Why direct thrombin inhibitors? The critical role of thrombin

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Why direct thrombin inhibitors? The critical role
of thrombin

• Thrombin is a link between vessel injury,
  coagulation, and platelet response

Platelet activation
Coughlin SR. Nature. 2000407258-64 Monroe DM
et al. Arterioscler Thromb Vasc Biol.
2002221381-9.
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Thrombin promotes platelet activation and clotting
Thrombin is a link between tissue injury,
coagulation, and platelet response
Platelet activation
Thrombin
Fibrinogen
Prothrombin
Platelet aggregation
Plasma clotting factors
Fibrin
Coughlin SR. Nature. 2000407258-64 Monroe DM
et al. Arterioscler Thromb Vasc Biol.
2002221381-9.
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