Hyperthermia Applicator for Small Super?cial Tumour Treatment

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Hyperthermia Applicator for Small
Super?cialTumour Treatment

• Paolo TOGNI1 ,Jan VRBA 1 , Luca VANNUCCI2
• 1Dept. of EM Field, Czech Technical University in
  Prague
• 2Dept.of Immunology, Institute of Microbiology,
  Academy of Sciences of Czech Republic
• tognip1_at_fel.cvut.cz, vrba_at_fel.cvut.cz,
  vannucci_at_biomed.cas.cz

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Outline

• Introduction on experimental research
• Applicator design description
• Computer Simulation optimization
• Experimental evaluation
• In-vivo experiments
• Conclusions

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Research

• Microwave Hyperthermia as anti-cancer treatment
• Study morphological changes induced in
  superficial layers
• Immunological responses
• Melanoma in animal model

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Applicator Requirement
Model Characteristics

• Small tumour dimensions
• diameter 15-20 mm
• Limited deepness
• around 10 mm
• Small animal body
• Subcutaneous

• Focused Heating
• Limited E-field penetration depth
• Superficial Cooling

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Applicator Design (I)
Agar Phantom

• Planar Structure
• Squared resonant cavity
• Circular Slot-line radiating aperture
• Working Frequency
• 2450 MHz (ISM)

Water Bolus
Planar Applicator
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Applicator Design (II)

• Coaxial cable feeding
• Just TM mode can be excited
• Dominat Mode TM110

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S11 Parameter Evaluation

• Opimized using Computer simulator
• Cavity dimensions
• Slot line aperture Width
• Vector analzyer measurements
• Low Bolus thikness dependent
• High contact dependent
• Integrated bolus needed

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SAR distribution inside phantom

• Low Penetration Depth

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SAR distribution on phantom surface

• Tumour covering depends on bolus thickness
• 20 mm optimal thickness for our mouse model

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Temperature distribution measurements
10 - 12 mm

• IR Camera measurement
• Limited Temperature penetration
• Better results expected on
• animal model for the effect of blood perfusion

Without Water Bolus
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Temperature distribution measurements

• IR Camera measurement
• Effective Superficial cooling
• Reduced temperature penetration depth

10 - 12 mm

With Water Bolus
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System for Hyperthermia
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In-vivo Experiments

• Proper tumour temperature during treatment
• Suitable skin cooling
• Limited body temperature enhancement during
  treatment

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Conclusion

• Applicator suitable to treat small superficial
  tumours
• Suitable tumour covering
• Reduced enhancement of body temperature expected
• Suitable to used on surfaces with complex contour
• Perspective of clinical practice also in array
  configuration

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Thank you for your attention!
Acknowledgements This study is funded by the
Grant Agency of the Academy of Sciences of the
Czech Republic IAA500200510, Institutional
Research Concepts No. AV0Z50200510 and by the
Grant Agency of the Czech Republic, Grant
No.102/08/H081