Evaluation of Response to Induction-Chemotherapy in Correlation to p53 Genotype in NSCLC stage III; Phase II Study

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Evaluation of Response to Induction-Chemotherapyi
n Correlation to p53 Genotype in NSCLC stage III
Phase II Study
P53 analysis
OP
Response
P53 analysis
Failure
OP
Purpose First prospective evaluation of the
impact of the p53 genotype for response to
different CTs
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Evaluation of response to induction - CT in
correlation to p53 genotype in NSCLC stage III
phase II studyShort title p53 tailored
induction therapy

• Currently open, accademical study
• 7 investigational centers in Austria
• 25 patients accrued, 37 additional needed
• Intended by www.p53.at

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Evaluation of response to induction-CT in
correlation to p53 genotype in NSCLC stage III
phase II study

• Inclusion
• NSCLC Stage IIIA or IIIB
• No prior NSCLC therapy
• Age 18-70

• Exclusion
• Recent CT with investigational drug
• Second primary CA
• Concurrent other tumor therapy