MR Imaging of Atherosclerosis in Human Carotid Arteries

1
MR Imaging of Atherosclerosis in Human Carotid
Arteries
Chun Yuan, Ph.D. Thomas S. Hatsukami, M.D.
University of Washington
2
Carotid MRI Hardware

• Phased array coils
• Designed / built in-house
• Flexible
• Bi-lateral
• Significant SNR improvement
• Head holder
• Restricts motion
• Consistent positioning
• Patient comfort

- Hayes, et al., JMRI 6109-112, 1996.
3
Multiple Contrast Imaging
T2
PD
Oblique View
PD,T2 Shared Echo FSE T1 Double IR FSE
TOF
T1
Yuan C, et al. Radiology 2001 221295-299.
4
CE MRI of Carotid Atherosclerosis
Neovasculature and Necrotic Core
10x

Mallorys Trichrome
Pre-Pre Contrast-T1W

25X
Inset (90 rotation)
Post Contrast
Yuan C, et al. JMRI, 1562-67, 2002
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MRI of Carotid AtherosclerosisReproducibility335
S6
t1
t t1 0
t2
1
t t2 1
t0 t1
t1
t2
t0 t1
DIR T1W T1-T2 2 weeks
t1
t2
Kang et al. MRM, 44968-972, 2000
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MRI of Atherosclerosis Appearance of
Intraplaque Hemorrhage
10X
?
Movats Trichrome
Yuan C, et al. Circulation, 1042051-2056, 2001.
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MRI of Atherosclerosis Appearance of Thick
Fibrous Cap
ECA
ECA
ICA
ICA
10X
Ca
Ca
ECA
TOF
PDW
ICA
Ca
ECA
ECA
ICA
ICA
Ca
Ca
T2W
T1W
Yuan C, et al. Circulation, 105181-185 2002.