4, rue Pierre Fontaine

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4, rue Pierre Fontaine 91000 Evry France Tel 33
(0)1 60 87 89 00 Fax [phone]
99 www.obetherapy.com
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• Obesity Difference between
• Energy intake Energy expenditure
• (food)
  (metabolism physical activity)

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The pharmaceutical industry approach
Identify obesity genes Find molecules that
are able to modulate the function of these target
genes
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Problems with obesity genes

• They form a very complex network
• They are redundant and lack specificity
• Inhibition or activation of a single gene is
  compensated by other genes

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Obesity genes
Appetit
Satiety
Fat Absorption
PL (Orlistat)
MTP
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Every gene involved, directly and/or
indirectly in energy formation (ATP)
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Every gene involved, directly and/or
indirectly in energy formation (ATP)
is an obesity gene.
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Every gene involved, directly and/or
indirectly in energy formation (ATP)
is an obesity gene.
Probably several hundred genes.
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Our goal
To find efficient drugs against obesity,
lipidemia and type II diabetes through a
completely innovative approach.
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Our Goal Efficiency
- Our target is specific - Its function is not
redundant
- Efficiency - No side effect
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Slimness gene as new target for the treatment
of obesity, lipidemia and type II diabetes
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Our strategy
Is there any genetic disease in which the
phenotype is lean, low cholesterol and low
triglycerides ?
A single gene with a tissue specific expression
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From a particular case (slim phenotype)
To treat general obesity cases
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Advantages of our anti-obesity target versus
competitor targets
Specificity - Specific function - Tissue
specific expression (intestine) Non Redundant
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Current Situation
A first therapeutic target validated Patent
pending A list of potential hit compounds
 obtained by virtual screening Patent pending
A patented HTS assay design for our first target
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Next steps
Enhance the value of the company and reduce the
risks to investors in order to attract Venture
Capital
In-vitro and cellular testing hit compounds
In-vivo testing for best leads Clinical Study
phase I first Q1 2004 HTS for new hit
compounds Transgenic rabbits dominant/negative
and/or RNAi Polymorphism of other candidat
genes
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Slimness genes allow you to eat without gaining
weight.
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Slimness genes allow you to eat without gaining
weight.
Nature did it,
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Slimness genes allow you to eat without gaining
weight.
Nature did it,