Liver function tests

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Liver Function Tests
R. C. Gupta M.D. (Biochemistry) Jaip
ur (Rajasthan), India
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Liver perform a multitude of functions
The functions get deranged when liver is diseased
Assessment of functional status of liver
generally requires laboratory tests
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A number of tests are required to assess hepatic
function
All the tests need not be performed in every
patient
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The tests should be selected according to the
clinical symptoms and signs
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Serum bilirubin
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Plasma bilirubin comprises unconjugated bilirubin
and conjugated bilirubin
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Normal concentration of bilirubin in plasma is?
Conjugated? 0.1-0.4 mg/dl
Total? 0.2-1.0 mg/dl
Unconjugated? 0.1-0.6 mg/dl
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Jaundice
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Bile pigments in urine
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Urobilinogen in urine
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Bile salts in urine
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Haemolytic jaundice Hepatic jaundice Obstructive jaundice
Serum bilirubin (total) Raised Raised Raised
Serum bilirubin (unconjugated) Raised Raised Normal
Serum bilirubin (conjugated) Normal Raised Raised
Bile pigments in urine Absent Present Present
Urobilinogen in urine Raised Normal or decreased Absent
Bile salts in urine Absent Present Present
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Serum proteins and albumin globulin ratio
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Serum enzymes
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Prothrombin time
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Galactose tolerance test
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Hippuric acid test
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Bromsulphthalein test
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Immunological tests
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Blood ammonia
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Thank you