The Use of Bioinformatics and Functional Genomics in the Analysis of Complex Diseases.

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Clinical Bioinformatics the need for CBAS and
SCBC in Applied Sciences?

• Dr James Mah
• MBBS(Lon), BSc(Hons,Lon).
• Chair, CBAS 2009 Singapore
• Email tutorsgsg_at_yahoo.com.sg

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Clinical Bioinformatics

• The use of informatics tools and techniques to
  study and analyse biomedical and genetic data
• Involves the development of new tools and
  algorithms to solve biomedical issues
• Involves new discovery of biomedical knowledge
  and know how
• Covers and overlaps with many disciplines and
  fields in applied sciences
• Clinical/biomedical example..

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CLINICAL BIOINFORMATICS

• New methods to rapidly and conveniently screen
  any genetic variant
• -probability of association with disease risk
• -probability of treatment outcome

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The Clinical Bioinformatics Cycle
Egs
Clinical Bioinformatics

(NEW!)
Results?
DISEASE
Cure
HEALTH
Prevention
DRUG (outcome)
CANCER RISK PREDICTION
DEATH
Personalised Medicine
(Survival outcome)
TREATMENT OUTCOMES eg TOXICITY
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CASE STUDY 1 DRUG TREATMENT OUTCOME MODEL
Gene VKORC1(Vitamin K epoxide reductase complex
1) story
a)Study in European-American population (Rieder
et al 2005)
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b)Study in Asian population (Lee SC et al 2006)
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CASE STUDY 2 SURVIVAL OUTCOME MODEL
THE GEMCITABINE NON-SMALL CELL LUNG CANCER STORY
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POTENTIAL USES OF NEW BIOMEDICAL IMAGING TOOLS

• Screening
• For suspicious lesions
• -population screening
• Eg for breast cancer detection
• -epidemiological studies
• -risk stratification
• cancer prevention, treatment programmes

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1st Clinical Bioinformatics Symposium on Applied
Sciences (CBAS) 2009

• Promote awareness of Clinical Bioinformatics and
  its applications in biomedical sciences and
  healthcare
• Sharing of views by renowned speakers invited to
  tackle complex and diverse topics in Clinical
  Bioinformatics
• Networking session and SCBC to allow participants
  to showcase their work to foster
  inter-disciplinary collaborations
• Help foster the Clinical Bioinformatics Cycle

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TIME   CBAS PROGRAMME SCHEDULE
830 AM   Registration
900 AM   CBAS Opening by Chair, JAMES MAH TITLEClinical Bioinformatics the need for CBAS and SCBS in Applied Sciences?
920 AM   Keynote Plenary WONG TIEN YIN
    TITLE Translational research and Bioinformatics in Singapore advances, breakthroughs and initiatives- a clinical prospective
1015 AM   Special QA
     
1030 AM   Morning Tea Break
1100 AM   Plenary 2 SU YI
    TITLE Biomedical modelling with clinical applications
1130 AM   First Singapore Clinical Bioinformatics Consortium Meeting
    First Singapore Clinical Bioinformatics Consortium Meeting
1230 PM   Lunch Break
120 PM 130 PM   Introduction  to Afternoon session by Chair, JAMES MAH Plenary 3WAYNE MITCHELL
    TITLE Translational research and drug discoverycan bioinformatics help?
200 PM   Plenary 4 LEE HWEE KUAN
    TITLE Computer vision and pattern discovery for bioimages An emerging field in bioinformatics
230 PM   Plenary 5 CAROLINE LEE
    TITLE Pharmacogenomics and personalized medicine- advances and possible roles of bioinformatics
300 PM   Sponsor Talk Chris Molloy, VP Corporate Development, ID Business Solutions
    TITLE Translational Medicine and Biomarker discovery an informatics issue
330 PM   Afternoon Tea Break
400 PM   Plenary 6 LUN KWOK CHAN
    TITLE Medical Informatics past, present and future
430 PM   QA/Networking/Collaboration presentations II
520 PM   Plenary panel discussion Clinical BioinformaticsPresent  and Future
545 PM   CBAS Closing remarks
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The Singapore Clinical Bioinformatics Consortium
(SCBC)

• Part of CBAS to continue inertia and initiative
• Seek representatives from each institution to
  strengthen ties and build up strong links for
  collaboration in the field of Clinical
  Bioinformatics
• Potential aims would be to initiate key or core
  project areas with potential for development both
  locally as well as regionally

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The Singapore Clinical Bioinformatics Consortium
(SCBC)

• Tie-ups with industry and pharmaceutical
  companies are also encouraged
• Invitation to be part of this exciting Consortium
  as committee members to spearhead and drive new
  clinical bioinformatics projects both regionally
  and internationally

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The Singapore Clinical Bioinformatics Consortium
(SCBC)

• Invitation for contribution in but not limited
  to
• -Biomedical Imaging
• -Translational Research
• Eg Bench-to-bedside or personalized medicine
• -Genomics
• Eg functional annotation of genetic variants with
  respect to complex/clinical diseases
• -Drug discovery
• Eg novel drug target identification and discovery

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Acknowledgements

• Dr Victor Tong and InCoB 2009 committee
• ASTAR
• All our sponsors and dedicated supporters
• Distinguished speakers
• Dedicated CBAS 2009 organising committee
• Tze Hau, Meng Ling, Luke, Winnie, all volunteers
• Delegates and attendees
• All those indirectly or directly made this event
  possible