Longitudinal Nationwide Antimicrobial Susceptibility Surveillance in Ocular Isolates: Results from Ocular TRUST 2

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Longitudinal Nationwide Antimicrobial
Susceptibility Surveillance in Ocular
IsolatesResults from Ocular TRUST 2
Penny A. Asbell, MD1 Daniel F. Sahm, MD2 1Mount
Sinai School of Medicine, New York, NY
2Eurofins Medinet, Inc, Anti-Infective Services,
Herndon, VA
Financial Disclosure Dr. Asbell has served as a
consultant to Inspire Pharmaceuticals and has
received lecture fees from Alcon Laboratories,
Allergan Pharmaceuticals, Santen Pharmaceutical,
Inspire Pharmaceuticals, and Vistakon
Pharmaceuticals. Dr. Sahm is a full-time employee
of Eurofins Medinet, Inc., Anti-Infective
Services and has received lecture fees from
Vistakon Pharmaceuticals.
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Ocular TRUST Nationwide Antimicrobial
Susceptibility Surveillance Program

• Ocular isolates only
• Initiated in 2005
• Largest surveillance program with centralized in
  vitro susceptibility testing
• Annual surveys providing longitudinal data

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Ocular TRUST 2 (2006-2007)
Susceptibility testing specific to ocular isolates Susceptibility testing specific to ocular isolates
Pathogens Antimicrobials
S. aureus Ciprofloxacin
S. epidermidis Gatifloxacin
S. pneumoniae Levofloxacin
H. influenzae Moxifloxacin
Azithromycin
Penicillin
Polymyxin B
Tobramycin
Trimethoprim
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Ocular TRUST Participating Sites
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Ocular TRUST 2 S. aureus Susceptibility
MSSA (N71)
MRSA (N84)
Susceptible
18
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Ocular TRUST 2 Coagulase-Negative Staphylococci
Susceptibility
Methicillin-susceptible (N40)
Methicillin-resistant (N52)
44
Susceptible
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Ocular TRUST 2 S. pneumoniae and H. influenzae
Susceptibility
S. pneumoniae (N198)
H. influenzae (N144)
100
Susceptible
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Ocular TRUST 2 Overview

• Methicillin resistance in staphylococci marker
  for multi-drug resistance
• Fluoroquinolones most consistently active agents
  across ocular pathogens
• Fluoroquinolone susceptibility profile
• Gatifloxacin Levofloxacin Moxifloxacin
• Modest diminution in S. pneumoniaesusceptibility
  to ciprofloxacin
• Polymixin B and penicillin most limited activity