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Challenges of Fragility Fracture Treatment

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Title: Challenges of Fragility Fracture Treatment


1
Challenges of Fragility Fracture Treatment
  • David Marsh
  • Institute of Orthopaedics
  • University College of London
  • Royal National Orthopaedic Hospital
  • Stanmore
  • England

2
Optimal care of fragility fracture
patientGoals, challenges and solutions
Acute medical management
Keep the patient alive
Fix the fracture
Surgical challenges
Keep patient mobile
Multidisciplinary rehab
Keep patient from returning to your fracture unit
Osteoporosis management and secondary prevention
Quality control of process
3
Optimal care of fragility fracture
patientGoals, challenges and solutions
Acute medical management
Keep the patient alive
4
Complexity of elderly patients
  • Mean age hip fracture 80 yrs
  • Comorbidities (median ASA 3)
  • Murmurs
  • Renal - Dialysis
  • COPD - home O2
  • Diabetes
  • Delirium / dementia
  • Pseudo-obstruction
  • Alcohol abuse
  • Impaired metabolic response to injury
  • Hyponatraemia
  • Management problems
  • Consent
  • Theatre scheduling
  • Discharge planning
  • Polypharmacy
  • Warfarin
  • Plavix
  • Neurotropics

5
Acute medical management
  • Slow but steady rise in age of patients
    presenting with fragility fractures. Many have
    multiple co-morbidities
  • Difficult judgement balance between medical
    optimisation and prompt surgery
  • Inexperienced surgical trainees not the best
    people to look after such people and prepare them
    for surgery
  • Ideal solution is close supervision by senior
    physicians having expertise with elderly patients
  • pre- and peri-operatively, not just for
    rehabilitation

6
Senior medical backup desired
  • Can come from different specialists, depending on
    health care system
  • Anaesthesia - Geriatrics
  • Cardiology - Respiratory
    medicine
  • Internal medicine
  • Orthogeriatrics may play larger role in future

7
The pay-off from orthogeriatric care in the acute
phase
  • Superior medical care
  • Optimal scheduling of fracture surgery
  • Better communication with patients and relatives
  • A leader for the multidisciplinary team

Quality service is cheaper in the end
8
Alternative models for orthogeriatric care
  • Orthopaedic doctors and nurses supported by
    visiting medical specialist
  • Nurse specialists on fracture wards, supervised
    by geriatricians
  • Geriatricians employed on fracture wards
  • Elderly fracture patients admitted to geriatric
    wards

9
Optimal care of fragility fracture
patientGoals, challenges and solutions
Acute medical management
Keep the patient alive
Fix the fracture
Surgical challenges
10
Main surgical challenges
  • Impaired ability of osteoporotic bone to hold
    screws
  • Crushing of cancellous bone with creation of
    voids after fracture reduction

Altogether, these factors lead to a higher risk
of failure at the implant-bone interface before
healing achieved
11
Some surgical solutions
  • Avoid the problem with arthroplasty
  • Allow early mobilisation
  • Improve implants for osteoporotic bone
  • Fixed angle locking plates
  • Hydroxyapatite coating of screws
  • Use IM nail instead of onlay devices for
    diaphyseal fractures
  • Fill voids with cement

12
Proven arthroplasties relevant to challenging
osteoporotic fractures
Hip
Shoulder
Knee
Elbow
Images courtesy of John Keating
13
Arthroplasty as an alternative to fixation Hip
  • Hemiarthroplasty established and widely preferred
    to ORIF in displaced subcapital fractures
  • But still controversial
  • Total arthroplasty increasing
  • Keating et al. J Bone Joint Surg 2006.
    88A249-60 THR greater initial cost but
    cheaper in the long run with better function.

14
Arthroplasty as an alternative to fixation Knee
  • Technically demanding
  • Revision components often needed
  • Complications common

15
Arthroplasty as an alternative to fixation
Shoulder
  • Useful particularly for 3-part and 4-part
    fractures and fracture dislocations
  • Early treatment best
  • Good pain relief, but poor movement and function
  • Soft tissues influence outcome

16
Arthroplasty as an alternative to fixation Elbow
  • C3 distal humerus, below condyles, radial head
  • Good results in small, uncontrolled series
  • Probably better than ORIF
  • More studies needed

17
Locking plates
  • Screw head threaded engages with hole in plate
  • Single mechanical unit internal fixator
  • No compressive force on periosteum

F. 82yrs
1 MONTH
POST OP
1 YEAR
18
Fixed angle plate for shoulder
  • Pullout from head less likely with diverging,
    fixed-angle screws
  • Increases scope for ORIF as opposed to
    hemiarthroplasty

