Aarkstore - Stem Cell Research Products - Opportunities, Tools, and Technologies (1)

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Category Healthcare
Stem Cell Research Products - Opportunities,
Tools, and Technologies

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Executive Summary
Stem cells are primitive cells found in all
multi-cellular organisms that are characterized
by self-renewal and the capacity to differentiate
into any mature cell type.Stem cells are still
a relatively new discovery, as the first mouse
embryonic stem cells were derived from embryos in
1981, but it was not until 1995 that the first
successful culturing of embryonic stem cells from
non-human primates occurred and not until
November 1998 that a technique was developed to
isolate and grow embryonic stem cells from human
blastocysts. In 2006, induced pluripotent stem
cells were produced for the first time from mouse
cells and in 2007 they were produced from human
cells. Furthermore, it was not until 2008 that
the first full transplant of a human organ grown
from adult stem cells was performed when a
section of trachea was successfully transplanted
into an adult woman in Spain.
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Executive Summary
As of 2014, several broad categories of stem
cells exist, includingEmbryonic stem cells,
derived from blastocystsFetal stem cells,
obtained from fetusesPost-natal stem cells,
derived from newborn tissuesAdult stem cells,
found in adult tissues including Hematopoietic
stem cells, Mesenchymal stem cells, and Neural
stem cellsCord blood stem cells, isolated from
umbilical tissueDental stem cells, derived from
deciduous teethInduced pluripotent stem cells,
reprogrammed from adult cellsCancer stem cells,
which give rise to clonal populations of cells
that form tumors or disperse in the bodyAnimal
stem cells, derived from non-human sources
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Executive Summary

The past 10 years have also witnessed the
production of novel stem cell types, including
piPSCs, R-NSCs, and VSELs. Together, this
evidence suggests that additional types of stem
cells will likely be discovered, each
representing new opportunities for research
product development. Clearly, laboratory research
into stem cell derivation, manipulation, and
application is rapidly expanding.To facilitate
research resulting from these advances, a large
and diverse stem cells products market has
emerged. Large companies selling stem cell
research products include Thermo Fisher
Scientific (now merged with Life Technologies),
BD Biosciences, EMD Millipore, Sigma Aldrich, and
STEMCELL Technologies, as well as over one
hundred other suppliers.
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Table of Content

• ABSTRACTII. BACKGROUND TYPES OF STEM CELLSA.
  Human Embryonic Stem Cells (hESCs)1. Early, 5-7
  days (totipotent)2. Gonadal Ridge, 6 months
  (multipotent)B. Fetal Stem Cells
  (pluripotent)C. Umbilical Cord Stem Cells
  (multipotent)1. Cord Blood 2. Cord Matrix
  (Whartons Jelly)D. Adult Stem Cells
  (multipotent)1. Hematopoietic Stem Cells 2.
  Mesenchymal Stem Cells
• 3. Neural Stem Cells4. Dental Stem Cells
  (multipotent)E. Cancer Stem Cells
  (multipotent)F. Induced Pluripotent Stem Cells
  (iPSCs)G. Novel (recently discovered and
  uncharacterized) Stem Cell Types1. Neural
  Rosette Cells (R-NSCs)2. Very Small Embryonic
  Like (VSEL) Stem Cells
• H. Stimulus-Triggered Acquisition of Pluipotency
  (STAP) Cells Unverified

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Table of Content
III. TIMELINE OF KEY STEM CELL EVENTSIV. STEM
CELL RESEARCH APPLICATIONSA. Regenerative
Medicine (Cell-Based Therapies)1. Diabetes
Mellitus 2. Cardiovascular Disease3.
Neurological Disease4. Autoimmune Disease5.
Hematopoietic Disease and Transplantation
Research 6. Orthopedic Repair7. Cancer
Research8. Birth Defect Research B. Drug
Development Discovery1. Assays to Aid Early
Stage Discovery2. Improved Prediction of Human
Responses3. Drug Development with Humanized
Mouse Models4. Genetically-Engineered Stem Cell
Lines for Screening5. Pluripotent Stem Cell
Lines for Target Validation and Drug Screening6.
Summary - Use of Stem Cells in Drug Development
Discovery
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Table of Content
V. KEY MARKET COMPETITORS PROVIDERS OF DIVERSE
STEM CELL PRODUCT LINES A. Thermo Fisher
Scientific (Recently Merged with Life
Technologies / Includes Invitrogen Brand)1. Stem
Cell Productsa. Isolation and Characterization
Productsb. Expansion and Differentiation
Products2. Collaborationsa. Invitrogen and
Cellartis ABb. Invitrogen and Novocellc.
Invitrogen and the Buck Instituted. Life
Technologies and Cellular Dynamics
Internationale. Life Technologies and iPS
Academia Japanf. Life Technologies and Harvard
Universityg. Life Technologies and DNAVEC
Corporation  B. BD Biosciences1. Stem Cell
Productsa. Isolation b. Culturingc.
Analysis2. Collaborations BD Biosciences and
STEMCELL Technologies
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Table of Content
VI. PRODUCT AREASA. Primary Antibodies B.
Bead-based Cell Separations SystemsC.
Fluorescent-based Labeling and DetectionD.
Protein Purification and Analysis Tools 1.
Protein Purification2. Stem Cell Protein
Analysis3. Quantitative ProteomicsE. DNA/RNA
Based Characterization1. Tools for DNA- and
RNA-based Characterization2. Stem Cell HLA
Typing3. Stem Cell Nucleic Acid Extraction and
Purification, PCR/qRT-PCR Reagents F. Isolation /
Characterization Services1. Stem Cell HLA Typing
Services2. Stem Cell Custom Services3. Stem
Cell Custom AntibodiesG. Stem Cell Culture Media
and ReagentsH. Growth Factors and Cytokines
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Stem Cell Research Products - Opportunities,
Tools, and Technologies Published Jun 2014
155 Pages Stem cells are primitive cells found
in all multi-cellular organisms that are
characterized by self-renewal and the capacity to
differentiate into any mature cell type. Price
Format Price
PDF 3495
Hard Copy 3545
Site License   4495
Enterprise Wide Licence 5495
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