BUSINESS OPPORTUNITIES IN BIOTECHNOLOGY IN INDIA

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BUSINESS OPPORTUNITIES IN BIOTECHNOLOGY IN INDIA

• P. K. Ghosh, Ph D
• Managing Director
• KEE GAD Biogen Pvt. Ltd., New Delhi
• (Former Adviser DBT, GOI)
• pkghosh_at_keepharma.com

March 06, 2009
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INDIAN EFFORTS TO SUSTAIN EMINENCE IN
BIOTECHNOLOGY MOSTLY A GOVERNMENT EFFORT

• Government Departments
• DBT
• DST
• DSIR
• DRDO
• DOE Others
• Autonomous Institutions
• CSIR
• ICAR
• ICMR
• UGC/AICTE Institutions
• Other Institutions

P. K. Ghosh
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INDIAN BIOTECH IN GLOBAL CONTEXT

• Publications and Patents filings on the rise
• Leadership in innovation is yet narrow
• RD Institutes Universities low in Global
  ranking
• Research in Industry not significant yet
• Innovation and Application not strongly linked
• Academia not ready to take risk for a venture

P. K. Ghosh
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HEALTH WEALTH INDEX FOR DEVELOPMENT

• A Country is highly developed if it has
• Break through remedies for major diseases like
• Cardiovascular diseases
• Cancer
• Viral Diseases
• Killer Bacterial Diseases
• Abundant availability of Clothing, Food
  Drinking water
• Sound Knowledge and Practice of good Hygiene
• High Quality Jobs
• Technologically Advanced Industries
• In all the above areas Biotech can make a
  contribution.

P. K. Ghosh
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SKILLS THAT REVOLUTIONIZED BIOTECHNOLOGY
Protein DNA Chips Microarrays
PCR Technology
Bio-Informatics
Microscopy and Imaging

• rDNAs MAbs

LC-MS MALDI-TOP
Chromatography Electrophoresis
Flow-cytometry Cell Sorting Techniques
P. K. Ghosh
Proteins Nucleotide sequencing
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TOP CONCERNS OF INDIAN BIOTECH INDUSTRY

• Scarce availability of leaders for company
  specific needs
• Inadequate availability of skilled work force
• Limited resources for research- Internal
  External
• Maintenance of Confidentiality
• Issues of Intellectual Property
• Bridging issues between RD Institutions
  Industry
• Demanding statutory requirements
• Biased concerns about products by opinion makers
  
• Limited linkage between Industry need Public
  research

P. K. Ghosh
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BENEFITS OF TECHNOLOGY TRANSFER BY RD INSTITUTES

• To push discovery into the market
• To attract Funding Industrial Partnership
• Budding skills can be placed into rewarding
  projects
• To earn rewards through income fame
• Obliged to be transparent by disclosers
  Projects, Employees, Sponsors etc.
• Economic development and Societal uplift

P. K. Ghosh
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GM- Planting Mats. Hybrids Micro-propagation
Bio-fertilizers Bio-pesticides Animal
Improvement
r-DNA Products, Vaccines Diagnostics
Monoclonal Antibodies Stem Cells Tissue Specific
delivery methods
Agriculture
Health Care
BIOTECH APPLICATIONS
Environment
Industry
Enzymes Fermentation based Products Food
Biotech Instruments Equipment Bio-energy
Bio-fuel Bioinformatics Bio-mining
Soil Water remediation Bio-safety GMOs
P. K. Ghosh
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BUSINESS OPPORTUNITIES HEALTH CARE

• rDNA Products MAbs
• Cloning, Cell multiplication, Product separation
  Formulations
• Choice of technologies
• Stem Cell Manipulation
• Isolation, purification multiplication of
  tissue specific stem cells
• Expertise in Cell re-programming to pluripotency
  
• Over expression of certain Genes for Cell
  re-programming
• Retro Non-retroviral means of over expression
  of target genes
• Tissue Specific Delivery Technologies
• Choice of Bio-degradable polymers modification
  methods
• Choice of technologies for production of precise
  Nano-particles

P. K. Ghosh
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BUSINESS OPPORTUNITIES AGRICULTURE

• GM- Seeds Varieties Hybrids
• Choice of right materials
• Cloning, Micro-propagation Field Testing
• Generation of Food Environmental Safety
  Information
• Extensive Public-Private Collaboration involving
  Opining Makers
• Animal Improvement
• Land Aquatic Animals Identification for
  Multiplication
• Choice of Exotic Animal germplasm
  Multiplication methods
• Feed Fodder Production technologies

P. K. Ghosh
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BUSINESS OPPORTUNITIES INDUSTRY ENVIRONMENT

• Industry
• r-DNA methods of producing Enzymes
• Fermented Food Beverages
• Software Development for use in Biotech
  operations
• Biotech Instruments through Electronics,
  Software New Materials
• Biomass Multiplication Bio-fuel
• Environment
• Biosafety Information generation for commercial
  use of GMOs
• Degraded/ Polluted Soil Water Remediation
  methods

P. K. Ghosh
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BIOTECH PRODUCT DEVELOPMENT TREND

• Drugs Pharmaceuticals for Human
• Isolating/Developing Multiplying Totipotent
  Stem Cells
• Genetically Modified Seeds for Agriculture
• Instruments for Biotechnology
• Bioinformatics

P. K. Ghosh
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Biotech drugs innovation process
Marketing feedback analysis
Strong Industry Motivation for Success
Production Unit setting up implementation into
valuable form
Phase I, II, III Studies
Marketing Strategy
Animal Studies
Actors
Money Spent
Pilot Development
Technology Development Transfer
Regulatory Approval
Proof of Concept
RD Institutes
New Idea/ Research
0
5
10
15
Time (Years)
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WHAT ARE THE SURVIVAL LANES?

• To Intensify Basic Research
• To Develop Novel Methods for Bio-generics
• Mass Production of Multivalent Vaccines
• Mass Production of Cheap Diagnostics
• Novel Drug Delivery Nanotechnology
• GM Varieties from Public Institutions
• Micro-propagation of elites
• Industrial Enzymes by r-DNA technology
• Mass Composting of wastes
• Enzyme Enriched Food Neutraceuticals
• Bio-energy Bio-fuels

P. K. Ghosh
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THANK YOU
Turbulence ahead
P. K. Ghosh