RHABDOVIRIDAE

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RHABDOVIRIDAE

• PETER H. RUSSELL, BVSc, PhD, FRCPath, MRCVS
• Department of Pathology and Infectious Diseases,
  The Royal Veterinary College,
• Royal College Street,
• London NW1 OTU.
• E-mail Web site

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LEARNING OBJECTIVESStudents should be able to

• Describe rabies pathogenesis in mammals,
  including bats
• Relate rabies epidemiology in different countries
  to the control measures used.
• Name the four requirements in the rabies control
  strategy recently introduced as an alternative to
  quarantine in the UK.

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FAMILY CHARACTERISTICS

• (Rhabdo rod )

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RABIES

• DISEASE PATHOGENESIS
• Notifiable zoonotic rare in UK but several
  cases have been veterinarians!

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RABIES

• DISEASE PATHOGENESIS
• Non-fatal infections are rare but skunks and
  foxes may recover dogs can have mild symptoms,
  recover and remain as excretors. Recovered
  animals have antibodies. These infections are
  important in spreading the virus in the
  environment.

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RABIES

• ANTIGENICITY only one type required in vaccine

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RABIES

• HOST RANGE All mammals are susceptible
  including bats

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RABIES

• CONTROL
• The strategy depends on whether rabies is endemic
  or whether the country is free of virus.
• Virus-free countries

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RABIES

• CONTROL
• Virus endemic countries

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RABIES

• CONTROL
• In humans

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Summary

• Rabies targets the nervous system and brain
  causing a fatal infection transmitted by biting
  as virus in saliva zoonotic.
• Rabies-free countries aim to keep rabies out by
  quarantine countries with endemic rabies in
  wildlife control rabies by reducing wildlife
  numbers /- vaccination of wildlife.
• In the UK, the Pet Travel Scheme has been
  introduced to replace quarantine but for
  movements between specified countries only.