Transmitter Release

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Transmitter Release January 19th, 2005
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PNSIV F-14.1
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PNSIV F-14.2
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PNSIV F-14.4
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PNSIV F-14.3
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Spontaneous release(0.5mv) How many molecules?
Is the normal synaptic potential
quantized?
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PNSIV F-14.6
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• Katz and Miledi Hypothesis
• Transmitter quanta are stored in vesicles each
  containing about 5,000 molecules (ACh.)
• Vesicles are released at nerve terminal by
  exocytosis.
• Depolarization, increases release by increasing
  influx of Ca2 which in turn increases the
  probability of release by combining with release
  sites, allowing vesicles to fuse.

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PNSIV F-63.3
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PNSIV F-14.8
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PNSIV F-14.15
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PNSIV F-14.14
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PNSIV F-14.16
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PNSIV F-14.17
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PNSIV F-14.18
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