Fascinoma Rounds Group B streptococcus in ascitic fluid

1
Fascinoma Rounds Group B streptococcus in
ascitic fluid

• October 26th, 2005
• Sharmistha Mishra,
• Vanessa Allen,
• And with great thanks to Subash Mohan

2
Case 3 Group B streptococcus in ascitic fluid

• How common is GBS in peritonitis?
• What are the clinical implications of GBS
  peritonitis?

3
Risk Factors

• Cases associated with continuous ambulatory
  peritoneal dialysis (CAPD)
• Colonization of genital and anal tract
• Seven cases have been described previously and
  all had a very severe course

Liakopoulos V. et al. Clinical Nephrology.
62(5)391-6, 2004 Nov. Scanziani R. et al.
Nephrology Dialysis Transplantation.
14(9)2222-4, 1999 Sep.
4
Group B Strep Infection

• Seen in neonates and peripartum women
• In non -pregnant adults (2/3rds of cases)
• DM, Liver failure, RF, malignancy, AIDS
• Most often manifested as
• skin or soft-tissue infection
• bacteremia
• genitourinary infection
• Pneumonia
• Peritonitis
• 5-10 caused by strep spp.
• Most common is viridans streptococcus

5
Pathophysiology

• From GU source
• 10- 30 of pregnant women colonized
• Peritonitis secondary
• Severity of disease
• Secondary bacteremia

Farley MM, et al. N Engl J Med.
19933281807-1811.