Title: Productivity, Access, and Risk: the Keys to Biotechnology in Developing Countries
1Productivity, Access, and Risk the Keys to
Biotechnology in Developing Countries
- David Zilberman, University of California
- EEP101/econ125
2What is biotechnology?
- Biotechnology is applying tools of molecular and
cell biology to problems of health, agricultural
and industrial production, and the environment. - It is a derivative of the discovery of the
structure of DNA in 1955 that revolutionized
biology. - Techniques of biotechnology include cloning,
genetically modified varieties, genetic
screening, - USDA Definition Agricultural biotechnology is a
collection of scientific techniques, including
genetic engineering, that are used to create,
improve, or modify plants, animals, and
microorganisms. Using conventional techniques,
such as selective breeding, scientists have been
working to improve plants and animals for human
benefit for hundreds of years. Modern techniques
now enable scientists to move genes (and
therefore desirable traits) in ways they could
not before - and with greater ease and precision.
3Lessons of medical biotechnology
- major applications in terms of drugs,
diagnostics, and production of materials (like
insulin). - The industry evolved around the universities.
Many major technologies were developed in
universities and transferred to companies.
Examples Genentech was originated by scientists
in Stanford and UCSF. Amgene by scientists from
UC San Diego, and Chiron by scientists at U.C.
Berkeley. - Process of technology transfer from universities
to the private sector sometimes evolved transfer
of technology to a start-up. The startup either
grew to become a major company or was taken over
by Big Pharma.
4The Promise of Biotechnology
- Combating human diseases
- Promoting human health - Researchers are creating
ways to boost the nutritional value of foods
using biotechnology. - Combating animal diseases - Biotechnology helped
produce a vaccine that protects animals in the
wild against rabies and a vaccine for "shipping
fever" of cattle, the biggest killer of beef
cattle in feedlots. - Fighting hunger by resisting plant diseases and
increasing crop yields - Biotechnology can help
farmers increase crop yields and feed even more
people. For example, by increasing areas where
crops can grow and fighting crop diseases. - Helping the environment by reducing pesticide use
- Biotechnology can help farmers reduce their
reliance on insecticides and herbicides.
5Types of Agbiotech
- 1) pest control biotech, including resistance to
pests (bT corn), and resistance to pesticides
(Roundup ready soybean). - Yield-increasing varieties that are not
pest-control related. For example,
drought-tolerant varieties. - Quality enhancing varieties that include longer
shelf life, better taste - 4) Nutritionally-improved food (cholesterol free
egg) - 5) Fine chemicals and materials (silk, organic
plastic, oils)
6The Slow Evolution of Agbiotech
- While the first application of medical biotech
were in the 1980s, the commercialization of ag
biotech occurred in the late 1990s. There are
several reasons - ? In ag biotech, one deals with many species, in
medical biotech, with one species. - ? There is a much larger willingness to pay for
drugs than for food. - ? There is more tolerance for risk when it come
to production of medical than food. Furthermore,
ag biotech is produced in the field, and requires
extra care. - Much more research money has been allocated to
medicine than crops
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8Early Application of Agbiotech
- Early application of agbiotech includes Bt and
Roundup ready inserted varieties in major field
crops (corn, soybeans, tobacco) Virus resistant
papaya, and FlavorSaver Tomatoes. - The Bt varieties mostly reduce pesticide use in
the U.S., but dont affect yield. - There have been some drift of genetic material
towards wild corn. - There are some indicators of resistance-buildup.
9The Case for Agbiotech
- Agbiotech presents opportunities for
environmental quality improvement and is a source
of risk. - With good management, it has an important role in
the future of agriculture. - Much of the value of agbiotech is in the
developing world. There is a big debate whether
it is appropriate there. It will be addressed
below.
10Attitudes toward Agbiotech
- There has been significant resistance for the
introduction of agbiotech, especially in Europe. - Agbiotech entails perceived risks, but benefit to
consumers of the early applications are
non-apparent. - There is lack of confidence in government
assurance, and in technology in Europe,
especially after mad cow disease. - Agbiotechnology may be opposed indirectly by
individuals that benefit from substitute
products. E.g. pesticide manufacturers.
