Life Analytical Chemistry-Molecular Imaging (MI): Magnetic Resonance Imaging (MRI)

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Life Analytical Chemistry-Molecular Imaging (MI)
Magnetic Resonance Imaging (MRI)
Gaolin Liang (???), Ph. D. Professor, Ph. D.
Advisor Department of Chemistry University of
Science and Technology of China Email
gliang_at_ustc.edu.cn http//lianglab.ustc.edu.cn
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History of MRI
Magnetic resonance imaging is a relatively new
technology. The first MR image was published in
197323 and the first cross-sectional image of
a living mouse was published in January 1974.4
The first studies performed on humans were
published in 1977.56 By comparison, the first
human X-ray image was taken in 1895.
2. Lauterbur PC (1973). "Image Formation by
Induced Local Interactions Examples of Employing
Nuclear Magnetic Resonance". Nature 242 190191.
doi10.1038/242190a0.  3. Filler AG (2010). "The
history, development, and impact of computed
imaging in neurological diagnosis and
neurosurgery CT, MRI, DTI". Internet Journal of
Neurosurgery 7 (1).  4. Lauterbur PC (1974).
"Magnetic resonance zeugmatography". Pure and
Applied Chemistry 40 149157. doi10.1351/pac1974
40010149.  5. Damadian R, Goldsmith M, Minkoff L
(1977). "NMR in cancer XVI. Fonar image of the
live human body". Physiological Chemistry and
Physics 9 97100. 6.Hinshaw DS, Bottomley PA,
Holland GN (1977). "Radiographic thin-section
image of the human wrist by nuclear magnetic
resonance". Nature 270 722723.
doi10.1038/270722a0.
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2003 Nobel Prize in Physiology or Medicine-MRI
Paul Christian Lauterbur (May 6, 1929 March 27,
2007) University of Illinois at Urbana-Champaign.
Chemist.
Sir Peter Mansfield (born 9 October
1933), University of Nottingham. Physicist.
Clive W.J. Granger, economic
Robert F. Engle III, Economic
Peter Agre, Chemistry, water channels
Nobel Prize in 1952 in Physics, NMR
Roderick MacKinnon, Chem,Ion channels
Alexei A. Abrikosov, Physics,superconduct
Anthony J. Leggett Physics,absent
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Basic Principles of MRI
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Basic Principles of MRI Proton
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Basic Principles of MRI Proton
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Basic Principles of MRI Proton
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Others 64-Gd 26-Fe 13-C 19-F 31-P
23-Na
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Basic Principles of MRI
FID
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T2 (SS0exp(-t/T2)
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T1 (SS0(1-exp(-t/T1)))
1/T1R1C1/T10
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Introduction- Principle of MR T1 contrast agent
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SPIO,???,Resovist
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NPs for MRI Inorganic crystals (SPIO)
Cunningham, C. H. Arai, T. Yang, P. C.
McConnell, M. V. Pauly, J. M. Conolly, S. M.
Magnetic Resonance in Medicine 2005, 53,
999-1005.
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NPs for MRI Nanaoparticle-assembled capsules
(NACs)
Plush, S. E. Woods, M. Zhou, Y. F. Kadali, S.
B. Wong, M. S. Sherry, A. D. Journal of the
American Chemical Society 2009, 131, 15918-15923.
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NPs for MRI Metal-organic-framework (MOF)
Rowe, M. D. Chang, C. C. Thamm, D. H. Kraft,
S. L. Harmon, J. F. Vogt, A. P. Sumerlin, B.
S. Boyes, S. G. Langmuir 2009, 25, 9487-9499.
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NPs for MRI Gadolinium liposomes
Ghaghada, K. B. Ravoori, M. Sabapathy, D.
Bankson, J. Kundra, V. Annapragada, A. PLoS One
2009, 4, Article No. e7628.
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NPs for MRI Emulsion nanoparticles
Flacke, S. Fischer, S. Scott, M. J. Fuhrhop,
R. J. Allen, J. S. McLean, M. Winter, P.
Sicard, G. A. Gaffney, P. J. Wickline, S. A.
Lanza, G. M. Circulation 2001, 104, 1280-1285.
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What we have done
Liang, G. L. Ren, H. J. Rao, J. H. Nature
Chemistry 2010, 2, 54-60.
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Our design and results
Liang, G. L. et al Rao, J. H. Angew. Chem.
Int. Ed. 2011, 50 6283-6286.
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Our design and results
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Our design and results
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Thanks for your attention!