BORDETELLA

1
BORDETELLA

• K.V.PRAVEEN CHANDER

2
Important species

• Bordetella pertussis - Bordet-Gengou bacillus
• Bordetella parapertussis
• Bordetlla bronchiseptica - ancestral form
• Bordetella avium -causes respiratory
  disease in turkeys

3
(No Transcript)
4
(No Transcript)
5
(No Transcript)
6
(No Transcript)
7
(No Transcript)
8
(No Transcript)
9
(No Transcript)
10
Virulence
Steele, R.W. Pertussis Is Eradication
Achievable. Pediatric Annals. Aug 2004.
33(8)525-534
11
Adhesions

• Filamentous hemagglutinin
• Pertactin
• Fimbriae

http//www.rivm.nl/infectieziektenbulletin/bul1306
/kinkhoest.jpg
http//www.my-pharm.ac.jp/yishibas/research/Pertu
ssis1.jpg
12
Toxins

• Pertussis Toxin
• Adenylate Cyclase Toxin
• Tracheal cytotoxin
• Dermonecrotic toxin
• Heat-labile toxin

www.ibl.fr/u447/u447.htm
13
(No Transcript)
14
(No Transcript)
15
(No Transcript)
16
(No Transcript)
17
(No Transcript)
18
(No Transcript)
19
(No Transcript)
20
(No Transcript)
21
(No Transcript)
22
(No Transcript)
23
Pertactin

• Outer membrane protein antigen present in all
  virulent strains
• Included in acellular pertussis vaccine

24
Bordetella parapertussis

• Infrequent, cause of whooping cough
• Disease is mild
• Pertussis vaccine do not give protection

25
Bordetella bronchiseptica

• Peritrichate flagella
• Antigenetically related to pertussis and abortus
• Occurs naturally in the respiratory tract of
  several sps of animals

26
THANK YOU