Antigenic PowerPoint PPT Presentations

Microbial Pathogenicity Antigenic Variation & Vaccine Development Kevin Coombs kcoombs@cc.umanitoba.ca Nucleic acid mutation rates Chromosomal DNA 1: 1010 - 1011 DNA ...

Recombination, Phase Variation and Antigenic Variation Why Recombination? Homologous Recombination General Recombination often involves a Holliday Junction Proposed ...

What drives antigenic drift in a single influenza season? ... DIMACS Workshop on the Epidemiology and Evolution of Influenza Rutgers University, January 26, 2006

Frequency of recombination between two sites is proportional to the distance between the sites. ... Tsetse fly. Rabbit 1: A B C D E etc. Rabbit 2: A B D E etc. ...

Antigenic Shift v. Drift in Avian and Mammalian Sino-Influenza Type A Viruses. By Charles Hauser, St. Edward s University Mark Maloney, Spelman College

The Body s Defense Against HIV-Type 1 Infection, Viral Load, and Antigenic Diversity Emmanuel Jean-Jacques Seminar 475 Dr. Peter Lin Progression of AIDS Most ...

But at the moment we only have one time-point per subject. 4 ... NetMHC predicts CTL epitopes based on experimental binding affinity of peptides ...

Viruses that evolve in macaques infected with an M-tropic, NSI SIV clone derived ... co-cultivating in stimulated macaque peripheral blood mononuclear cells (PBMCs) ...

Theoretical and practical aspects of flaviviral antigenic structure in ... Mammalian tick-borne virus group (TBE, POW) Seabird tick-borne virus group ...

P. Mistry O. Parsons A. Prashar K. Wright. www.pnas.org/content/100/15.cover-expansion ... Can phosphorylation increase peptide binding affinity for HLA-A2? ...

Figure 22. Six MAX peptides represent 2 antigenic types. Results of ELISA tests measuring. the binding affinities of antisera against six MAX variants show that ...

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Chapter 4 Antigens and Antibodies Ab Ag Complementarity of interacting surfaces of Ab and Ag Oct 17, 19 & 24, 2006 Antigenic determinants on Igs 3 Antigenic ...

... Systems Initialisation Antigenic presentation Affinity evaluation Clonal selection and expansion Affinity maturation Metadynamics Cycle Clonalg For each ...

Antigens Immunogen a molecule that specifically interacts with an antibody or lymphocyte and elicits an immune response Antigenic determinants (epitopes)

Chapter 10 Forensic Serology * * Antigens * Antigens Chemical characteristics Proteins Larger than 10,000 mw Epitopes or antigenic determinants Multivalent antigen ...

Micro organism have either pathogenic or symbiotic ... genes include enzymes that modify the antigenic structure of surface molecules, ...

Innate Immunity. Adaptive Immunity(acquired) Cell Mediated Immunity (CMI) Humoral Mediated Immunity (HMI) Type of Immunity ... Epitope (Antigenic determinant) ...

1. Antigen-presenting cell (APC) phagocytizes and processes antigen. Allergen (antigen) ... Allergen (antigen) TH2 cell. APC presents antigenic determinant to TH2 cell ...

... protein in an individual is much smaller than the potential antigenic repertoire. ... from a common primordial gene encoding the basic domain structure' ...

The expression of antigen receptor genes is the Key event in lymphocyte Development/Maturation ... Before Antigenic Exposure. How to code for different antibodies? ...

Edward Jenner developed the modern practice of vaccination when he inoculated ... B) and acellular vaccines (antigenic fraction pertussis or whooping cough) ...

C3b initiates formation of a membrane attack complex (MAC) ... Haptens are found in poison ivy, dander, some detergents, and cosmetics. Antigenic Determinants ...

C3b initiates formation of a membrane attack complex (MAC) ... Haptens are found in poison ivy, dander, some detergents, and cosmetics. Antigenic Determinants ...

... R on T and B cells ... Each B and T cell has receptor that is unique for a particular antigenic ... Lag in adaptive immune response. Discrimination between ...

Adenoid. Tonsil. Thymus. Lymph. node. Spleen. Lymphatic. vessel. Peyer's. patches. in small ... Agglutination (clumping of antigenic cells) and precipitation ...

Define laboratory diagnosis of HIV infection. Understand different HIV antibody assays ... The tests differ in antigenic targets and methodologies ...

Lymphocytes B cells Respond to cell-free and plasma membrane-bound antigens ... they can recognize and respond to a large number and types of antigenic domains. ...

To compare and contrast immunogen, antigen & hapten ... Some glycolipids and phospholipids can be immunogenic for T cells and illicit a ...

