??Krill Oil(???????)

1
????????????????????????(2)
??????????

• ??Krill Oil(???????)
• ???????? Part 1

2
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December 2012
??????????
3
??????
?? Euphausia superb Dana, 1850 ?? ????????? ?? Ant
arctic krill

????????? ?6cm ,???????2g??????-50????????????????
??????????????????5-7?????????????????????????????
?????
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4
? ??????????????????????????????????(?????????????
? lt????????????????gt?? )
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5
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• ?????????? ????????(??20-40m,??80-190t
  )???4????8???????????????????

6
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• ??????????????????CCAMLR???????(48?????????)????
  ?????????????????????????????????????
• 09/10??(12?1?)???????211,974?? ? 179,132??
• (???)???????2011????200,000??????????
• ?????(2007????)???
• ???????????? (??23?????????????)
• ??????

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• ??????????????????????????? 2006?
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• ?????? ????????????????????????
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• ????????????????2008????????????????2011?????70
  ????2012 ????18????????????????????????Whole
  saler ???????????????????????75???????????????????
  ?????Health food store, Mass market, MLM
  internet sellers ???????
• ???????????? ??????????????1?? Dr.OZ Television
  show ?????????????????
• ????????????2011??????????????2009? 180??2010?
  ?330 ?? 2011 ? ?500 ??????????????????????????????
  ?????????2015??????2,500 ?? ????????????????
  

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• ???????????????
• ???????(???????
• ?????)?????????
• ?????
• ??????????

10
????????????????????????(2)
??????????

