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Supplementary Table 1
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... 1 Bortezomib CHOP C1 PARP C2 Bip Total-eIF2 XBP-1s Cleaved PARP Caspase 3 Cleaved Caspase 3 Cleaved Caspase 3 Cleaved Caspase 3 2 4 3 5 1 2 4 3 5 1 2 4 3 5 1 ... – PowerPoint PPT presentation
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Title: Supplementary Table 1
1
Supplementary Table 1
A.
CI simulations display synergism (CI lt 1),
additive effect (CI 1), or antagonism (CI gt 1)
for the entire spectrum of effect levels (Fa) in
the combination of NFV and BZ (right panel). CIs
for experimental values (left panel) are
displayed as actual Fa-CI plots in Figure 1B.
B.
CIs for experimental values are displayed as
actual Fa-CI plots in Figure 1D.
2
Supplementary Figure 1
RPMI8226
RPMI8226
DMSO
-
-
-
-
-
-
-
-
-
-
NFV
-
-
-
-
Bortezomib
-
-
-
-
Z-VAD
PARP
- Z-VAD
Cleaved PARP
Z-VAD
Percent sub-G1 DNA
Percent cell death
- Z-VAD
Z-VAD
DMSO
NFV
Bortezomib
NFVBortezomib
DMSO
NFV
Bortezomib
NFVBortezomib
3
Supplementary Figure 2
H157
4
Supplementary Figure 3
5
Supplementary Figure 4
A.
H157 Xenograft tumor lysates
NFVBortezomib
6
B.
H157 Xenograft tumor lysates
HSP70
7
C.
RPMI8226 Xenograft tumor lysates
8
Supplementary Figure 5
9
Supplementary Figure 6