Plecko and Kraus, Oper Orthop Traumatol 2005
1725-50
19
Fixation augmentation with hydroxyapatite-coated
screws
Magyar G et al, J Bone Joint Surg Br.
199779487-9 Moroni A et al, Clin. Orthop.
1998346171-77 Moroni A et al, Clin Orthop.
2001388209-17 Moroni A et al, J. Bone Joint
Surg. Am. 200183-A(5)717-21 Sandèn B al, J.
Bone Joint Surg. Br. 200284(3)387-91 Caja VL et
al, J. Bone Joint Surg. Am. 200385-A(8)1527-31 M
oroni A et al, Clin. Orthop. 2004 42587-92
Moroni A et al, J. Bone Joint Surg. Am. 2005
83-A(5)717-21
20
Improved osseointegration with HA-coated screws
HA-COATED SCREW
STANDARD SCREW
A. Moroni et al. J. Orthop. Trauma 2002
16257-63
21
HA-coated dynamic hip screw
  • Study Aim
  • To compare DHS fixed with standard vs HA-coated
    AO/ASIF screws in osteoporotic patients with
    trochanteric fractures

Standard
HA-coated
Moroni et al. Clin Orthop Relat Res. 2004
42587-92
22
Study population
HA-coated Screws
Standard Screws
  • No. of patients 60 60
  • Age (yrs) 81 8 81 6
  • BMD 538 105 568 111
  • AO A1 42 48
  • AO A2 58 52

Moroni et al. Clin Orthop Relat Res. 2004
42587-92
ns
23
Standard vs HA-coated screwsFemoral neck-shaft
angle
Standard Screws
HA-Coated Screws
Angle (degrees)
p0.008
POST-OP
6 MONTHS
Moroni et al. Clin Orthop Relat Res. 2004
42587-92
24
Standard vs HA-coated screws
Moroni et al. Clin Orthop Relat Res. 2004
42587-92
25
Standard Screw Complications
26
Possible solution HA-coated screw
  • Note bone growth around the tip of the screws
    beyond the exit cortex

27
HA-coated screws Wrist external fixator
  • Caveat HA-Coated Pins can be difficult to
    remove from cortical bone

28
Void filling with bone substitutes
  • Deformation and loss of support by crushing of
    cancellous bone. Relevant in metaphyseal
    long-bone fractures and spine
  • Inert materials, such as PMMA cement, vs.
    potentially integrating scaffold, i.e. graft
  • Autologous bone graft limited. Allograft carries
    risk of disease transmission. Artificial
    substitute desirable
  • Matrix (scaffold) plus or minus inductive
    molecules or cells

29
Void filling with bone substitutes
30
Calcium phosphate cement augmentation
31
Void Filling / Support of trabecular bone in
metaphyseal fractures
  • Maintains radial length, avoids re-operation and
    increases grip strength.

Constantz et al. Science 1995 2671796-99
32
Vertebral fragility fracture impairs quality of
life more than we think
0
  • Predicted prevalence of vertebral fractures in
    the E.U.
  • 2000 23.7 million
  • 2050 37.3 million

-0.05
-0.1
-0.15
-0.2
-0.25
-0.3
-0.35
Hip
Wrist
Vertebral
Shoulder
Loss of utilities, over 1 year calculated from
EQ5D
Kanis et al.Osteoporos Int 2001 12417-427
33
Vertebroplasty and kyphoplasty
  • Filling void in crushed vertebral body with PMMA
  • Patient prone transpedicular injection of
    cement
  • Vertebroplasty high pressure injection good
    pain relief
  • Kyphoplasty pre-insertion of balloon to create
    a void for low pressure injection aiming for
    height restoration

34
Balloon kyphoplasty Can you uncrush a bone?
35
Kyphoplasty
36
Efficacy of vertebroplasty and kyphoplasty
  • Similar efficacy in pain relief, better than
    conservative treatment
  • Kyphoplasty fewer adverse events (leakage, VTE)
  • Stronger evidence for functional and QOL
    Improvement
  • Most experience to date with late, failed
    conservative cases
  • Sagittal correction with kyphoplasty may be
    better if performed earlier

Taylor et al. Spine. 2006 312747-2755
37
Osteoporosis therapy and fracture healing
  • Theoretical concern
  • Reduction of bone turnover by anti-resorptive
    drugs may inhibit fracture healing

38
Anti-resorptive drugs and fracture healing
  • Large clinical trials of anti-resorptive agents
  • 2000 - 7000 patients over 3 years
  • no adverse events related to fracture healing
  • Animal studies of fracture healing
  • delay in remodelling of callus
  • no positive effect on restoration of mechanical
    strength
  • Bisphosphonate may delay loosening of implants
  • No clinical trials in humans directly testing
    effect of anti-resorptive therapy on fracture
    healing

39
Raloxifene, estrogen and alendronate affect the
processes of fracture repair differently in
ovariectomized rats
  • OVX vs sham-op in 3-month-old rats
  • Closed, nailed femoral shaft fracture
  • OVX alone, or with E, raloxifene (RAL), or
    alendronate (ALN)
  • X-ray, QCT, biomechanical testing, histology
  • At 6 and 16 weeks

