Alzheimer

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Alzheimers Disease
BRAIN, THE FINAL FRONTIER

• Kiminobu Sugaya, Ph.D.

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Alzheimers Disease
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Amyloid-b precursor protein
?-secretase
b-secretase
g-secretase
?-amyloid deposition
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Mechanism of Neurodegeneration in Alzheimers
Disease
APP
Glial Activation
Presenilin
Presenilin
Ab 1-40, 1-42
Neurodegeneration
Amyloid Deposition
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Glial Activation in Aging and Disease
Neuronal Dysfunction or Neurodegeneration
Glial Activation (Inflammation)
Shift
Shift
Age
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APOPTOSIS
APOPTOSIS
Phagocytosis and Degradation
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Fragmented DNA (Apoptosis) in the hippocampus
Aged Control
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Amyloid Plaque and Apoptosis
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Neuro-fibrillary Tangles and Apoptosis
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Astrocyte and Apoptosis


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GFAP mRNA Expression in the Aged Memory Impaired
Model Rat
Regression Analysis of GFAP mRNA Expression in
the Hippocampus against the Memory Score
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APP mRNA Expression in the Aged Memory Impaired
Model Rat
Ci/g tissue
Regression Analysis of APP mRNA Expression in the
Hippocampus against the Memory Score
Young
Aged unimpaired
Aged impaired
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Mn-SOD mRNA Expression in the Aged Memory
Impaired Model Rat
Ci/g tissue
Regression Analysis of Mn-SOD mRNA Expression in
the Hippocampus against the Memory Score
49.28 52.13 54.97 57.82 60.66 63.51 66.36 69.20 72
.05 74.89 77.74 80.59 83.43 86.28 89.12 91.97 94.8
2 97.66 100.51 103.35 106.20 109.04 111.89 114.74
117.58 120.43 123.27 126.12 128.97 131.81 134.66 1
37.50
Young
Aged unimpaired
Aged impaired
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APP ISHH with GFAP Immunostaining in the Aged
Memory Impaired Model Rats
Aged Impaired
matured
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GFAP ISHH (astrocytes marker) with 4G8 (Ab)
Immuno-histochemistry in PS1-APP TM
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APP ISHH with GFAP Immuno-histochemistry
(astrocytes marker) in PS1-APP TM