Title: Gram Reaction Subject: Gram staining Author: Hugh Fackrell Last modified by: Hugh B. Fackrell Created Date: 10/18/1996 12:08:06 PM Document presentation format

Title: Author: lingzhang Last modified by: xiaowuhong Created Date: 11/10/2000 8:17:50 AM Document presentation format:

Substance that can be recognized by immunoglobulin receptors of B cells and T ... Gell and Banacerraf (1959) compared humoral and cell mediated responses to ...

Chapter 4 Antigen Definitions of antigen Antigen: non-self substances which can combine with TCR or BCR or Ab and have the potential of inducing immune response .

Title: Chapter 2 Antigen Author: Jiaxin Wang Last modified by: walkinnet Created Date: 3/14/2005 2:58:16 PM Document presentation format:

Antigen Foreignness and specificity of antigen Factors that influence immunogenicity Classification of antigen Nonspecific stimuli for immune response ...

... agglutination test done with a soluble antigen coated onto a particle Agglutination/Hemagglutination Inhibition Definition - test based on the inhibition of ...

Antigen Processing and Presentation Cytosolic (endogenous) pathway Endocytic (exogenous) pathway Ag processing: degradation of proteins into peptides

Cadherin family E- cadherin----- Epithelia cell N- cadherin ... (glycosylation dependent cell adhesion molecule-1) PSGL-1(P-selectin glycoprotein ...

Title: Slide 1 Author: H00MAN Last modified by: acadpm01 Created Date: 9/18/2006 6:47:29 PM Document presentation format: On-screen Show (4:3) Company

They are often associated with staphylococcal products and are involved in enterotoxemia and toxic shock syndrome in humans. Superantigens (SAgs) ...

The macrophages engulf invaders and debris and are responsible for most of the healing. ... When the body encounters an antigen for the first time, a primary ...

Chapter 4 Antigen(Ag * * * * * * * * * * * Functional determinant: epitope existed on the surface of Ag which can be recognized by BCR or combined with Ab easily.

Lymphoid malignancies include lymphocytic leukemia and lymphoma, which are tumors that occur on lymphocytes such as B cells, T cells, and NK cells. At present, there are many difficulties in its treatment, which are related to the recurrence and refractory of the diseases in the clinic. In the past 10 years, great progress has been made in the clinical treatment of lymphatic system tumors. Anti-CD20 monoclonal antibodies have been widely used in CD20-positive B-cell non-Hodgkin's lymphomas, and have achieved good results, becoming the first-line clinical application. However, since the cell surface of lymphoma and acute-chronic lymphocytic leukemia often has only CD19 antigen, an anti-CD20 antibody such as rituximab has no obvious therapeutic effect on it, therefore there is an urgent need for a new treatment method to improve the cure rate of lymphoma and acute and chronic lymphoma.

... each clone only bears a unique type of Ag receptor The clones of lymphocyte that can recognize self-Ags will be destroyed or learn to tolerance to self Ags ...

Immunogens Or Antigens Immunogens or Antigens Immunogen or antigen: * A foreign substance, when introduced into ...

Agglutination test It is one of important laboratory method to detect antigen antibody reaction. ... for semi quantitating of either antigen or antibody ...

Chapter 5 Antigen Presentation to T Lymphocytes Review: Two antigen-specific receptors: the TCR and the BCR. TCR sees antigens that were inside cells and that ...

Trends in Biotechnology Week 13 Immunology and some uses * * The B cell uses its antibody-receptor to bind a matching antigen, which it then engulfs and processes.

Immunogen vs Antigen. immunogen induces immune response. antigen reacts with ... plasma: collect with anti-coagulants, remove cells (ie, centrifugation) ...

Defends against antigens and pathogens in body fluids (humors) Figure 22 ... memory cells already primed. What is the structure of. an antibody, and what types ...

Antigen-Antibody Reactions Antigen-antibody interactions: Are reversible specific non-covalent biochemical reactions: Hydrogen bonds (A chemical bond in which a ...

Antigens (foreign cells and molecules) ~ viruses ~ bacteria ...

Incomplete Freund's adjuvant-oil-in- water emulsion. Complete Freund's adjuvant-oil-in-water emulsion plus dead Mycobacteria. Aluminum hydroxide gel ...

Proliferation and antibody production. No proliferation ... with hydrophobic C termini. TAP-1. TAP-2. Peptide. TAP-1. TAP-2. Peptide. TAP-1. TAP-2. Peptide ...

Immunogen- Substance capable of generating a specific immune response and ... 1000-6000D May or May not be ... Continuous/Linear-Single polypeptide segment. ...

Addition and Deletion of Nucleotides. Diversity of the Hypervariable region 3 (CDR3) ... Deletions. Additions. Terminal deoxyribonuceotidyl transferase (TdT) ...