The 4 key sentences structure

1
Example
2
Example
3
The 4 key sentences structure

• First sentence of the introduction
• miniseminar
• Last sentence of the introduction
• What you actually did
• First sentence of the discussion
• What you found
• Last sentence of the discussion
• What it means

4

• First sentence of the introduction
• Last sentence of the introduction

5

• First sentence of the discussion

6

• Last sentence of the discussion

7
Official abstract

• Cholesterol biosynthesis is an integral part of
  HCV RNA replication. Not only does HCV RNA
  replicate on lipid rafts, but it also requires
  cholesterol intermediates to replicate. In
  addition, it has been shown in vitro that several
  HMG-CoA reductase inhibitors can decrease HCV RNA
  replication bygt1 log. Therefore, we designed a
  clinical trial to evaluate the effect of
  atorvastatin on HCV RNA levels. In this
  prospective clinical trial, where patients served
  as their own control, 10 HCV-infected patients
  who required treatment for high cholesterol were
  given 20 mg atorvastatin per day. Although serum
  cholesterol and LDL predictably decreased
  signi.cantly, there was no statistically
  signi.cant change in week 4 and week 12 HCV RNA
  levels compared to pretreatment HCV RNA levels by
  the paired Student t test. It is unclear whether
  the addition of an HMG-CoA reductase inhibitor to
  interferon or a more potent inhibitor of
  cholesterol biosynthesis may be required to
  inhibitHCVRNA replication in vivo. In conclusion,
  atorvastatin, and likely all HMG-CoA reductase
  inhibitors, does not inhibit HCV RNA replication
  in vivo at conventional doses. (HEPATOLOGY
  200745895-898.)

8
Example
1. purpose
9
Example
2. Results
10
Example
3. conclusion
11
Example
12
Example

• Although atorvastatin was effective at
  lowering cholesterol, it did not show a
  statistically significant change in HCV RNA level
  after 4 or 12 weeks of therapy
• ..We had 95 power.thus, if the effects had
  been as dramatic as seen in vitro, we would have
  detected a difference
• ..most plausible explanation is that the plasma
  concentrations of atorvastatin in our study were
  unlikely to reach those attained in culture media
  concentration.
• atorvastatin at conventional doses does not
  have an antiviral effect
• ..role of inhibitors of cholesterol and lipid
  metabolism as adjuncts to HCV therapy merits
  further evaluation