A Comprehensive Guide to Therapeutic Drug Monitoring | Pyxus Pharmaceutical

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A Comprehensive Guide to Therapeutic Drug
Monitoring (TDM)
Therapeutic treatment has been used worldwide to
cure various diseases, alleviate pain in specific
body parts and even recover from injury. Pyxus
pharmaceuticals has Many essential tools that are
used in therapeutic treatments, such as radiation
therapy, drug therapy, nutrition therapy,
psychiatry, surgery, medical devices, stem-cell
therapies. Therapeutic treatment is renowned
across the globe for curing a wide range of
therapeutic areas, such as Migraine, Respiratory,
Headache, Neurodegenerative Conditions, Oncology,
and Movement Disorders. The demand for
therapeutic treatment is rising rapidly
worldwide. However, therapeutic drug monitoring
(TDM) must be done if you are taking therapeutic
treatment. In this blog, we will walk you
through what therapeutic drug monitoring (TDM)
is, its uses, its importance, guidelines, and
vital factors.
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What is Therapeutic Drug Monitoring (TDM)?
Therapeutic Drug Monitoring is a test for
measuring the concentration of a drug in a
patients bloodstream. It is done to ensure that
the concentration of medicine that the patient is
consuming is safe effective and not causing any
dangerous side effects. TDM helps healthcare
providers ensure that patients are consuming the
correct dosage of the prescribed drug. The drug
concentration is measured in blood and body
fluids like urine, sweat, and saliva. TDM helps
monitor individual drug concentration and help
doctors give effective quick diagnosis to
patients. The drug metabolism varies from patient
to patient. And TDM helps in individualizing the
required dosage in specific cases, thereby
improving the clinical effects of the drug
enhancing patient management.
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Importance Need of Therapeutic Drug Monitoring
As mentioned above, Therapeutic drug monitoring
(TDM) helps individualize patient-specific dosage
regimens (drug therapy). It also helps enhance
the drugs consumption efficacy and reduces the
toxicity of drugs for diagnostic purposes. Some
drugs have a wide co-efficient of pharmacokinetic
variation, which will have a significant
intra-patient variation between drug dosage its
effect. TDM is very beneficial helpful in these
situations. TDM helps healthcare providers
determine the correct dosage for their patients.
Once the determined dosage is prescribed, the
patient is tested regularly to ensure the
effectiveness of the drug concentration. Note
Side effects vary from patient to patient, and
TDM helps doctors give the proper medication to
the patients.
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Essential Information required for Therapeutic
Drug Monitoring

• Drug Pharmacokinetics
• Administration of the Drug dosage
• Clinical Condition of the patient
• Clinical History of the patient concerning past
  Therapeutic treatments
• Clinical Responses of the patient
• Sampling time
• The primary purpose of the TDM for determining
  efficacy and toxicity for diagnosis

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Process of Therapeutic Drug Monitoring

• The following is the process of TDM
• Administration of a pre-determined dose of a drug
• Collection Analysis of blood samples
• Pharmacokinetic Assessment of responses
• Evaluation of Clinical response
• Finalizing Dosage Regimen

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Guidelines for Therapeutic Drug Monitoring (TDM)

• Various organizations have laid down guidelines
  for TDM for different drug categories. Based on
  these specific drug guidelines and other sources,
  the following stages are critical for conducting
  interpreting Therapeutic Drug Monitoring (TDM)
  studies
• Documentation Legal Procedures involved in TDM
• Sample Collection Procedure
• Tests need to be conducted before conducting TDM
• Sample collection timing is decided depending on
  the half-life of the drug
• Sample concentrations
• Storage shipment of samples
• Monitoring of patients
• Laboratory measurements of drug concentration in
  blood
• Necessary action is required if abnormal results
  are observed
• Computing analytical data
• Interpretation of results recommendations
  accordingly

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Factors affecting Therapeutic Drug Monitoring
(TDM)

• Testing Methodology
• Sample collection time type
• Dosage Regimen
• Formation of active metabolites
• Age Effect
• Pharmacokinetics
• Pharmacodynamics

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Limitations of Therapeutic Drug Monitoring (TDM)

• Limited Infrastructure facilities in rural areas
• Variations in reports from lab to lab
• Cost of Therapeutic Drug Monitoring (TDM) study
• Lack of training quality assurance skills
• Invalid or Insufficient data for suggesting the
  target concentration range
• Variation or Lack of Accuracy Sensitivity of
  drug assay methods
• Active metabolites of a drug may contribute to
  therapeutic effect, but the active metabolites
  cannot be measured
• A limited number of drugs are suitable for TDM

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Analytical Techniques used to assay drugs in blood

• Many analytical techniques are used for
  quantifying the amount of drugs in blood or any
  other body fluid. The methods should be
• Able to detect small amounts
• Simple Straightforward to use
• Able to differentiate between compounds of
  similar structure drug its active metabolites
• Not having any interference with other drugs
  which are administered simultaneously.
• The following analytical techniques are used to
  assay drugs in blood and other body fluid
• Enzyme Immune Assay (EIA)
• RadioImmuno Assay (RIA)
• Spectrophotometry
• Chromatography

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Conclusion
After reading the blog, you will have a
comprehensive understanding of Therapeutic Drug
Monitoring (TDM), its importance need,
essential information required, process,
guidelines, factors, limitations, and analytical
techniques. Pyxus Pharmaceuticals is a leading
Therapeutic Treatment Products Manufacturer. If
you have questions or want more information,
contact us, and one of our medical
representatives will contact you. We are
available via call at 91-9824728969 or email at
ahemad_at_pyxuspharmaceuticals.com. Check out our
wide range of pharma drugs in our product section.
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