Information Management

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Information Management
  The Challenges of Effective Patent Searching
for Biotechnology Information. Dr. Mark S
Burfoot 22/5/03 Information Management
Department Pfizer Global Research
Development Sandwich, Kent, CT13 9NJ
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Overview

• Information Management Department - Roles
  - Why do we do this? - Specialities
• Issues at Stake
• Biotechnology patent search strategy for a
  biological tool
• Databases used for searching
• Tools used in patent analysis

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IM Department

• Roles
• Information - collect and organise
• evaluate and analyse
• disseminate, protect and deliver
• Why do we do this?
• To enhance innovation and improve decision making
• Specialities
• Animal Health
• Biomedical - Literature based
• Intellectual Property (IP) Information Group
• Chemistry Consultants
• Biotechnology Consultants

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Structure
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LawSuit Costs

• Average cost of a patent infringement suit
  through trial in the US1.5million
• Source Ryan(1999)IP Summer conf., American Bar
  Assoc.,

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Biotechnology Issues

• Amgen Inc. and Transkaryotic Therapies Inc. (TKT)
• Amgen's version of EPO, Epogen, reaped nearly
  1.8 billion in sales in 1999
• Recombinant Versus endogenous issue at stake
• Enzo Biochem Vs Gen Probe.DNA probe to Neisseria
  gonorrhoeae.
• Written description deemed invalid as possession
  of claimed seq.s not proved

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Biotechnology Issues

• Festo and the Doctrine of Equivilence
• Nuffield Bioethics Committee

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Biotech Patents

• Reach through- EP0287653 (Salk Inst.)
• Use of compound identified with claimed screening
  assay
• US6410516-(harvard College)
• Method for inhibiting expression of a gene
  regulated by NFkB
• Gene claims- EP0764204 (HGS)
• In silico homology. Hu Oxayl-CoA decarboxylase
  having 50-60 homology to bacterial.
• Assay claims- EP1110639
• Assay to test for inhibitors of cytochrome P450
  (CYP2C9) and novel substrate

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ESTs

• Biotechnology Industry Organization
• (BIO), by the end of 1999 the PTO had issued
  2,330 patents

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Biotechnology Patent Search Strategy
Sequence Searching

• Identify sequence of biological tool using
  in-house databases
• - Swissprot/Trembl/GenBank

• Blast sequence against in-house Geneseq
  databases
• - Geneseqp and Geneseqfap
• - Geneseqn and Geneseqfan
• Also, external access to
• - Cas Reg
• - Identify homologous proteins/nucleic acids

• Identify key authors, keywords and synonyms

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Sequences
EMBL Database contained 38,743,873,166 bases in
24,759,744 records
21/03/03
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Organism top 10 based on nucleotide count
21/03/03
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Standard bioinformatic tools used for analysis
and in-house development
Illustrative example
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Multiple sequences within patents
Illustrative example
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Biotechnology Patent Search Strategy
Keyword Searching

• Compile a list of - keywords
• - synonyms
• - authors

• Generate a search strategy

• Databases - Registry
• - HCAplus
• - Derwent WPINDEX
• - Derwent Biotechnology Abstracts

• Use biological keywords / IPC codes to limit
  search

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Tools for Patent Analysis

• Patent Abstracts
• Derpict Software used to obtain Derwent Abstracts
• - read and analyse abstracts
• - identify relevant abstracts

• Patent Family Data
• Inpadoc used to obtain patent family data
• Identify WO, EP and GB patents
• Direct access to the EPO
• - up-to-date and accurate information

• Patent Document
• Download the patent from Micropatent/Patent order
• Analyse claims

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Tools for Patent Analysis

• Patent Status Information
• EPO Register to obtain the status of a patent
• Direct access to the EPO
• Up-to-date and accurate information and use of
  file register

• British Patent Office
• To obtain the status of a granted EP/GB patent

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Acknowledgements

• Information Management Pfizer
• EMBL
• Derwent

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Closing Statement
We never knowingly infringe granted patents