Engineering, Biology, and NSF March 29, 2004 ASEE 2004 Engineering Deans Institute Bruce Hamilton Di

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Engineering, Biology, and NSFMarch 29,
2004ASEE 2004 Engineering Deans Institute
Bruce HamiltonDivision Director,
Bioengineering and Environmental Systems
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A quick glance at the past--At NSF,Engineering
Has Been Involved with Biology For Decades
ExampleEarly 1970sNSFs Enzyme Engineering
Program
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A quick glance at the pastNSFs Enzyme
Engineering Program (1970s)One Example
ProjectMIT Project onPreparative-Scale
Enzymatic Synthesis of Gramicidin Sand Enzymatic
Regeneration ofAdenosine Triphosphate (ATP)
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MIT Project onPreparative-Scale Enzymatic
Synthesis of Gramicidin Sand Enzymatic
Regeneration of ATP (1970s) Disciplines on
Team Example Key Faculty Engineering Dan
Wang Biology Arnold Demain Chemistry George
Whitesides Weekly group meetings of faculty
from all three disciplines with students from all
three disciplines (undergraduate, graduate,
post-doc)
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Engineering, Biology, and NSF--Many Other
Examples, From Both Before and After 1970s Some
Are
- Tissue Engineering
- Mammalian Cell Engineering
- The Artificial Retina
- Metabolic Engineering
- Bioproducts from Cellulose
- Biomaterials Engineering
- Phytoremediation
- Therapeutic Protein Engineering

• - Gene Therapy Engineering

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An observation on the past--At NSF, looking
back,the involvement of Engineering with
Biology has Focused on Engineering Specialties
Biochemical Engineering Biomedical Engineering
Bioenvironmental Engineering
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Currently, Change!
At NSF now, the involvement of Engineering with
Biology has become much more pervasive,going
well beyond Engineering Specialties
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All 6 NSF ENG DivisionsSupport Biology-Oriented
Awards

• BES All aspects of biology and engineering

CMS Biomechanical Eng (e.g., bone biomaterials)
CTS Biotransport Eng (e.g., blood flow fluid
dynamics)
DMII Engineering Health Care Delivery
ECS Many aspects of biology and engineering
(e.g., biomedical imaging)
EEC Centers, Dept. Reform biology and
engineering
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NSF CISE Directorate AlsoSupports
Engineering/Biology-Oriented Awards(Computer and
Information Science and Engineering)

• Example--
• ITR 0205741 Simulation-Based Medical Planning
  for Cardiovascular Disease
• PI Charles Taylor
• Department of Bioengineering
• Stanford University
• 3.7 million over 5 years

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Current Pervasiveness of Biology in Engineering

• Pillars Model for the Foundations of
  Engineering Education
• Older Pillars Model Newer Pillars Model
• - Mathematics - Mathematics
• - Physics - Physics
• - Chemistry - Chemistry
• - Biology

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Biology in EngineeringImplications for Change
inEngineering Education

• Example NSF Programs

- Department-Level Reform (ENG EHR)
- IGERT (cross-NSF)
- BBSI (NSF and NIH)
- CCLI (DUE)
- VaNTH ERC (EEC BES)
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Department-Level Reform Grants

• Example (undergraduate Engineering/Biology)
• NSF Award 0343283
• Establishing a Cross-Disciplinary Bioengineering
  Program with a Technical Entrepreneurship Focus
• PI Mohamed El-Aasser
• Lehigh University
• 1.4 million over 3 years

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IGERT Grants

• Example (graduate Engineering/Biology)
• NSF 0114264
• Program in Cellular Engineering
• PI Jennifer West
• Rice University
• 2.5 million over 5 years

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BBSI Grants

• Example (undergrad seniors 1st year grad
  students)
• BioMEMS Summer Bioengineering Institute at New
  Jersey Institute of Technology (NJIT)
• PI William Hunter
• NJIT
• 720K over 4 years

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CCLI Grants

• Example (undergraduate course)
• NSF 0231313
• Development of Educational Materials that
  Strengthen Students Problem-Solving Skills for a
  Bioengineering Fundamentals Course
• PI Ann Saterbak
• Rice University
• 75K over 2 years

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VaNTH ERC

• VaNTH ERC for Bioengineering Educational
  Technologies
• VaNTH Vanderbilt-Northwestern-Texas-Harvard
• PI Thomas Harris
• Vanderbilt University
• 10.3 million over 5 years

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VaNTH ERC

• Objective
• Experiment with the time proven NSF ERC model for
  research management and integration of research
  into curricula to determine if the ERC model is
  an effective mode to apply to develop new
  curricula for engineering, in this case,
  bioengineering.

