View of Clinical Research Center Center for Innovative Medicine MUHC RI Glenyards Campus

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View of Clinical Research CenterCenter for
Innovative MedicineMUHC RIGlenyards Campus

• January 2005

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Prepared and presented by

• Nancy E. Mayo BSc(PT), MSc, PhD
• James McGill ProfessorClinical Epidemiology,
  GeriatricsSchool of Physical and Occupational
  Therapy

Representing the many researchers who contributed
ideas and project plans for
Innovation in Reducing Disability and Enhancing
Lifes Quality
Special acknowledgement to Richard Riopelle
(Neurosciences) for help in conceptualization
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Health Care System

• Promotes.

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Prevention
Care
Restoration
Wellness
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CRC will be the Research Arm providing the
evidence for the activities of the Health Care
System
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Prevention
Care
Restoration
Wellness
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Innovation in Reducing Disability and Enhancing
Lifes Quality

• Disability is an umbrella term referring to
• Impairments of body structure and function
• Limitations in activities required for daily life
• Restrictions in participation in lifes roles
• Quality of life (Health-related quality of life
  in health context)
• Value assigned to duration of life as
• Modified by impairments, functional states,
  perceptions and opportunities as
• Influenced by disease, injury, treatment and
  policy

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Innovation in Reducing Disability and Enhancing
Lifes Quality
Development and Evaluation Novel interventions
for restoration of function Prehabilitation Nutr
itional approaches Exercise training Performance
enhancementStandardized testing and assessment
including imagingMethodological research
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Innovation in Reducing Disability and Enhancing
Lifes Quality
Cancer nutrition and exercise trainingPresurgical
conditionning Arm dysfunction in breast
cancerLymphedema prevention and
treatmentDelirium and cognitive failurePerson
and family stressPalliative care research
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Innovation in Reducing Disability and Enhancing
Lifes Quality
Predictive value of endothelial dysfunction in
explaining response to exercise and future events
for persons with stroke and to determine whether
improvements in the intima-media thickness of the
carotid artery can be achieved and is related to
these outcomesOptimizing outcomes of elderly
persons undergoing cardiac surgery..
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Innovation in Reducing Disability and Enhancing
Lifes Quality
ChildhoodDisability
Pulmonary rehabilitationVentilator
independenceDevelopment of methods to measure
physical activity
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Innovation in Reducing Disability and Enhancing
Lifes Quality
ChildhoodDisability
Osteoporosis researchSarcopeniaNutritionResista
nce trainingMechanisms of joint
dysfunctionJoint friendly exercise regimens
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Innovation in Reducing Disability and Enhancing
Lifes Quality
ChildhoodDisability
NutritionExerciseMorbid obesitySurgical
interventionPrehabilitationPsychosocial
interventionDevelopment of measures
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Innovation in Reducing Disability and Enhancing
Lifes Quality
ChildhoodDisability
Stroke Strategies to enhance exercise tolerance
(stroke and others such as multiple
sclerosis)upper limb use, mood, and
cognitionInterventions to enhance physical
activity, driving capacity and performance and
communicationPrograms for caregiver
well-beingand community participationLink
between brain and behaviourImaging
researchMonitoring brain activity
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Innovation in Reducing Disability and Enhancing
Lifes Quality
ChildhoodDisability
Risk factors for neurological damage Novel
interventions to enhance outcome and reduce
family distress. Specific populations include
children with cerebral palsy, congenital skeletal
malformations, specific language impairment, and
cognitive/affective disorders including autism,
depression and conduct disorder Application of
sophisticated neuro-imaging techniques to better
understand the underlying mechanisms of brain
injury, its aetiology and evolution
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Innovation in Reducing Disability and Enhancing
Lifes Quality
ChildhoodDisability
Development testing of performance enhancement
protocols
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Innovation

• Unite researchers from a wide variety of
  disciplines around common projects focused on
  disability in all its vast manifestations
• New research groups will develop spontaneously
• Disability research will expand beyond
  traditional focus of last resort
• Both intrinsic (biological, personality traits)
  and extrinsic (environmental attributes, health
  services) factors will be considered as important
  determinants of participation and quality of life
• Capacity for the fundamental research to be done
  in the same environment as research on clinical
  populations is unprecedented advantage to create
  population-relevant solutions
• Capacity to admit persons with disabilities to
  research beds during testing and intervention
  will greatly expand the scope and feasibility of
  disability research
• Opportunity to conduct multidisciplinary
  randomized trials in the area with linkage to
  health services and economic data will be
  considerably enhanced.