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A tablet press is one of the most complex machines used in the manufacturing environment. Clearly defining the basic principles in tablet press operation is essential to having a successful run. Learning key factors can help to avoid the many obstacles that can interrupt a successful run. Worldwide, more than 18 different companies make tablet presses. All tablet presses operate in the same basic way with only a few exceptions. This fact allowed the industry to define and create a standard for tablet press machines and tablet press tooling, which was published in the Tablet Specification Manual (TSM) by the American Pharmaceutical Association. The TSM can be acquired through any tooling or tablet press supplier. This article discusses how tablet press performance can be optimized by clearly distinguishing between granulation and machine issues; focusing on the importance of flow, compression, and ejection; and performing the necessary maintenance and quality control checks.
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Tablet defects bedevil many manufacturers. This article outlines some strategies that tablet production experts use to resolve the most common ones, including weight variation, black spots, capping, and sticking and picking.
Tablet specifications are tight, and the list of possible defects is long: Variable weight, sticking, picking, black spots, streaks, capping, lamination, variable hardness, among others. This article focuses on variations in tablet weight and tablet hardness. It pinpoints the possible causes of these defects and offers advice on preventing and fixing the source of the problems. It also discusses the problems of formulations with too many fines.
Sticking occurs when granules attach themselves to the faces of tablet press punches. Picking is a more specific term that describes product sticking only within the letters, logos, or designs on the punch faces. This article explains the causes of sticking and picking and describes the steps you can take to resolve both problems.
High-quality coating begins with high-quality tablets, and no coating can achieve peak adherence unless all the tablets in a batch are uniform. When the substrate is prepared properly, tablet coating quality is predictable. A film coating won't hide tablet quality problems and will, in fact, likely magnify quality variations, even when they aren't extreme. This article discusses how variations in tablets - even when in the acceptable range - can affect film coating.
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The unit operations that precede tabletting are intended to make the powder ingredients work on the press. Granulating, milling, and blending are supposed to improve flow, compressibility, and ejection so that the powders can be controlled precisely to achieve accurate tablet weight, hardness, thickness, friability, disintegration, dissolution, and appearance. Recognize that the tablet press is the report card. It tells you how well you conducted the preceding unit operations.
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A tablet PC commonly known as tablet is a mobile PC. It typically comes with a mobile operating system i.e. android, LCD touchscreen display, and a rechargeable battery in a single-thin flat package. Tablets do what other PCs do, but dearth some I/O abilities that computer possess. Tablets have other I/O abilities that suits them to do their usual job.
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