Cao et al. J Bone Miner Res 2002 172237-46
40
Fracture healing properties vs sham control
  • Alendronate delayed callus remodelling (lower
    ratio of lamellar to woven bone), but larger
    callus was stronger

Cao et al. J Bone Miner Res 2002 172237-46
41
Balance of risks
Theoretical worries about importance of
remodelling in fracture repair
Definite increase in fracture incidence if
secondary prevention not initiated
But caution before treating with rigid internal
fixation, requiring osteoclast-led remodelling
42
Anabolic therapy would remove this worry -
preclinical evidence with PTH
  • Paradoxical effect of PTH when given
    intermittently anabolic for bone. Confirmed in
    clinical trials of osteoporosis treatment.
  • Several groups show enhanced fracture healing in
    animal models
  • Andreassen 1999, 2001, 2004. Komatsubara 2005.
    Alkhiary 2005

Alkhiary et al J Bone Joint Surg Am. 2005
87A731-41
43
Systemic bisphosphonate therapy may enhance
HA-coated screw fixation
  • Prospective randomised study in externally-fixed
    intertrochanteric fractures
  • Women aged 65 with low BMD and no prior BP
    therapy
  • Intertrochanteric fracture (AO/OTA type A1 or A2)
  • HA-coated pins in both groups
  • Group A oral dose of 70 mg of Alendronate per
    week
  • Group B no alendronate
  • Screw insertion/extraction torque measured at
    insertion/removal

Moroni et al. J Bone Joint Surg Am. 2005 87
Suppl 242-51
44
External fixation device
Pre-op
Post-op
XX months?
All the devices used in this study are FDA
approved Slides provided by A. Moroni, Bologna,
Italy
45
Baseline characteristics
Alendronate (n8)
Control (n8)
82 8 543 87 4 3 1
78 6 yrs 527 23 5 2 1
  • Age (years)
  • BMD
  • Quality of reduction
  • Good
  • Acceptable
  • Poor

Baumgaertner et al. J Bone Joint Surg Am. 1995
771058-64
46
Screw extraction torque higher for cancellous
bone in ALN vs control at 3 months
Cancellous bone (femoral head)
Plt0.001
Cortical bone (femoral shaft)
5000
ns
4000
3000
2000
1000
0
Moroni et al. J Bone Joint Surg Am. 2005 87
Suppl 242-51

47
Optimal care of fragility fracture
patientGoals, challenges and solutions
Acute medical management
Keep the patient alive
Fix the fracture
Surgical challenges
Keep patient mobile
Multidisciplinary rehab
Keep patient from returning to your fracture unit
Osteoporosis management and secondary prevention
Quality control of process
48
Multidisciplinary rehabilitation
  • Goals
  • Restore quality of life through mobility
  • Prevent future fractures by preventing falls
  • Should be led by the appropriate
    rehabilitationists
  • Discharge planning integration of medical and
    social services needs to start immediately
  • Nutrition a vital element
  • High protein diet improves recovery
  • Vit D insufficiency very common, readily treated

Duncan et al. Age Ageing 2006 35148-53
49
Secondary prevention
  • One of the strongest predictors of fragility
    fracture is having had one already
  • Bone strength
  • Tendency to fall
  • Our response to a fragility fracture must include
    a determined attempt to prevent another one
  • Need not require orthopaedic surgeons to
    treat,or even remember to refer
  • Needs a system that achieves this automatically

50
Systems for secondary prevention
  • Most reliable when based on nurse specialists,
    e.g.
  • Fracture liaison nurses in fracture clinic
  • Fragility fracture nurse coordinators for
    inpatients
  • Many different models possible
  • Key is that responsibility is clear
  • Needs local agreement on referral mechanisms
    between fracture service, osteoporosis service
    and falls service
  • Vital to involve GPs because prevention has to be
    life-long
  • Essential to empower the patient by thorough
    education

51
Hip Fracture Audit
  • Experience (e.g. in Scotland) has shown that
    ongoing, real-time audit, in conjunction with
    evidence-based guidelines, can change practice in
    a non-threatening way
  • Preferably national or regional, so that
    performance can be fed back in context of peers
  • Records process and outcome to one year
  • Owned and controlled by the professions
  • Raises the profile of osteoporosis and fragility
    fracture work with the managers and commissioners

52
Summary
  • Fragility fractures present a serious challenge
    to fracture services, both because of the high
    volume and because of their medical, surgical
    and logistic complexity
  • Multidisciplinary working is the key to success
    and alliance between orthopaedics and geriatrics
    is particularly valuable
  • Surgical technique must be adapted to take
    account of complications of fracture repair and
    healing in the elderly
  • It is absolutely necessary to deliver secondary
    prevention reliably to every patient
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