caBIG and TBPT Activities

1
caBIG TBPT Strategic Plan Summary Short term
and long term goals for the Tissue Banks and
Pathology Tools Workspace
Greg Eley April 12, 2006
2
Strategic Goals Purpose

• Provide direction and vision for the TBPT WS now
  and over the next 5 years
• Inform the caBIG Strategic Planning Workspace
• Drive funding decisions for the current year
• Roadmap for participation in TBPT
• Provide opportunities for rational contributions
  by the community

3
Categories of TBPT Strategic Goals

• Primary Development Projects
• Integrated Tissue Banking Suite
• New Tool Development
• Cross Workspace Collaboration
• Outreach

4
Primary Development Projects

• caTISSUE Core
• caTISSUE CAE
• caTIES
• Short term goals
• Stable release with Adoption by multiple
  institutions
• Near term goals
• Enhance functionality and usability
• Test interoperability of the separate components
• Grid enable all three components
• Long term goals
• Expand adoption community

5
Integration of Tissue Banks Applications

• Develop an integrated suite to hang components on
• Integrated data model
• Streamlined system that reduces component
  redundancy
• Single user interface for all components
• Leverage caGRID architecture for common query
  mechanism
• Super-adoption
• All three applications adopted at multiple
  institutions
• Drive requirements and validation of systems
  integration development

6
New Tool Development

• Whole Slide Imaging Tools
• Help develop whole slide imaging standards
• Create imaging algorithms for structure
  segmentation and analysis
• Integrate with caTISSUE CAE
• Tissue Microarray (TMA)
• Develop TMA component for integration into ITBS
  (caTMA?)
• Help develop TMA standards
• Develop TMA Object Model for integration in
  caTISSUE EAM
• TMA analysis algorithms
• House Keeping Components
• Batch processing of samples / barcoding
• Shipping / Receiving module
• Billing module
• All to be pluggable into the integrated tissue
  banking system

7
Cross Workspace Collaboration

• Exchange information with CTMS tools
• Integrate TBOM with CTOM
• Link to CTMS Laboratory interface
• Link to CTMS Study Protocol system
• Link to Patient Registry
• Exchange experimental data with ICR
• Link EAM with caARRAY (others)
• Leverage genomic and proteomic standards for TMA
  representation/analysis
• Consumable by caIntegrator ?
• ?
• Cooperation with ARCH and VCDE WSs
• Validate caGRID and CDE architectures via virtual
  tissue repository
• Grid-enable all TBPT apps
• Validate grid security model through data sharing
• ?

8
Outreach

• Participation in TBPT WS by wider audience
• Inclusion of non-funded participants in all
  activities
• Work with industry partners as appropriate
• Develop community communication tools/processes
• Harmonization with additional NCI initiatives
• Work with patient advocate community to
  facilitate community education and involvement
• Support NCI international biobank initiatives
• Collaboration with other related programs to
  integrate information and surface best
  practices to be shared
• National Biospecimen Network (NBN)
• Early Detection Research Network (EDRN)
• Shared Pathology Informatics Network (SPIN)
• Cooperative Group Banking efforts (Coop-Groups)
• Proof of Concept Federated Biospecimen Network
• Leverage NBN activities and community as a proof
  of concept for collaborative studies