Substance abuse prevention

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Substance abuseprevention

• Gilberto Gerra
• Chief
• Drug Prevention and Health Branch

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and vulnerability
Exploring resilience...
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Identifying risk conditions
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Biol Psychiatry Lasting epigenetic influence of
early-life adversity on the BDNF gene. Roth et
al., 2009 brain-derived neurotrophic factor
(BDNF) gene first postnatal week infant rats
exposed to stressed caretakers with abusive
behaviors persisting changes in methylation
of BDNF DNA that caused altered BDNF gene
expression in the adult prefrontal cortex BDNF
DNA methylation in offspring of females that had
previously experienced the maltreatment regimen
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Proceedings of the Naional Academy of Sciences
of the United States of America (PNAS), 2012
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Epigenetic effects of drugs
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Epigenetic mechanisms in drug addiction
Renthal and Nestler, 2009
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• Submitted twice or more times
• to epigenetic effects
• During the clinical history
• During the exposure to drugs

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Prevention of substance abuse reaching the most
vulnerable
Prevention of substance abuse as a pillar of
development and freedom
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