• ??Krill Oil(???????)
• ???????? Part 2

11
??????? ????????????????
?????????????????????(in vivo)
?????????? RD?????
12
lt??gt
??????????? 1.??????????????ORAC?
2.?????????????????
??????????? 1.???????(????????)?????
2.????????(?????????????2-AG)???
????????a????? ??????(PMS)???
13
?????????
??????(Euphausia superba)????????
?????????
???3-PC Omega-3 Phosphatidylcholine
???????DHAEPA
????????(??????)
14
lt??????????1gt
??????????????ORAC?
ORAC???? Oxygen Radical Absorbance
Capacity??????????????????? (USDA)??????????(Nati
onal Institute On Aging)?????????? ???????????????
????????????
ORAC value ( µmole TE/g )
Krill Oil ??????? Astaxanthin, Co-Q10, Fish
Oil, V.E. ???
15
lt??????????2gt
?????????????????
???????????????
????????
??????????????
16
lt??????????2gt
?????????????????
???????????????????????????????
?????????????????????????????????????????(???????
?????0.736µmol/g??) ???? ???(n6)?1??????100µL
?????6???????????????????????????HPLC?????
lt?????????????????gt
??? ??????????????? gt ????????? (Plt0.05)
??????? gt ????????? (Plt0.1)
??? ??????? ,??????????????? ?????????
(N.D.)
???? ??21???????????????? ???????????
(????) ?????????????????????????????????
17
lt??????????1gt
???????(????????)?????
???????????
???????????????????????? ???????????????????
Nature Medicine 2002
18
lt??????????1gt
???????(????????)?????
???????????????????????
???2060????(21)??????4??61? ????12??
Atherosclerosis. 2010 Apr209(2)520-3. Epub 2009
Oct 14. Administration of natural astaxanthin
increases serum HDL-cholesterol and adiponectin
in subjects with mild hyperlipidemia. Yoshida H,
Yanai H, Ito K, Tomono Y, Koikeda T, Tsukahara H,
Tada N. Department of Laboratory Medicine, Jikei
University Kashiwa Hospital, Chiba, Japan.
hyoshida_at_jikei.ac.jp
19
lt??????????1gt
???????(????????)?????
???3-PC???????????????
????????5???-PC2?????5???-PC2 ????OLETF???
6????4?????????
J Agric Food Chem. 2007 Aug 2255(17)7170-6.
Epub 2007 Jul 28. Effect of dietary omega 3
phosphatidylcholine on obesity-related disorders
in obese Otsuka Long-Evans Tokushima fatty
rats. Shirouchi B, Nagao K, Inoue N, Ohkubo T,
Hibino H, Yanagita T. Laboratory of Nutrition
Biochemistry, Department of Applied Biochemistry
and Food Science, Saga University, Saga 840-8502,
Japan.
20
lt??????????1gt
???????(????????)?????
????????????????????
1?610?????(?)?8??????????????????
Nutr Metab (Lond). 2011 Jul 138(1)51. Effect of
dietary krill oil supplementation on the
endocannabinoidome of metabolically relevant
tissues from high-fat-fed mice.
21
lt??????????2gt
????????(2-AG)???????
??????????????????
J Clin Endocrinol Metab. 2012 Jun97(6)E917-24.
Epub 2012 Mar 22. Hedonic eating is associated
with increased peripheral levels of ghrelin and
the endocannabinoid 2-arachidonoyl-glycerol in
healthy humans a pilot study. Monteleone P,
Piscitelli F, Scognamiglio P, Monteleone AM,
Canestrelli B, Di Marzo V, Maj M. Department of
Psychiatry, Second University of Naples, Largo
Madonna delle Grazie, 80138, Naples, Italy.
monteri_at_tin.it
?????????????2133???????8?????????????
???? (????????)
??? ??
UP
?????????????(2-AG) (????????)
22
lt??????????2gt
????????(2-AG)?????
?????????????????????
???????????????????????2-AG?????????
1?610?????(?)?8??????????????????
Figure 7 Levels of 2-arachidonoylglycerol (2-AG,
A) in the kidneys of high-fat fed mice with
dietary krill oil (HFKO) supplementation at
different doses (1.25, 2.5 and 5 wt). Data are
means SEM of separate determinations in N 4-5
mice. P lt 0.05 N vs HF P lt 0.05, P lt 0.01
and P lt 0.001 high-fat diet (HF) vs
HFKO1.25-2.5-5. N normal diet.
Nutr Metab (Lond). 2011 Jul 138(1)51. Effect of
dietary krill oil supplementation on the
endocannabinoidome of metabolically relevant
tissues from high-fat-fed mice. Piscitelli F,
Carta G, Bisogno T, Murru E, Cordeddu L, Berge K,
Tandy S, Cohn JS, Griinari M, Banni S, Di Marzo
V. Endocannabinoid Research Group, Istituto di
Chimica Biomolecolare, CNR, Pozzuoli (NA), Italy.
banni_at_unica.it.
23
lt??????????2gt
????????(2-AG)?????
Nutr Metab (Lond). 2011 Jan 308(1)7. Krill oil
significantly decreases 2-arachidonoylglycerol
plasma levels in obese subjects. Banni S, Carta
G, Murru E, Cordeddu L, Giordano E, Sirigu AR,
Berge K, Vik H, Maki KC, Di Marzo V, Griinari
M. Dipartimento Biologia Sperimentale, Università
di Cagliari, Cittadella Universitaria, 09042
Monserrato (CA), Italy. banni_at_unica.it.
????????????????????
2g/day???????(KO)???(MO)????????(OO)?4?????
24
lt??????????gt
????????(2-AG)?????
????????????????????
?????????????2-AG????????????
Figure 2. Endocannabinoid plasma levels (nM)
before (pre) and after (post) treatment with
different oils. norm normoweight subjects OW
overweight subjects OB obese subjects. B
arachidonoylglycerol (2-AG) respectively with
Krill oil (KO) treatment (n 7, n 5, n 9 in
norm, OW and OB respectively) D 2-AG
respectively with menhaden oil (MO) treatment (n
4, n 7, n 12 in norm, OW and OB
respectively) F 2-AG respectively with olive
oil (OO) treatment (n 4, n 7, n 8 in norm,
OW and OB respectively). Error bars depict
S.E.M. denotes statistical difference (p lt
0.05).
Nutr Metab (Lond). 2011 Jan 308(1)7.
25
lt???????a?????gt
Br J Nutr. 2001 Apr85(4)475-82. Changes in
nutrient intake during the menstrual cycle of
overweight women with premenstrual
syndrome. Cross GB, Marley J, Miles H, Willson
K. Department of General Practice, University of
Adelaide, South Australia, Australia.
crossg_at_mail.wch.sa.gov.au.
??????????????
???..
??????(Premenstrual Syndrome PMS)????
?????????????
26
lt???????a?????gt
???????PMS?????
??70??PMS?????????(35?)?????????(35?)?2g??90?????
Altern Med Rev. 2003 May8(2)171-9. Evaluation
of the effects of Neptune Krill Oil on the
management of premenstrual syndrome and
dysmenorrhea. Sampalis F, Bunea R, Pelland MF,
Kowalski O, Duguet N, Dupuis S. Department of
Experimental Surgery, University of Montreal,
Montreal, Quebec, Canada. tina.sampalis_at_sympatico.
ca
27
??????? ????????????????
lt?????gt
lt??gt
??????????
??????????
????????????
????????? (?????????)
?????????? (2-AG?)
????????????
a????????
PMS??
???????????
????a??
28
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?????? ?????(?3) ????(?4) ??????(?5)
?????? ?????(?1) ???????????(?2)
???????? ??????(?6)
???? ????????(?7)
?????????
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