Biandos Research Project Hypotheses
• Modular Scaffold and Interconnectivity
• Fibonacci Sequence
• Designing a tissue scaffold that employees
  Fibonacci Sequence would be a more accurate
  biomimetic model and would allow for better cell
  formation and migration.

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C.A.T.E.Computer Aided Tissue Engineering

• II. Biandos Research Project Hypotheses
• C. Procedures
• 1. Learn more CAD programs
• 2. Continue to research hypotheses
• 3. Design scaffolds employing hypotheses
• 4. Test design types by introducing cells
  and measuring results.
• 5. Draw conclusions

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C.A.T.E.Computer Aided Tissue Engineering

• III. Classroom Lessons
• Introduction to Engineering and other
  Interdisciplinary Fields like Bioengineering.
• Introduction to CAD modeling software.