Coming Attractions Coming Soon to your local high school Emerging Technologies in Science: Tissue En

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Coming AttractionsComing Soon to yourlocal
high school Emerging Technologies in Science
Tissue Engineeringby Mary Coleman Overbrook
High School
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General Overview

• The Research Experience itself
• My role in the Tissue Engineering Lab
• Conclusions What I Learn
• Curriculum Project

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Dr Suns Computer Aided Tissue Engineering Lab

• Computer aided Tissue Engineering lab was
  composed of a team working on the bone-tissue
  interface with different aspects of the problem.
• Overall goal of TE is to reconstruct or correct
  some limiting aspects of the human condition.
• Quest for the Fountain of Youth is here.

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Tissue Engineering

• This technology involves removing cells from a
  healthy
• part of the body and placing them in an area of
  diseased or damaged tissue in order to improve
  certain body functions.
• Currently, it is used to treat defects in
  cartilage, and, if successful, could eventually
  help treat osteoarthritis.
• Hence, the topic of osteoarthritis and the
  knee joint cartilage is selected for research
  study.

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STRUCTURE OF THE KNEECan you locate the areas
of the knee where tissue engineering will be
useful?
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My Role in the Lab

• Computer Aided Tissue Engineering begins with the
  computer and learning Mimics Software
• Made a 3-D model of the Knee joint using Mimics
  (Show Model)
• Observed extruder making scaffolds for tissues
• Presented a Research Paper on Knee with Notebook
  of articles used for future use by staff

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Mimics Software 3-D Image Used to Construct Mold
of Knee Joint
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Simulation of Cartilage Cell Seeking Bone
ScaffoldGraphic Courtesy of Andrew Darling, Dr
Sun Laboratory, Drexel University
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What I Learned from Research
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School District of PhiladelphiaCurriculum
Project Standards

• Pa Standards for Science and Technology
• Living Environment 14.7  Students will
  understand that increased human life expectancy
  has resulted from advances in health technology,
  agriculture, and manufacturing. (14.7.1)
  Understand that advances in medical science,
  biotechnology, improved sanitation enhances
  quality of life of humans.
• Science and Technology Standard 3.6.10 99 (A) 
  Apply knowledge of Biomedical Technology
  applications in designing a solution to a simple
  medical problem.  (B)  Apply appropriate
  instruments and apparatus to examine a variety of
  objects and processes. 

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Curriculum Project(excerpts only- Refer to hand
out for complete Unit)

• Overarching Unit Goal
• Is it possible for Biotechnology through
  Tissue Engineering to reconstruct knee cartilage
  if has worn out or been damaged?

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Curriculum Project Unit Long Understanding Goals

• How does a normal knee joint work ? (include
  tissues, bones, muscles)
• What happens in the functioning of a diseased
  joint ?
• How are people of different ages affected by knee
  injuries and what corrective measures are taken?
• What types of bone scaffolds can different cell
  types be grown on?

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Introductory Performance

•  a. Students will view video  Dateline current
  clinical cases on knee replacements. 
• b. Students will break up into groups and
  discuss case histories and find out what
  experiences people have had with knee injuries 
• c.  Invite speaker from Drexel Medical School to
  talk on local knee surgeries and injuries. 
• On-going Assessments for Introductory Performance
• a. Students will write a 2 paragraph reaction to
  video.  Agree or disagree with clinical cases. 
• b.  Students will write up what they know and
  want to know about knee injuries  (KWL)
•  

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Guided Inquiry PerformanceUnderstanding
Performances

• Students will construct a model showing bones,
  muscles, and tendons of the knee joint using
  clay or construction paper
• Students will examine a knee joint model showing
  normal, mild, moderate, and severe knee joint
  damage.
• Students will use the microscope to examine the
  different cell types.
• Students will go online to various web sites to
  see Electron Micrographs of different cell types

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On Going Assessments forUnderstanding
Performances

• Students will present their knee joint model
• Students will present ideas on the various
  conditions of knee damage and what the
  consequences are.
• Students will draw cells from using the
  microscope and speculate on how tissues are made

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Curriculum ProjectCulminating Performance

• Students will take a field trip to tissue
  engineering
• lab and will make a mold
• Students will complete KWL with what they learned

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Why should High School Biology Students learn
about Emerging Technologies?

• Future Careers in the multidisciplinary fields of
  Biology and Engineering that will solve relevant
  scientific problems
• Become better prepared for College Studies
• Greater understanding of future developments in
  curing a disease or condition where tissue
  engineering may affect your life.
• Anticipate fewer deaths due to lack of organs for
  transplants may be possible through tissue
  engineering
• Increased application and development of computer
  skills

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Acknowledgements

• Many thanks to Dr. Sun and his graduate students
  for allowing me into their lab
• Dr. Corey Ruth Keystone Orthopedics, Graduate
  Hospital for providing Knee Models and for his
  interest in working with alternative therapies
  for knee replacements
• RET Program at Drexel Joanne Ferroni for the
  excellent assistance and training on Power Point.
• All my RET colleagues who gave me extra help and
  assistance

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The RET Experience Continues.at your local high
school Beam me up, Scotty.
(Star Trek)
The End
2003
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Simulation of Cartilage Cell Seeking Bone
Scaffold Graphic courtesy of Andrew Darling,
Dr. Sun Laboratory- Drexel University