ROLIMUS 5MG TABLETS| EVEROLIMUS USES & SIDE EFFECTS

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ROLIMUS 5MG TABLETS EVEROLIMUS USES SIDE
EFFECTS

• Million Health Pharmaceuticals

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DESCRIPTION

• Rolimus 5mg is a derivative of Rapamycin
  (sirolimus) and works similarly to Rapamycin as
  an mTOR (mammalian target of rapamycin)
  inhibitor. It is normally used as an
  immunosuppressant to prevent rejection of organ
  transplants. 

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Brain carcinoma
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PRESCRIBING INFORMATION

• Rolimus 5mg tablet are mainly indicated for the
  treatment of Renal carcinoma.Rolimus 5mg
  tablet are mainly indicated for the treatment of
  Breast carcinoma.Rolimus 5mg tablet are mainly
  indicated for the treatment of Brain
  carcinoma.Rolimus 5mg is also used in various
  advanced stage cancer in stomach, intestines or
  pancreas.

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MECHANISM OF ACTION

• Everolimus is an mTOR prohibitor, joints at high
  compatibility to FK506 binding protein 12, via
  producing drug complex which inhibits the
  specific of mTOR.This inhibition decreases the
  activity of effectors downstream, that may cause
  blockage of cell progression from G1 into S
  phase, subsequently causes cell growth arrest and
  apoptosis

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ROLIMUS 5MG
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PRODUCT DETAILS

• Brand Rolimus Ingredients Everolimus Strengt
  h 5mgManufactured Cipla Ltd Package 10
  tablets 

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PHARMACOKINETICS

• PHARMACOKINETICS
• ABSORPTION
• The high plasma concentration time of Everolimus
  is 1 to 2 hours.The effect of food with Rolimus
  5mg that with heavy meal Reduction of systemic
  exposure to Rolimus 5mg10mg, and the high blood
  plasma concentration by 54.DISTRIBUTION
• Rolimus 5mg human plasma protein bound with the
  range of 74.METABOLISM
• The metabolism of Everolimus is occurred in
  liver, which is a substrate of CYP3A4.The
  metabolites of Everolimus Three monohydroxylated
  metabolite,

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DOSAGE MANAGEMENT

• In breast cancer, renal cell cancer, pancreatic
  cancer, Neuro endocrine cancer
• The prescribed dosage is 10mg should be taken as
  a single dose.In Brain or intracranial cancer
• The prescribed dosage of Rolimus  5mg is 4.5mg/m2
  orally as a single dose.In pediatric
• The usual pediatric dosage of Rolimus 5mg in
  brain or intracranial tumor is 4.5mg/m2 should be
  taken orally as a single dose. 

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PRECAUTIONS

• Lymphomas
• Increased exposure of skin cancers, patient may
  protect from UV lightSerious infections
• Patients receiving Rolimus 5mg have high risk of
  acquiring various infections related to bacteria,
  virus, and fungi. Anti-microbial agents are
  preferred for the suspected patients.

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SIDE EFFECTS

• Hypersensitivity reactions Lymphomas other
  malignancy Serious infections Kidney graft
  thrombosis Hepatic artery thrombosis
  Nephrotoxicity Hyperlipemia Angioedema
  Interstitial lung disease Thrombocytopenia
  Male infertility Proteinuria New commencement
  of diabetes .

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DRUG INTERACTION

•  Rolimus 5mg interaction with strong inhibitor
  of CYP3A4, or P-gp, leads to cause decreasing the
  efflux of Everolimus and increase the plasma
  concentration of Everolimus. Combination
  of Rolimus 5mg with verapamil leads to increasing
  the plasma concentration of Everolimus.
  Combination of Rolimus 5mg with Atorvastatin or
  pravastatin causes rhabdomyolysis, due to
  increasing concentration of lipid lowering
  agents. Rolimus 5mg combination with strong
  CYP3A4 inducers, causes increasing the exposure
  of Everolimus. Concomitant use of Rolimus
  5mg with cyclosporine causes increasing the AUC
  level of Everolimus frequently.

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CONTRAINDICATIONS

• Some anaphylactic reaction occurs, if patients
  are contraindicated to the components present in
  the Rolimus 5mg tablet.

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PREGNANCY

• Pregnancy category C Rolimus 5mg is needed only
  by the patients after knowing the benefits to the
  mother outweighs the risk to fetus.

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STORAGE

• Rolimus 5mg tablet should be kept at 25CKeep
  the tablet away from moisture, heat and
  lightDispense only in original container.

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MISSED DOSE

• If patient failed to take a single dose, patients
  must consult with medical practitioner and follow
  the instructions given by them. Or the missed
  dose should be avoiding and follow the regular
  dosing schedule.

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OVERDOSAGE

• The over dosage of Everolimus is rarely occur, in
  case of over dosage patient must be provide with
  supportive measures. The acute toxicity of
  Everolimus over dosage should be monitored.

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CONTACT US

• PHONE NO91-9940472902
• EMAILmillionhealthpharmaceuticals_at_gmail.com
• WEBSITE URLhttps//millionpharma.com/rolimus-5-mg
  .php