DEATH

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Characteristics of AEGLs
HAZARD ASSESSMENT
Effects
Threshold Levels
DEATH

• Increasing likelihood of death

• Impairment of ability to escape
• Increasing severity of irreversible or other
  serious long-lasting effects

DISABLING

• Increase in notable discomfort
• Increasing severity of reversible effects (with
  or without signs/symptoms)

DISCOMFORT
Increasing complaints of objectionable odor,
taste, sensory irritation or other mild,
non-sensory or asymptomatic effects
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Example 1 AEGL Values for Carbon Monoxide
(ppm)
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Example 2 AEGL Values for Hydrogen Sulfide (ppm)
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AEGL Vulnerable/ Safe Zones
Release Site
Death (AEGL-3)
Disability (AEGL-2)
Discomfort (AEGL-1)
DETECTABILITY
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Effect of AEGL Value on Vulnerable Zone Example
Case 1 Compound X AEGL 2 0.001 mg/m3/60 min/
3.4 mph wind speed, rural terrain, F atmospheric
stability, 100 lb release (10 lbs/min) Vulnerable
Zone 9.0 miles Case 1 Compound X AEGL 2
0.01 mg/m3/60 min/3.4 mph wind speed, rural
terrain, F atmospheric stability, 100 lb release
(10 lbs/min) Vulnerable Zone 1.3 miles
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Chemical Priority List for AEGL Development
Organization Lists Used for the Selection of ( )
Priority Chemicals ATSDR Agency for Toxic
Substances and Disease Registry (36) A ATSDR
"Top 20" Toxicology Profile Chemicals (6) B
Medical Management Guide Chemical (7) C
Chemicals with an ATSDR Toxicology Profile
(33) DOD Department of Defense (18) A
Chemical Weapons Convention Schedule 1, 2, or 3
(2) B Strategic Environmental Research and
Development Program (SERDP) Chemical (7) C
Air Force Installation Restoration Program
Chemical (10) D Army Toxicity Summary
Chemical (9) E Non-Stockpile Chemical Warfare
Substance (4)
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Chemical Priority List for AEGL Development
DOE Department of Energy Subcommittee for
Consequence Assessment SCAPA and Protective
Action (80) A TEEL chemical with vapor
pressure gt3.2 mm (35) B TEEL chemical with
TEEL-3 lt25 ppm (9) C Lab List (9) E Other
TEEL chemicals (39) DOJ Department of Justice
Office of Justice Programs (23) A "High"
concern Toxic Industrial Material (TIM) (3) B
"Medium" concern TIM (19) C "Low" concern TIM
(10) DOT Department of Transportation Emergency
Response Guidebook (106) A Department of
Transportation Emergency Response Guidebook
Isolation Table (46) B Other ERG (50) C
Top 150 Hazardous Material transported by rail
(31)
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Chemical Priority List for AEGL Development
EPA Environmental Protection Agency (95) A
Environmental Protection Agency Clean Air Act
112r (Risk Management Program) (10) B CAAA
112b Chemical (Hazardous Air Pollutant) (40) B
April 1, 1994 list submitted by OAQPS (HAP
with current acute toxicity interest) (9) C
Environmental Protection Agency Superfund
Chemical (24) D EPA Extremely Hazardous
Substance List ( EHS solid with RTECS LC
data) (8) E CAAA 112r Proposed Update
Chemical (16) F Office of Pesticides
Nomination (28) OSHA Occupational Safety and
Health Administration (43) A OSHA Process
Safety Management Chemical (38) B OSHA
nomination for current acute toxicity interest
(6)
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Chemical Priority List for AEGL Development