11Presumed Points of Failure
- Productivity Biotechnology aims to solve
problems of the North will not make a difference
in the South. - Access Biotechnology is controlled by
corporations will not be accessible on feasible
terms to poor peasants. - Risks Damage to environment and human health,
contamination of native genetic materials, and
loss of crop biodiversity
12Productivity Yield-Increasing Potential
- Yield potential output x (1 - damage)
- damage f (pest, pest control)
- Combination of high pest pressure and minimal
existing use of pest control ? potential for
yield-increasing effect - Attractive features of pest-control agricultural
biotechnologies - Simplicity of use
- Reduction in use of chemicals or labor
13Productivity Evidence for Bt Cotton Gains
- Bt cotton in
- United States yield effect 0 15
- China yield effect 10
- South Africa yield effect 20-40
- India yield effect 60 80
- In every country have reduction in chemical usage
14The Impact of Bt Cotton in India
- Bt cotton is used to provide resistance to the
American bollworm (Helicoverpa armigera). - The technology was developed by Monsanto and was
introduced in collaboration with the Maharashtra
Hybrid Seed Company (Mahyco). - Field trials with these Bt hybrids have been
carried out since 1997 and, for the 2002/03
growing season, the technology was commercially
approved by the Indian authorities.
15Our study
- For our analysis, we use data from on-farm field
trials that were carried out during the 2001/02
growing season as part of the regulatory
procedure. - In 2001, field trials were carried out on 395
farms in seven states of India. These trials were
initiated by Mahyco and supervised by the
regulatory authorities.
16Experimental design
- Three adjacent 646 m2 plots were planted the
first with a Bt cotton hybrid, the second with
the same hybrid but without the Bt gene (non-Bt
counterpart), and the third with a different
hybrid commonly used in the particular location
(popular check). - All three plots were managed by the farmers
themselves, following customary practices. - This setup allows reducing the effects of
differences in agroecological conditions and
managerial abilities when making technological
comparisons.
17The actual data source
- In addition to the regular trial records, more
comprehensive information was collected for 157
farms on agronomic aspects and farm and household
characteristics. - Observations from these 157 farms constitute the
data basis for this analysis. - They cover 25 districts in three major
cotton-producing statesMaharashtra and Madhya
Pradesh in Central India and Tamil Nadu in the
South. Plot-level input and output data were
extrapolated to 1 hectare to facilitate
comparisons.
18Results
- Bt hybrids were sprayed three times less often
against bollworms than the conventional hybrids. - On average, insecticide amounts on Bt cotton
plots were reduced by almost 70, which is
consistent with studies from other countries. - At average pesticide amounts of 1.6 kg/ha (active
ingredients) on the conventional trial plots,
crop damage in 2001/02 was about 60. Bt does not
completely eliminate pest-related yield losses.
19Results II
- Average yields of Bt hybrids exceeded those of
non-Bt counterparts and local checks by 80 and
87, respectively. - 2001/02 was a season with high bollworm pressure
in India, so that average yield effects will be
somewhat lower in years with less pest problems.
20Insecticide Use and Crop Losses with and without
Bt Technology
21Yield and pesticides use comparisons
22Predicted yield effects of pest controlling
Biotech
23Access
- Intellectual Property Rights (IPR)
- Registrations
24Access Biotechnologies in the South
- Most IP is generated by research in the North
- Transfer of public sectors rights to the private
sector provides incentives for development and
commercialization - Companies have little incentive to invest in
applications specific to the South
25Access Biotechnologies in the South
- Companies are willing to give technologies for
use in South good PR - Companies worry about liability, transaction
costs - Universities with rights to technology will also
be open to transferring to South applications - Needed institutional mediation IP clearinghouse
26Access Objectives of clearinghouse for IPR
- Reduce search costs to identifying set of
technologies accessible - Reduce transaction cost for the commercialization
of innovations - Increase transparency about ownership of IPR
- Provide mechanisms to manage negotiation of
access to IPR - Improve technology transfer mechanisms and
practices (mostly in public sector institution)
27Access Model of a clearinghouse for IPR
Member organizations
IP providers
Non-member organizations
Direct licensing transactions
Assignment, license, or option for full or
limited fields of use
Re-packaging
Pooled sub-licensing
Single patent sub-licensing
IP users
Non-member IP users
Non-member IP users
Member organization IP users
28Access Reducing Regulatory Constraints
- Registration should be efficient. Excessive
requirements may be used as a source of political
economic rent seeking. - Borders are arbitrary. Countries can take
advantage of regulatory clearances granted
elsewhere and concentrate on addressing unique
local problems and risks. - Countries should develop regional alliances for
regulation and establish mechanisms for easy
transfer of regulatory information.
