Cell Growth

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Cell Growth Differentiation Vol. 10, 545-554,
1999 Inhibition of the Jun Kinase Pathway Blocks
DNA Repair, Enhances p53-mediated Apoptosis and
Promotes Gene Amplification Ruth A. Gjerset,
Svetlana Lebedeva, Ali Haghighi, Sally T. Turla
and Dan Mercola
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Two independent experiment system
(1) MEFs Mouse Embryonic Fibroblast
p53 or -
DNA damage (Doxorubicin a drug used in cancer
chemotherapy)
(2) A lung tumor cell line derived from mice
expressing an oncogenic K-Ras mutation
(K-RasG12D)
p53 or -
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cre-lox recombination system
Cre-Lox recombination involves the targeting of a
specific sequence of DNA and splicing it with the
help of an enzyme called Cre recombinase.
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