OTHER C Chemical Market Reporter list D
Dutch chemical list (36) F French chemical
list (8) G German chemical list H High
Production Volume chemical challenge list I
Illinois chemical list J New Jersey chemical
list K Korean chemical list (6) N New
York chemical list P Active U. S. Pesticide
ingredient chemical R Russian chemical list
(5) S Seveso Annex III International Seveso
Convention List
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AEGL Chemical Status ???????????????? ??????
??????? ??????????? ???? ??????????
AEGL Chemical Priority (108 Chemicals)
STATUS NUMBER OF CHEMICALS Final 25 Interim 5
4 Proposed 43 Draft Holding 15
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Final AEGL Chemicals (18)
1,1-Dimethyl hydrazine Methyl hydrazine Aniline Hy
drogen Cyanide Phosgene Diborane
HCFC 141b 1,2-Dimethyl hydrazine Arsine Propylen
e glycol dinitrate Agent GA (Tabun) Agent GB
(Sarin)
HFC 134a Agent GD (Soman) Agent GF Agent
VX Sulfur mustard
National Academy of Sciences (Free) Publications
on-line of Final AEGLs http//www.nap.edu/catalog
/10043.html http//www.nap.edu/catalog/10522.html
http//www.nap.edu/catalog/10672.html (nerve
agents and sulfur mustard)
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Interim AEGL Chemicals (48)
Carbon tetrachloride Methanol 1,1,1-Trichloroethan
e Ethylene oxide Propylene imine Propylene
oxide Trimethyl chlorosilane Dichlorodimethyl
silane Trichloromethyl silane Isobutyronitrile Acr
ylic acid 2,6-Toluene diisocyanate Allyl
amine Propionitrile Ethylene diamine Allyl alcohol
Chloromethyl methyl ether Toluene Cyclohexylamine
Phenol Furan trans-Crotonaldehyde Methacrylonitril
e Tetrachloroethylene Ethyleneimine cis-1,2-Dichlo
roethylene cis-trans -1,2-Di-chloroethylene Hydraz
ine Boron trifluoride Tetranitromethane 2,4-Toluen
e diisocyanate HFE-7100
Perchloromethyl mercaptan Methyl
isocyanate Carbon monoxide cis-Crotonaldehyde Hydr
ogen chloride Hydrogen fluoride Fluorine Chlorine
Hydrogen sulfide Uranium hexafluoride Chlorine
trifluoride Phospine Chlorine dioxide Boron
trichloride Nickel carbonyl Iron pentacarbonyl
Proposed AEGL Federal Register Notices with
Technical Support Document Links http//www.epa.g
ov/fedrgstr/EPA-TOX/2002/February/Day-15/ http//w
ww.epa.gov/fedrgstr/EPA-TOX/2000/December/Day-13/t
31730.htm http//www.epa.gov/fedrgstr/EPA-TOX/2000
/June/Day-23/ http//www.epa.gov/fedrgstr/EPA-TOX/
2001/May/Day-02/t11001.htm http//www.epa.gov/fedr
gstr/EPA-TOX/2000/March/Day-15/t6397.htm http//ww
w.epa.gov/fedrgstr/EPA-TOX/1997/October/Day-30/t28
642.htm
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Proposed AEGL Chemicals (33)
Formaldehyde Acetone Chloroform N,N-Dimethylformam
ide Benzene Methyl mercaptan Vinyl
chloride Carbon disulfide Acetone
cyanohydrin Methyl ethyl ketone
Trichloroethylene Monochloroacetic acid Peracetic
acid Epichlorohydrin Acrolein Piperidine 1,4-Dioxa
ne Xylenes Sulfur dioxide Titanium tetrachloride
Ammonia Phosphorus trichloride Bromine Jet Fuels
(JP5 8) Phosphorus oxychloride Hydrogen
bromide Nitric oxide Nitric acid Nitrogen dioxide
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Draft and Holding AEGL Chemicals (8)
Tetramethyl lead (H) Methyl chloroformate Isopropy
l chloroformate Propyl chloroformate
Cyanogen chloride Acrylylchloride Sulfur
tetrafluoride Arsenic Trichloride
Methylene chloride Sulfur Trioxide Sulfuric
acid Oleum
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Chemical Classes- Value of Chemical Classes
Approach

