Zytiga 250mg (abiraterone acetate) Tablets-uses,side effects,price in india

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ZYTIGA 250 mg
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DESCRIPTION

•   Zytiga 250 mg is belongs to anti neoplastic
  drugs which will work by Diminish the androgen
  production in the body. Androgen is a male
  hormone which balances the cancer cell in
  prostate glands.
•   Normaly this tablet is taken by combination
  with prednisolone, a steroid which decreases the
  liability of side effects produced by
  Abiraterone.

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Mechanism of action

• Androgens are regulates the production of tumors
  in prostate. Zytiga is an anti androgen drugs,
  which causes to eradicate the enzyme
  17a-hydroxylase C 17, 20-lyase (CYP17), it is
  includes in androgen synthesis. Decrease the
  serum testosterone level. Diminished the tumor
  cell occurred.

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PHARMACOKINETICS

• ABSORPTION
•   Time to median plasma concentration of
  tablet Zytiga 250 mg tablet takes 12 hours.

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DISTRIBUTION

• Maximum bound to the human plasma protein like
  albumin and alpha-1 acid glycoprotein.

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METABOLISM

• The main two metabolites of Abiraterone in human
  plasma are Abiraterone sulphate and N-oxide
  Abiraterone sulphate.

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ELIMINATION

• Terminal half life of tablet Zytiga 250 mg is 12
  5 hours. The drug mainly excreted in 88 feces
  and 5 in urine.

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Zytiga 250mg

• Brand  Zytiga
• Ingredients  Abiraterone acetate
• Strength  Zytiga
• Manufactured  Janssen Pharmaceuticals
• Package  120 TabletsDOSAGE MANAGEMENT

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Dosage Management

• The usual dose of Zytiga is endorsed as 4
  tablets orally once daily The drug Zytiga given
  with 5mg prednisolone twice daily in empty
  stomach. Zytiga Tablets administrated on an empty
  stomach. No food should be consumed for at least
  2 hours before and at least 1 hour after the dose
  of ZytigaTablets is taken. Zytiga should be
  swallowed whole with water. Do not crush or chew
  the tablets.

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OVERDOSAGE

• Zytiga has no specific antitoxin, If overdose
  occurs stop the drug and provide general
  supportive measures such as monitoring
  arrhythmias and cardiac failure and assess liver
  function.

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DRUG INTERACTION

• Zytiga interaction with dextromethorphan will
  increases the Cmax and AUC of dextromethorphanZyti
  ga interaction with strong CYP3A inhibitors or
  inducers , use combination with caution because
  pharmacokinetics is not evaluated.

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PRECAUTION

• If patient having any allergy, severe liver
  problem, or pregnant, Zytiga tablet should be
  discontinued Do not take other medications, i.e
  prescription, over-the-counter, vitamins, herbal
  remedies, etc be sure to inform the doctors
  before the treatment. Aspirin do not
  administering and products containing aspirin
  till doctor particularly allow the drug.

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