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Other ERCs Focused on Biology

• All involve teams of engineers and biologists,
  sometimes also chemists and clinicians

• Biomimetic Microelectronic Systems (USC)

• Engineered Biomaterials (U. of Washington)

• Engineering of Living Tissues (GA Tech/Emory)

• Computer-Integrated Surgical Systems (JHU)

• Bioprocess Engineering (MIT)

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NSF Biologically-Oriented Engineering Proposals
are both Solicited and Unsolicited

• More Examples of Solicited
• Metabolic Engineering
• MUSES/BE (Materials Use Science, Engineering,
  and Society)
• Quantitative Systems Biotechnology (QSB)
• Biosystems at the Nanoscale (part of NSE)
• Examples of Unsolicited (PI-initiated)
• Biomedical Engineering
• Biochemical Engineering
• Bioenvironmental Engineering

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Example UnsolicitedBiochemical Engineering

• Summary - Addresses problems involved in
  economic processing and manufacturing of products
  by effectively using renewable resources.
• Funding Several million dollars per year.
• Program Contact Fred Heineken, 703-292-8320

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Example SolicitedMetabolic Engineering

• Explicitly cited as an area for research support
  in the Biomass Research and Development Act of
  2000
• Sec. 307. Biomass Research and Development
  Initiative
• (d) Uses of Grants, Contracts, and Assistance
• (2) research on technologies
• (A) metabolic engineering of biological
  systems...to produce novel products, especially
  commodity products, or to increase product
  selectivity and tolerance, with a research
  priority for the development of biobased
  industrial products that can compete in cost and
  performance with fossil-based products

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Another Solicited Example Technology for a
Sustainable Environment (TSE, with EPA)

• Summary - Funds fundamental and applied research
  in the physical and biological sciences and
  engineering that will lead to environmentally-beni
  gn methods for industrial processing/
  manufacturing.
• Example grant Biological hydrogen production
  as a sustainable green technology for pollution
  prevention (Logan, PA State U).
• Funding Approximately 6 million per year at
  NSF for all subjects.
• Program Contacts Bob Wellek (CTS), 703-292-8370
• Tom Waite (BES), 703-292-7499

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Another Solicited Example Materials Use
Science, Engineering, and Society (MUSES)

• Summary - Funds research on understanding the
  supply, treatment, use, and reuse of resources
  provided by natural systems as well as the
  environmental effects of introducing alternative
  materials or new processes.
• Example grant Developing Methods of Defining
  Sustainable Uses for Agricultural Products
  (Anex, U. of Oklahoma).
• Funding Approximately 6 million per year for
  all subjects.
• Program Contact Delcie Durham (DMII),
  703-292-8320

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Example QSB Grant

• NSF 0331342
• Reconstruction and Simulation of Genome-Scale
  Regulatory Networks
• PI Bernhard Palsson
• Department of Bioengineering
• U. Of Cal. San Diego
• 433K over 3 years

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One NSE Theme Biosystems at
the Nanoscale

• Development of fundamental understanding of
• nanobiostructures and processes
• nanobiotechnology
• techniques for a broad range of applications in
  biomaterials, biosystem-based electronics,
  agriculture, energy, and health

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Example Exploratory Grant Biosystems
at the Nanoscale

• NSF 0303868
• Charge Writing for Nano-Assembly of
  Bio-Molecules on Artificial Surfaces
• PI Eniko Enikov
• Aerospace and Mechanical Engineering
• University of Arizona
• 90K for one year

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Annual CAREER Grant Competition

• Scope - Supports early career development
  (research and education components) of new
  Assistant Professors, including those in the
  engineering and biology area.
• Grant Amount Typically 400,000 total over 5
  years
• Example Engineering and Biology CAREER Awardee
• Jennifer Becker
• Assistant Professor
• Biological Resources Engineering Department
• University of Maryland College Park
• Program Contact - Cindy Ekstein (BES),
  703-292-7941

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www.nsf.gov

• Is the URL for information on
• program descriptions
• program announcements
• solicitations
• grant summaries
• contact information