Chapter 14.3 and 14.5: Fermentation and the Pentose Phosphate Pathway

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Chapter 14.3 and 14.5 Fermentation and the
Pentose Phosphate Pathway

• CHEM 7784
• Biochemistry
• Professor Bensley

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CHAPTER 14.3 and 14.5 Fermentation and the
Pentose Phosphate Pathway
Todays Objectives To learn and understand the

• Processes of fermentation under anaerobic
  conditions
• Oxidation of glucose in the pentose phosphate
  pathway

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Under Anaerobic Conditions, Animals Reduce
Pyruvate to Lactate
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Under Anaerobic Conditions, Yeast Ferments
Glucose to Ethanol
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Mechanism of Aldehyde Reduction by Alcohol
Dehydrogenase
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Pentose Phosphate Pathway

• The main goals are to produce NADPH for anabolic
  reactions and ribose 5-phosphate for nucleotides

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NADPH Regulates Partitioning into Glycolysis vs.
Pentose Phosphate Pathway

• NADPH inhibits glucose-6-phosphate dehydrogenase