Multidisciplinary Clinical Research Career Development Program MCRCDP An Overview

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Multidisciplinary Clinical Research Career
Development Program (MCRCDP)An Overview

• Eugene P. Orringer, MD,
• Professor of Medicine
• Executive Associate Dean for
• Faculty Affairs and Faculty Development
• UNC School of Medicine

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UNC Multidisciplinary Clinical Research Career
Development Program

• Leadership of the UNC Program
• Eugene Orringer, MD Principal Investigator
• Morris Weinberger, PhD Co-Principal Investigator
• Susan Pusek, MPH Education Champion
• Bill Miller, MD-PhD Curriculum Director
• Rosalie Dominik, DrPh Director, Biostatistics
  Core
• Tricia Byrns, MD Program Evaluation
• Alison Regan Financial Manager
• Lowell Goldsmith, MD Program Ombudsman

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Multidisciplinary Clinical Research Career
Development Program

• An NIH Roadmap Initiative

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NIH Roadmap

• Dr. Elias Zerhouni initiated the NIH Roadmap
  Program soon after he assumed the NIH
  Directorship in 2002
• The Roadmap was designed to identify
  opportunities and gaps in biomedical research
  that no single institute at NIH could tackle
  alone, but that the agency as a whole needed to
  address.
• Dr. Zerhouni argued that NIH is uniquely
  positioned to catalyze the changes that must be
  made if we are to transform new scientific
  knowledge into tangible benefits for people.

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NIH Roadmap

• UNC has been a major beneficiary of the Roadmap.
  Through the end of FY 2006, UNC had received more
  Roadmap awards than any other single institution.
  
• 6 Roadmap Awards in 2004
• 8 Roadmap Awards in 2005
• 11 Roadmap Awards in 2006

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NIH Roadmap Data
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The NIH Roadmap
New Pathways to Discovery
Re-engineering the Clinical Research Enterprise
Research Teams of the Future
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Multidisciplinary Clinical Research Career
Development Program

• The MCRCDP was created as a key component of the
  NIH Roadmap. It was specifically designed to
  help
• Re-engineer the Clinical Research Enterprise
• Research Teams of the Future
• The MCRCDP has been funded using the
• K12 mechanism

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Multidisciplinary Clinical Research Career
Development Program

• What is a K12 Award?
• A K12 Award is a grant to an institution that is
  designed to provide protected time to a group of
  scientists committed to academic research
  careers.
• A K12 Award is very much like a training grant
  (i.e., a T32), but one that is designed for more
  senior level post-doctoral fellows and especially
  for junior faculty

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Number of Training Awards
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UNC BIRCWH Program

• Building
• Interdisciplinary
• Research
• Careers in
• Womens
• Health

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UNC BIRCWH Program

• UNC BIRCWH K12 Award began in September 2000
• This Grant brought us 5 years of NIH funding at
  500,000/year
• The vast majority of these s have been
  used to provide salary support to junior
  faculty members in exchange for 75 protected
  research time
• Based on the success of our program, we were
  able to compete successfully for a renewal of
  the BIRCWH Award in September 2005

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Multidisciplinary Clinical Research Career
Development Program

• When was the MCRCDP first established?
• The original RFA for this program was announced
  in late 2003 a second RFA was published by the
  NIH in late 2004
• The initial group of awards was made in the
  summer of 2004 the second group of awards was
  made in the summer of 2005

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Multidisciplinary Clinical Research Career
Development ProgramsWhat institutions were able
to compete successfully for MCRCDPs?

• Programs funded in 2004
• UCSF
• Mayo Clinic
• Case WR - Cleveland Clinic
• Johns Hopkins
• University of Washington
• University of Wisconsin
• University of Pittsburgh

• Programs funded in 2005
• University of Minnesota
• Washington University
• UT - Southwestern
• University of Maryland
• UNC - Chapel Hill

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Multidisciplinary Clinical Research Career
Development Programs

• What has happened since the creation of the
  MCRCDPs?
• Establishment of the
• Clinical Translational Science Awards
• (CTSA)

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Primary Objective of the CTSA Program Speed
Discoveries that will Improve Patient Care

• Develop a distinct discipline for clinical
  translational science at institutions across the
  country
• Provide opportunities and resources for original
  research on novel methods
• Develop translational technologies a knowledge
  base for the full spectrum of clinical and
  translational science
• Synergize partnerships with industry,
  foundations, and community physicians
• Train the multidisciplinary teams that will
  conduct the clinical and translational research
  of the future

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Clinical and Translational Science Awards (CTSAs)

• Lower barriers between disciplines
• Encourage creative, innovative approaches in
  solving complex medical problems
• Catalyze change break silos, barriers, and
  conventions

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NIH CTSA AwardsA Home for Clinical and
Translational Science
Trial Design
Clinical Research Ethics
NIH
Advanced Degree-Granting Programs
Biomedical Informatics
CTSA HOME
Industry
Participant Community Involvement
Clinical Resources
Biostatistics
Regulatory Support
Other Institutions
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Multidisciplinary Clinical Research Career
Development Programs

• One of the key features of competing successfully
  for a CTSA award is the establishment of an
  Education, Training, Career Development Program
• A K12 Program like the one described here is
  essential if a CTSA is to be successful

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Multidisciplinary Clinical Research Career
Development Program

• How is the MCRCDP structured?
• Each program includes a) a well-designed,
  didactic, educational core component b) a
  practical, hands-on, mentored clinical research
  component and c) a shared clinical research
  support facility
• Together, these three components are designed to
  provide CR Scholars with a broad experience in
  all aspects of the design, conduct, and analysis
  of clinical research

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What is meant by Clinical Research?

