Integumentary System

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Integumentary System
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Review of Anatomy
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Function of Skin
1. Barrier physical, immunological 2. Sense
Organ touch, temperature, pain 3. Temperature
Regulation vasomotor, pilomotor, sweat glands 4.
Metabolism vitamin D
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Aging of the Skin
Not a question of morbidity or mortality but of
vanity psychology of self-image 7 Billion /
yr. In U.S. (skin care products)
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Age Related Changes
Overall Changes Thinner Skin Loss of Dermal
Papillae- epidermis held less firmly to
underlying dermis Epidermal Changes Thinner
with age ? Age (liver) spots
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Age Related Changes
Dermal Changes Thinner with age - changes in
type and amount of collagen Synthesis and
secretion by fibroblasts Decrease number of
fibroblasts with age Cross-links of elastin -
less elastic leads to sags and
wrinkles Reduction in sweat glands Reduction in
number of sebaceous glands Reduction in Hair
Growth (except ear and nose)
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Age Related Pathologies
1. Lentigo - age spots, senile freckles 2.
Senile Angioma - port-wine stains 3. Senile
(actinic) Keratosis - red scaly patches may be
precancerous (squamous cell carcinoma) 4.
Decubitus Ulcers - pressure sores, bed
sores immobility, thinner dermis, less
subcutaneous fat 5. Neoplasms - squamous cell
carcinoma - basal cell carcinoma - melanoma
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Wrinkles
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Wrinkle Formation
Decrease in dermal papillae- loosens
skin Thinning of Dermis- Change in
Collagen Alteration of GAGs with
irradiation Chondroitin Sulfate Thinning of
epidermis - creates fold