• Utilize "universal" pharmacokinetic and
  pharmacodynamic information from chemical class
  chemicals
• Identify chemicals for which AEGLs may be
  developed together (including chemicals from
  differing classes, such as chemicals that release
  HCl upon hydrolysis).
• Provide a range of AEGL levels for purposes of
  developing chemical class personal monitors.
• Provide a chemical class approach to protective
  equipment, decontamination and other
  counter-terrorism activities related to toxic
  chemical release (DOJ approach).
• Present for local use a systematic concept of
  acute toxicity of chemical classes. Illustrate
  the universe of acutely toxic chemicals.
• Allow for inherently safer chemistry suggestions,
  based on substitution or modification of current
  practices.
• Provide suggestions for revision of existing
  regulatory chemical lists (eg RMP)
• Provide Risk Management options

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CHEMICAL CLASSES
473 AEGL CHEMICALS IN 66 CHEMICAL CATEGORIES ( )
NUMBER OF CHEMICALS PER CATEGORY
ACID HALIDES (28) ALCOHOLS (6) ALDEHYDES
(8) ALUMINUM COMPOUNDS (1) AMIDES (6) AMINES
(31) ANHYDRIDES (2) ANILINES (4) ANTIMONY
COMPOUNDS (2) ARSENIC COMPOUNDS (16) AZO
(2) BARIUM COMPOUNDS () BERYLLIUM COMPOUNDS
() BORON COMPOUNDS (5) BROMINE COMPOUNDS
(5) CADMIUM COMPOUNDS () CARBAMATES
(6) CHLORINE, INORGANIC (4) CHLOROSILANES
(16) CHROMIUM COMPOUNDS (1) COBALT COMPOUNDS
() COPPER COMPOUNDS () EPOXIDES (6) ESTERS
(12) ETHERS (17)
FLUORINES, INORGANIC (7) GERMANIUM COMPOUNDS
(1) HALOGENS, INORGANIC (54) HYDRIDES
(1) HYDROCARBONS, ALIPHATIC (10) HYDROCARBONS,
AROMATIC (14) IMINES (2) INORGANIC ACIDS
(12) ISOCYANATES (14) KETONES (10) LEAD COMPOUNDS
(2) MANGANESE COMPOUNDS (1) MERCAPTANS
(6) MERCURY COMPOUNDS (4) METAL CARBONYLS
(2) NICKEL COMPOUNDS (1) NITRILES (19) NITRO
COMPOUNDS (7) NITROGEN COMPOUNDS, INORG
(8) NITROSO (1) ORGANIC ACIDS (9) OSMIUM
COMPOUNDS (1)
OXIMES (1) OXYGEN COMPOUNDS, INORG (2) PEROXIDES
(3) PHENOLS (10) PHOSPHATE THIOPHOSPHATES
(24) PHOSPHONATE ESTERS (7) PHOSPHORAMIDATES
(2) PHOSPHORUS COMPNDS, OTHER (16) SELENIUM
COMPOUNDS (2) SILICON COMPOUNDS (2) SULFUR
COMPOUNDS (20) TANTALUM COMPOUNDS (1) TELLURIUM
COMPOUNDS (1) TETRACYCLIC COMPOUNDS (1) THALLIUM
COMPOUNDS (1) TITANIUM COMPOUNDS (3) TUNGSTEN
COMPOUNDS (1) VANADIUM COMPOUNDS () ZINC
COMPOUNDS ()
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Nitriles Chemical Class (AEGL-3, 2, 1 60 min)
R1)(R2)(H) C C (CN)(R4)(R5)
Hydrogen cyanide (RMP) (for comparison) AEGL 3,
2, 1 (60 min) 15, 7.1, 2.0 ppm Acetonitrile Acet
one cyanohydrin AEGL 3, 2, 1 (60 min) 15, 5.4,
0.84 ppm Isobutyronitrile (RMP) AEGL 3, 2, 1 (60
min) 20, 6,6, NR ppm Lactonitrile Propionitrile
(RMP) AEGL 3, 2, 1 (60 min) 39, 7.4, NR
ppm Acrylonitrile (RMP) Chloroacetonitrile Formale
dehyde cyanohydrin Malononitrile Methacrylonitrile
(RMP) AEGL 3, 2, 1 (60 min) 3.4, 1.1, NR
ppm Sodium cyanide (for comparison) Cyanogen Cyano
gen bromide Cyanogen chloride (RMP) Cyanogen
iodide O-Chlorobenzylidene malononitrile Bromobenz
yl cyanide