Chemokines PowerPoint PPT Presentations

Epithelial tumour cells produce inflammatory cytokines, such as tumour necrosis factor- (TNF- ), and chemokines, such as CCL2 and CXCL12.

Inflammation and Chemokines Robert Beatty MCB150 Acute Inflammation Initiation of Acute Inflammation Vasodilation Increase in the diameter of blood vessels.

Expression of Specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients By Esther Valbrun Sorensen, TL et al. 1999.

indicated a significant linear relationship between CSF cell count and IP-10 concentration ... Dictionary of Cell and Molecular Biology. Sorensen, TL et al. 1999. ...

Comparison of cellular activities induced by lysophospholipids and chemokines in ... PTX pretreatment. Wortmannin (WM) pretreatment ...

Elements of the Immune System Cells of the Immune System Chemical Mediators Cytokines, Chemokines, Complement, Eicosanoids Apoptosis Acute Phase Response

CHEMOKINES are often first sign that host is infected ... Cutaneous immune system: keratinocytes, Langerhans cells and T-cells ...

Leukocytes Polarize in Gradients of Chemoattractants, then Crawl to the Source. Resting ... Endogenous antagonistic chemokines. Decoy receptors (Duffy, D6) ...

Organogenesis of secondary lymphoid tissues (SLT). Cytokines, chemokines and cell adhesion molecules. References. Mebius (2003). Nat Rev Immunol., 3, 292.

Elements of the Immune System Cells of the Immune System Chemical Mediators Cytokines, Chemokines, Complement, Eicosanoids Apoptosis Acute Phase Response

... matrix, growth factors, and proteases. Cytokines, chemokines, and antioxidants. Complement, immunoglobulins, and amyloid. Zuo F, et al. Proc Natl Acad Sci USA. ...

Multiplex assay is a procedure in which various analytes (such as proteins, biomolecules, growth factors, cytokines, and chemokines) are profiled by detecting and quantifying them simultaneously. This assay is used to amplify multiple targets in a polymerase chain reaction (PCR) and collect more information from minute quantities of proteins or other analytes in lesser time as compared to conventional methods such as ELISA. Multiplex assays are widely used for pathogen identification, mutation analysis, RNA detection, gene detection analysis, linkage analysis, and forensic studies.

... CXCL10/IP-10, CXCL11/I-TAC), two novel chemokines are implicated in sarcoidosis: ... (normalized to 1); the whiskers on each box represent the SD values. ...

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Lymphocyte recirculation

Excellence in phenotyping: Assessment of oxidative stress ... Department of Nephrology. Medical School Hannover. haller.hermann@mh-hannover.de. The problem: ...

Title: No Slide Title Author: Wieringa Last modified by: Wieringa Created Date: 6/30/2003 9:53:40 AM Document presentation format: On-screen Show Company

Interstitial lung disease (ILD) refers to a variety of diseases causing fibrosis in the lungs, leading to stiffness and difficulty in breathing and oxygen delivery to the bloodstream. This presentation gives an overview on "Treatment of ILD". For more information, please contact us: 9779030507.

Using size and charge characteristics to define co-evolution (correlation) ... The Markov process model (simulated evolution) Two states, A and a ...

Title: Chapter 7.cytokines(CK) Author: fan Last modified by: GUO Created Date: 3/10/2003 3:08:03 AM Document presentation format:

Inflammation Macrophages: arrive about 5-6 hours after an inflammatory response begins exhibit increased phagocytosis exhibit ...

Functional Anatomy of the Adaptive Immune Response Jason Cyster Describe the principal functions of spleen, lymph nodes, tonsil Explain how lymphocytes get from the ...

Cytokine X. soluble decoy receptors. soluble receptor antagonists. SOCS1 ... Vasculature. Memory T cell. Th1. T cell. APC. XC Chemokine Receptor. XCR1. XCRL1 ...

Type A (ab) Type B (ab or gd) Conventional MHC I & II Non-Conventional MHC ... gd TCR chains are determined by anatomic location. Mouse spleen: Vg1 & Vg4. Mouse ...

For cells to get from blood to lymphoid organ. or tissue they undergo extravasation ... proliferation and formation of scar tissue. Important cytokines: TNF- and IFN ...

Organ specific metastasis Breast cancer: lymph nodes, bone, liver, brain and lung Prostate cancer: lymph nodes and bone Colorectal cancer: liver

... A glycoprotein coreceptor that the HIV virus uses to infiltrate a macrophage ... The HIV virus requires coreceptors to infiltrate cells ...

Creative BioMart has a revolutionary new platform, which is designed for enrichment and highly sensitive detection of cytokine-secreting cells. Creative Biomart’s new platform enables the detection of inflammatory biomarkers in single and multiplex formats. As the next generation of electrochemiluminescence detection, Creative BioMart offers cytokine and chemokine assays that: have ultra-low detection limits. provide up to four logs of linear dynamic range. use minimal sample volume. handle complex matrices easily.

