UC Davis Clinical and Translational Science Center

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UC Davis Clinical and Translational Science Center

• Ralph Green, MD PhD
• (With thanks to Lars Berglund, MD PhD) PI
• Professor of Medicine
• Associate Dean, Clinical/Translational Research

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Role of Pathology in CTSA Grants Being There

• Ralph Green, MD PhD
• University of California Davis

If you water it, it will grow Chauncy Gardener,
1979
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UC Davis CTSA
Ralph Green, MD PhD University of California
Davis
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Infectious Diseases
VascularBiology
UC Davis School of Medicine Strategic Plan 2005
Cancer
Neuroscience
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GCRC Core Lab
Mouse Biology
Cell Trafficking
Informatics
Immunology
Cancer
Infectious Diseases
Nutritional Assessment Lab
Department of Pathology and Laboratory
MedicineAffinity Groups and Research Activities
Vascular Biology
Microarray
Optical Biology
Stem Cells
Neuroscience
HBSR Tissue Repository
Proteomics Multiplex Technology
Histology EM
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A Transforming Approach NIH Clinical and
Translational Science Awards (CTSA)

• Substantial change in NIH practice focus on
  bridging translational gaps and catalyzing change
  Team science
• Increase application pace for basic science
  innovations into practice health care costs in
  the future astronomical
• Prevention rather than treatment of disease
• CTSAs are experiments different pathways
  possible depending on the institution

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UC Davis CTSC 3 themes

• Collaborative campus existing
  trans-school/college collaborations,
  transdepartmental graduate groups
• Outreach and community telecommunications,
  community-based activities, established primary
  care network
• Testing ground in place GCRC, K30, CRISP

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Strengths in grant proposal and going forward

• Integration between programs (whole bigger than
  parts)
• Alignment with SOM and UCD strategic goals
• Building on existing resources and initiatives as
  models test already done (CRISP, Telemedicine
  program, Culture with graduate groups,
  Translational program Cancer Center LLNL,
  primate center, CCM,WHNRC,MIND,etc)
• Consistently seeking a broad-based participation
  Partnership based on history
• Team science-based education in place

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CRISP Refinement of GCRC concept

• Co-localization of GCRC service functions with
  CRISP bringing GCRC resources to a wider user
  group
• Maintaining and strengthening core GCRC unit
• Co-localization with IRB demystifies close
  relationship between IRB/GCRC reviews, common
  VA/UCD IRB review
• Inclusiveness CRISP/GCRC is a resource for all

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Community Engagement Program Key Partners

• Center for Reducing Health Disparities
  diversity and lay community
• Center for Health Services Research in Primary
  Care practitioner network
• Telemedicine/Telepathology/Teletechnology
  integration of novel technology advances in
  research bridging to practitioners and rural
  settings
• Community-based and student-run clinics
• Existing community-based research programs
  (cancer, autism)

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Informatics Program

• Support for CTSC operations, local and national
• Assistance with institutional informatics
  planning
• Communication - CHT Telemedicine services
• Clinical data collection - EMR
• Automation of clinical trials - Velos
• Data sharing - data standards and terminology
• Demonstration project - CTSC-EMR research
  collaboration
• CTSC Collaboration - UCSF

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CTSC Informatics - future

• Improve EMR data quality
• Develop research potential of EMR and
  Telemedicine - partnership
• CTSC Research Portal unifying concept
• CTSC Data Repository - translational data
  environment
• Informatics and data management consulting
  services
• Information Science Research
• Build on experiences from national consortium

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CTSC A Partnership program

• CTSC grant - substantial institutional commitment
• NIH Grantees represent mature institutions
  with developed infrastructure
• CTSC needs to resonate with complementary
  institutional infrastructure (CTSC substrates)
  for full potential
• Large institutions have a wide spectrum of CTSC
  substrates in place rapid implementation
• UC Davis - model for medium-sized institutions to
  develop CTSC substrates complementing
  existing infrastructure

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The UCD CTSC Research Incubator a
Transformative catalyst
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UC Davis CTSC recipe for success

• Participation Everyones center and everyones
  business
• Partnership Public, Investigators, Trainees,
  National consortia, NIH
• Communication inoculation of program
• Responsibility live up to the NIH mandate
• National recognition model for medium-sized
  institutions
• Added value the whole more than parts

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UC Davis CTSC - challenges

• Efficient communication of CTSC concept
  creating a Roadmap for the Roadmap
• Being too diffuse being all things to all
  people
• Strategic identification of gaps where addition
  of CTSC resources has greatest potential for
  institutional growth
• Finding an optimal interface between CTSC and
  infrastructure resources resonance in harmony
• Engineer CTSC implementation in step with
  institutional growth

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Enhance the culture
Information Education Opportunities Engagement Lin
king
Medical Center, Sacramento
Davis Campus
Affiliated Partner Sites
Telemedicine System
PCN and Regional Care System
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Role of Pathology in CTSA Grants Being There

• Ralph Green, MD PhD
• University of California Davis

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Education and Training a continuous model