• In this K12 Program, clinical research has been
  defined to include the following areas
• Patient oriented research Research conducted
  with human subjects (or on material of human
  origin such as tissues, specimens and cognitive
  phenomena) for which an investigator directly
  interacts with human subjects. This area of
  research includes
• Mechanisms of human disease
• Therapeutic interventions
• Clinical trials
• Development of new technologies
• Translational research
• Epidemiologic and behavioral research
• Health services and outcomes research

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Multidisciplinary Clinical Research Career
Development Program

• What is meant by multidisciplinary?
• Each program is expected to include
  representatives from multiple clinical
  disciplines and other professions. Examples
  include
• Clinical doctoral degrees such as M.D., D.O.,
  D.D.S., D.M.D., D.V.M., O.D., D.C., Pharm.D.,
  N.D. with various specialties and subspecialties
• Non-clinical doctoral degrees such as DPH, Ph.D.,
  Sc.D., EdD from a wide variety of disciplines.

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How does multidisciplinary differ from
interdisciplinary ?

• A multidisciplinary approach brings together
  numerous experts from diverse disciplines to
  collectively address a complex problem, with each
  expert addressing the issues from the perspective
  of his or her own discipline.
• An interdisciplinary approach results from the
  melding of two or more disciplines to create a
  new (i.e., interdisciplinary) science.
  Biostatistics, bioinformatics, bioengineering,
  and psychoneuroimmunology are but a few examples
  of existing interdisciplinary sciences.

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Multidisciplinary Clinical Research Career
Development Program

• What are the overall objectives of this Program?
• Stimulate multidisciplinary clinical research
  training and education
• Enhance career development of postdoctoral
  fellows and junior faculty from multiple
  disciplines, specialties and subspecialties
• Establish a critical mass of national programs
  with a commitment to the development of a
  diverse, well- integrated, multidisciplinary
  workforce

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Multidisciplinary Clinical Research Career
Development ProgramThe UNC Program

• Based in all of the Schools on the Health Affairs
  Campus
• (Medicine, Public Health, Nursing, Dentistry,
  Pharmacy)
• Our Goals
• Select as Scholars both senior fellows and junior
  faculty
• Train these Scholars at a relatively early stage
  of research career
• Have a minimum of 3 disciplines represented each
  year
• Do our best to have all 5 schools represented
  within the program
• Recruit both women and underrepresented
  minorities
• Recruit both locally nationally Make the
  program a national resource

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UNC Multidisciplinary Clinical Research Career
Development Program

• Why was UNC selected receive this award?
• Strong, well-established research programs based
  in each of the five schools on a single,
  contiguous Health Affairs campus
• Long history of multidisciplinary collaboration
• Great success with multidisciplinary Centers,
  Institutes, Programs
• Excellent experience at UNC with the RWJ Clinical
  Scholars Program as well as with our K30
  several other NIH-funded K12 Programs
• Well-established partnerships with public and
  private sector entities (e.g., Glaxo, Icagen,
  NIEHS, Quintiles, RTI)
• Passionate commitment to the career development
  of junior investigators

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UNC Multidisciplinary Clinical Research Career
Development Program

• Leadership of the UNC Program
• Eugene Orringer, MD Principal Investigator
• Morris Weinberger, PhD Co-Principal Investigator
• Susan Pusek, MPH Education Champion
• Bill Miller, MD-PhD Curriculum Director
• Rosalie Dominik, DrPh Director, Biostatistics
  Core
• Tricia Byrns, MD Program Evaluation
• Lowell Goldsmith, MD Program Ombudsman

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UNC Multidisciplinary Clinical Research Career
Development Program

• Multidisciplinary Advisory Committee (MAC)
• Made up of senior investigators from all five of
  the Schools on the Health Affairs campus (over 15
  disciplines represented)
• Regular MAC Meetings - Responsibilities include
• Scholar selection
• Review, monitor and recommend changes in
  curriculum
• Monitoring and evaluation of the progress of
  each Scholar
• Monitoring and evaluation of the effectiveness
  of the program

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UNC Multidisciplinary Clinical Research Career
Development Program

• What comes with support from the MCRCDP?
• Support for salary starting in 2007, this is
  75 salary support up to 75,000 plus fringe
  benefits
• Support for research activities, travel,
  tuition and fees, books up to 25,000/year
• Support for Mentors 5,000/year for as many as
  two mentors per scholar
• Support from the Shared Biostatistical Core
  Facility

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UNC Multidisciplinary Clinical Research Career
Development Program

• What are our overall recruitment efforts?
• In July 2006 we recruited our first 6 Scholars
• In July 2007 we recruited 5 more Scholars
• In July 2008, we anticipate adding 5-6 additional
  Scholars
• Our goal is to recruit both
• Junior Faculty Members
• Senior Fellows (should be close to getting a
  faculty position)
• We intend to recruit Scholars from UNC from
  outside UNC
• In all cases, there must be a commitment for a
  faculty position from the Chair of the relevant
  Department

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UNC Multidisciplinary Clinical Research Career
Development Program

• The website for the MCRCDP is
• www.med.unc.edu/orfd/career-development-1/k12-road
  map
• The e-mail address for the MCRCDP is
• Kprograms_at_med.unc.edu

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