29Environment
- Risks
- Agricultural biodiversity
30Environment Sound Basis for Risk Analysis
- Is the Precautionary Principle a sound basis for
risk analysis? - There are always trade-offs between risks and
benefits, and between risks and risks. - In Africa, does risk of genetic contamination
exceed risk of starvation? - Agricultural biotechnology should be evaluated in
comparison to pesticides and other real
alternatives. - In tropics, increased productivity would reduce
pressure for deforestation.
31Gmos are not perfect-
- Gmos have problems-resistance buildup, damage to
secondary pests, genetic contamination. - Refugia, monitoring of impacts, restriction of
use in some locations can address these problems
partially-but alternatives have problems and
risks that have to be considered. - Agricultural biotech is in its infancy- built up
of human capital and accumulation of -will lead
to eliminations of many bug and lead to better
technologies
32Environment Sound Basis for Risk Analysis
- Risks and benefits should be quantified.
- Sound reliability factorsi.e. confidence
intervalsshould be used to standardize risk
estimates.
33Environment Relative to Modern Breeding Biotech
Can Enhance Crop Biodiversity
- Main premise Agbiotech allows minor modification
of existing varieties and under appropriate
institutional setup can be adopted while
preserving crop biodiversity - Conventional breeding involves often massive
genetic changes, and adjustments to accommodate
biodiversity are costly and - Well functioning IPR system can lead to crop
biodiversity preservation - Field data support this claim
34Table 1. Number of available varieties for
different GM technologies in selected countries
(2001/2002)
35Environment Biodiversity scenarios in the field
- Strong IPRs, strong breeding sector, and low
transaction costs. (US) Private technology owner
will license the innovation to different seed
companies, who incorporate it into many or all
crop varieties, so that crop biodiversity is
preserved. - Strong IPRs, strong breeding sector, but high
transaction costs. (CGIAR) If an agreement cannot
be reached, companies will bypass breeding
sector, directly introduce GM crop varieties that
are not locally adapted.
36Environment Biodiversity scenarios in the field
- Weak IPRs and a strong breeding sector. (China)
Many different GM varieties are available Farmers
and consumers are beneficiaries. SR social
optimum. - Weak IPRs and a weak breeding sector. (Africa) If
foreign GM crop varieties are even introduced,
are done directly without adaptation. A loss of
local crop biodiversity.
37Biotech Could Enhance Crop Biodiversity
- Conventional breeding led to wholesale
replacement of land races with elite line
monocultures - Biotechnology could provide precise improvements
to traditional land races - Could lead to reintroduction of new
technologically competitive land races -
Jurasic garden
38Conclusions
- Agbiotechnology has significant potential for
developing countries the challenge is to realize
that potential - Productivity yield effect of biotechnology tends
to be larger in developing countries - Access institutions can reduce IP and regulatory
costs for developing countries - Risks crop biodiversity can be preserved and
could even be restored with biotechnology
39Ag bio tech is only part of the solution
- Ag biotech is more than Gmos.
- It will evolve- alternative molecular approaches
will be developed-but - knowledge will not be accumulated without
experience - Development may be dependent on public and
private sector funding - Ag biotech must be pursued as part of a portfolio
of technology and knowledge tools aiming to
enhance productivity and environmental
sustainability of agriculture.
40Consider
- 250 million Americans are the guinea pigs for
agricultural biotechnology. Northern countries
also took the risk with cars and with modern
chemicals. - Africa missed the Green Revolution will it also
miss the Gene Revolution?