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Fitzpatrick Institute for PhotonicsDuke
University
Tuan Vo-Dinh
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Physical Facilities
Fitzpatrick Institute for Photonics Duke
University
Fitzpatrick Center for Interdisciplinary
Engineering, Medicine, and Applied
Science FCIEMAS 100M, 300,000-sqft
Facilities Dedication November, 2004
Fitzpatrick Institute for Photonics
(FIP) 120,000-sqft Facility 65 Faculty and
Research Groups 20 Departments at Duke
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Maintain Excellence in Current Core Competencies

• Biophotonics
• Nano and Micro Systems
• Quantum Optics Information Photonics
• Photonic Materials
• Advanced Photonic Systems

Strategic focus on target applications based on
competencies
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Develop New Competencies inSelected Target Areas

• Nanophotonics
• Systems Modeling Theory and Data Treatment
• Novel Spectroscopies

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Optical Coherence Tomography Joseph Izatt
Clinical Systems at Duke Medical Center Company
Spin-Off Optigen, Inc
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Breast Biopsy Needle Nimmi Ramanujam
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Fourier Domain Low Coherence Interferometry LCI
(fLCI) Spectral Characterization of Nuclear
MorphologyAdam Wax
Modality Mean Diameter Standard Deviation
fLCI 6.9 µm 0.8 µm
Confocal Microscopy 6.8 µm 1.1 µm

• Can determine longitudinal diameter of nucleus
  of cells in vitro
• Comparison of fLCI with confocal microscopy
  shows good accuracy

R.N. Graf and A. Wax,Opt. Express 13, 4693 (2005).
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Minimally Invasive In Vivo Cancer Diagnostics
Optics
Nitrogen Laser
Dye Module
Endoscope
Multi- channel Detector
Poly- chromator
Bifurcated Optical Fiber
PC
Clinical Trials Over 100 patients 98
Sensitivity 95 Specificity
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Halfshell Array as SERS Substrates

• Nanoparticle-based Substrate Parameters
• Nanoparticle material (e.g. alumina,
  titanium dioxide, polystyrene, fumed silica)
• Nanoparticle size (e.g. 50 nm- 500 nm)
• Metal (e.g. silver, gold, copper)
• Metal thickness (e.g. 50-100 nm)

Scanning electron micrograph of silver-coated
polystyrene microspheres
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Surface-Enhanced Raman Scattering (SERS)
Nanoparticle Probes

• Targeting molecules to be used will include
• Specific bioreceptors
• Antibodies
• DNA constructs that are complementary to a mRNA
  target sequence
• Enzymes

• Advantages of SERS-based labels
• Comparable sensitivity to fluorescence
• Resistance to photobleaching and quenching
• Enhanced spectral multiplexing (sharp lines
• minimal overlap)

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Nanosensor for Single-Cell Analysis
Fig. 8
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The Biochip Technology

• 2-D array of independently operating
  photodiodes
• On-board signal amplification and data
  treatment
• CMOS-based microelectronics integrated onto a
  single platform
• Coupled to compact sampling system

ADVANTAGES

• Compact design

• Microscale sampling capability

• Low power consumption

• Multiple assays possible on single platform

• Increased throughput

• Cost effectiveness

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Fitzpatrick Institute for Photonics Bridging the
Gap From the Nano World to Field
Devices Integrated Nano and Micro Systems

• Traditional Approach
• High Cost, Low Volume, Niche
• Separate Component Packaging
• Next Generation
• Low Cost, High Volume, Pervasive
• Integrated/Embedded OE Packaging
• Take OE packaging from discrete to integrated
  (emulating the IC revolution in the last 50
  years)
• Making tabletop systems into ladybug size

Nan Marie Jokerst, FIP
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Nanoparticle Plasmonics for Molecular DetectionA
A Lazarides, Duke University

• Objective Dsign and demonstrate reconfigurable
  plasmonic assemblies for use as sensors in
  optoelectronic detection systems and in cells
• Detection and Transduction
• Thermodynamic principles of soft matter assembly
  can be used to design self-assembling
  biomolecule-linked assemblies
• Reconfigurable DNA nanostructures can be designed
  to control interparticle separation and coupling
• Plasmonic sensors can be be integrated onto
  optoelectronic substrates or used as portable
  signallers in fluid biosamplese or cells

On/ off states of a chip fragment
BIomolecule-driven reconfiguration using DNA
nanostructures
Single assembly spectroscopy with Jack Mock and
David Smith
Spectrum predicted from structure
with T H LaBean
Microscopy
Spectroscopy
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Self-Assembling DNA Nanostructures Thom LaBean,
FIP, Duke University

• Biomolecular self-assembly.
• DNA building blocks.
• Organization of other materials.
• Photonic applications.
• Future directions and applications.

500 x 500 nm
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Negative e at Optical WavelengthsCloaking
MaterialsDavid Smith, Duke University

• Properties of Plasmons
• Surface modes
• Spatial variation of optical wavelengths on a
  scale ltltl.
• Large local field enhancements
• Large local density of states
• Contributes to SERS and SERRs phenomena
• Fast (fs) time scales

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Technologies for Integrated Nano- and
Micro-Systems

• Miniaturized systems containing
• Nanoprobes and microsensors
• Control and signal processing electronics
• Micro and nanofluidics
• Wireless alarm/data transmission
• Microactuators
• Integrate all of these components into a
• single mini-micropackage
• Patch, Probe, Stamp-sized
• Operates on a coin battery
• Continuous monitoring with pre-set alarm
  conditions and sensing information
• OR
• One shot sensing (disposable probes)
• Wireless data download

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Fitzpatrick Institute for Photonics
Faculty (March 28, 2006)
Fitzpatrick Institute for Photonics
Faculty (April 7, 2006)
Fitzpatrick Institute for Photonics Tuan Vo-Dinh,
Director
Biophotonics Izatt, Joseph, Program Director
Brady, David Johnson, G. Allan Provenzale,
James Ramanujam, Nimmi Shang, Allan Vo-Dinh,
Tuan Warren, Warren Wax, Adam
Advanced Photonic Systems Reichert, William,
Program Director Brady, Rachael Chakrabarty,
Krish Johnson, Kristina Edwards, Glenn Guenther,
Bob Massoud, Hisham Ozev, Sule
Nanophotonics Leong, Kam, Program Director
Chikolti, Asutosh Lazarides, Anne Liu,
Jie Smith, David Vo-Dinh, Tuan Wax,
Adam Yoshie, Tomoyuki
Nano/Micro Systems Jokerst, Nan , Program
Director Brooke, Martin Fair, Richard LaBean,
Thomas Massoud, Hisham Tian, Jingdong Yoshie,
Tomoyuki
Systems Modeling, Theory Data Treatment Yang,
Weitao, Program Director Beratan, David, Dwyer,
Chris Krolik, Jeffrey Liu, Qing Pitsianis,
Nikos Sun, Xiaobai Venakides, Stephanos
Quantum Optics and Information Photonics Gauthier,
Daniel, Program Director Baranger, Harold Kim,
Jungsang Thomas, John Warren, Warren
Photonic Materials Smith, David, Program
Director Brown, April Cummer, Steve Glass, Jeff
Jokerst, Nan Massoud, Hisham Stiff-Roberts,
Adrienne
Novel Spectroscopies Warren, Warren, Program
Director Brady, David Izatt, Joseph Palmer,
Richard Simon, John Vo-Dinh, Tuan Wax, Adam
Manager, Special Projects Guenther, Bob Manager, Educational Outreach Program Wax, Adam
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A Global Photonics VisionAn Initiative at the
New Frontiersof Science and Technology
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