What controls recruitment of appropriate cell types (neutrophils, monocytes, ... across the subendothelial basal lamina and through interstitial tissues ...

WHO Collaborating Centre for the Characterization of Rabies and Rabies-Related Viruses ... Subdermal inoculation / hind footpad. 11d course (sampled at 0, 5, 11) ...

Medical Immunology 5. cytokine storm ...

Inflammation is a key pathogenic component in all of them, and anti-inflammatory ... recruitment of leukocytes that typifies diseases with an inflammatory component ...

University of Tabuk Faculty of Applied Medical Science Department of Medical Laboratory Technology Basic Immunology Mr.AYMAN.S.YOUSIF MSc.Medical Microbiology ...

They are involved in immunity and ... Th1 ( activate cell mediated immunity ) When Th1 cell get activated it will stimulate cell mediated immunity by IF ...

TRIF TRAM. NF- B TRIF MyD88. NF- B Inflammatory Cytokines. Interferon Pathway. Endosome ... TRIF TRAM. Inflammatory Cytokines. Pseudomonas. LPS. Yersinia. LcrV ...

Imunomodulacija-spolja nja regulacija imunskog sistema-

Signal Transduction Determines Cell Response APC TCR??? IL-2 What Happens When Ligands Bind to Receptors Conformational change of the receptors: Opens ion channel ...

NK-1R antagonists selectively inhibit HIV strains which use CCR5 ... Selectivity of NK-1R Antagonists for CCR5. Mechanism of Interaction between CCR5 and NK-1R ...

... by antibody First discovered Alternative pathway Activated by some bacterial cell surfaces Antibody not involved Lectin pathway Activated by mannose binding ...

Cardinal signs of (acute) inflammation. Rubor = redness. Tumor = swelling. Calor = heat ... Cellulits = acute skin infection commonly caused by Streptococcus ...

PCB4233: Immunology Dr. Mauricio Rodriguez-Lanetty Email: rodmauri@fiu.edu Phone: 305-3484922 Lecture 2 Special forces of high specialization Troop (library) of ...

Foundation Block, pathology INFLAMMATION AND REPAIR Lecture 4 Chronic inflammation Systemic effect of inflammation Dr. Maha Arafah Associate Professor

An ulcer : - Is a local defect, or excavation, of the surface of an organ or tissue that is produced by necrosis of cells and sloughing (shedding) of necrotic and ...

Epidemiological studies shown that inherited factors have ... HIV-1 infected Vs. HIV-1 noninfected. 3 genotypes tested. Allele frequency. Genotype distribution ...

The extra-intestinal manifestations of IBD Dr Allister Grant Consultant Hepatologist University Hospitals Leicester Gut Endothelium a4b7 a4b1 MAdCAM-1 VCAM-1 Flow CD3 ...

INFLAMMATION AND HEART DISEASE:

The humoral immune response accompanies papilloma regression, and is effective ... Humoral immunity is protective and is mediated by neutralizing antibodies to ...

Lymphocyte Activation Recognition David Straus dbstraus@vcu.edu Reading: Chpt 8-2, 8-3, 8-4, 8-11, 10-6 T cell activation: proliferation & differentiation Activation ...

Transdu o de sinal atrav s de subunidade comum. Explica: Redund ncia. Competi o ... Transdu o de sinal mediado por Receptores de Citoquinas ...

Serous (watery) Fibrinous (hemorrhagic, rich in FIBRIN) Suppurative (PUS) Ulcerative. BLISTER, 'Watery', i.e., SEROUS. FIBRINOUS. PUS. PURULENT. ABSCESS. POCKET ...

Title: Kuby Immunology 6/e Author: Kindt, Goldsby, Osborne Last modified by: sb Created Date: 12/24/2002 1:08:46 AM Document presentation format: On-screen Show (4:3)

Inflammation is a general term for the local accumulation of ... Humoral immunity. Allergy. IL-12. IL-4. Stat4. T-bet. Stat6. GATA-3. IL-6. TGFb. IL-23. STAT3 ...

A Closer Look at the interaction between CCR5 and HIV. Atchison RE, Gosling J, Monteclaro FS, Franci ... Immunoassay of CCR5-dependent cell entry by HIV-1 Ba-L ...

RAISON D'ETRE OF THE IMMUNE SYSTEM: To Distinguish Self ... in tissue parenchyma. Lymph nodes and the spleen provide. architectural support for cell-to-cell ...

ROLE OF GRANULOCYTES IN INNATE IMMUNITY. hematopoiesis. cytokines ... NOMENCLATURE OF COMPLEMENT SYSTEM. enhanced activation cascade principle ...

Chronic Inflammation and Mediators Duration of the process acute indicates a process that began recently chronic indicates a process with an extended time course any ...