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Unit 3A Human Form & Function Cells, metabolism & regulation Regulation of fluid composition Study Guide Read: Human Prespectives 3A/3B Chapter 8 Complete: RQ 10-14 ...
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Deamination of amino acids. serine. pyruvate. The first step is dehydration, in ... The amino acids serine and threonine can be deaminated directly ...
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uric acid. Glutamate plays a key role.... AA catabolism is by ... Note: uric acid = end-product. of purine catabolism in primates. as well as birds, reptiles ...
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By understanding how mitochondria get their dNTPs, we may understand the ... Before experimenting on yeast mitochondria, I will be experimenting on E.coli. ...
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O/F glucose No reaction for glucose with an alkaline reaction in the O-tube from protein de-amination ...
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The Mutability and Repair of DNA. The molecular basis of ... Deamination. Deamination. Depurination. Gene Mutation. The molecular basis of structural damage ...
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Mutation Point Mutations Spontaneous Depurination Deamination Oxidatitive damage Replication errors Trinucleotide repeat expansion and human disease
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aromatic, aliphatic, nitrogen. dealkylations(N-, S-, P) deaminations. N-, S-, P- oxidations ... aliphatic. aromatic. aliphatic. BIOTRANSFORMATION - NONSYNTHETIC ...
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Selective suppression of cytochrome P450 gene expression by the medicinal herb, ... Aromatic/aliphatic hydroxylation, oxidative dealkylation, deamination. Phase II ...
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represents a mutational hot spot through deamination of. methylcytidine to thymidine ... About 2,000 spots resolved per gel.good but not comprehensive. ...
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Rekha Abichandani, MD Medical Director, Clinical Research ... dAdo and its analogs. Resistant to Deamination. Resistant. to. Phosphorolysis. 20 Oct 2005 ...
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Can produce up to 38016 different protein isoforms. Pre-mRNA editing by Adenosine deamination ... Drosophila. genes. Pumilio domain (Wang et al, Cell, 2002) dsRBD-RNA ...
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Glycolysis, Bridging Rx, Krebs. NADH or FADH2. NAD /FAD. Oxidative Phosphorylation. ATP ... glycolysis b oxidation oxidative. deamination. Bridging Rx. Bridging ...
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Metamorphosis - how do they do it? Metamorphosis - how do they do it? Metamorphosis - waste products. Deamination. Protein breakdown. Ammonia - toxic. Uric acid ...
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Model studies in cell culture and ALS Tg mice and rats. WT and mutant SOD1 ... Hydro(pero)xy derivatives of aliphatic amino acids. Chloramines, deamination ...
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Several nucleotide bases undergo spontaneous ... Deamination of cytosine to uracil in DNA occurs approximately 100 times per day ... Ligation. Direct repair ...
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Two main types of DNA damage: *point mutations *structural mutations The molecular basis of point mutations 1. Base substitution transition transversion 2. Frame shift 3.
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B. Goitrous Cretinism D. Tyrosinosis. C. Albinism E. Alkaptonuria. Heme Catabolism. Heme to Bilirubin in liver to gall bladder to small intestine ...
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Title: PowerPoint Presentation - No Slide Title Author: Kirsten Norquay Last modified by: Bronwyn Carlisle Created Date: 3/9/2003 8:32:11 PM Document presentation format
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The Mutability and Repair of DNA Gamma radiation and X-rays Cause double-strand breaks in the DNA, which are difficult to repair. Ionizing radiation and agents like ...
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Title: PowerPoint Presentation Last modified by: Nagla Created Date: 1/1/1601 12:00:00 AM Document presentation format: (3:4)
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... Reliance on pedigrees Possible to determine sex linkage, ... Mutation rate depends on species and on gene Generally, mutations are random Hot spot: ...
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TRANSAMINATION In addition to being the basis of protein synthesis, amino acids form an important source of energy for the body. Animals do not have storage proteins ...
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DNA repair Direct repair Excision ... Depyrimidation 1.2 2,880 Oxidized DNA 10.2 24,000 Depurination 35.6 84,000 N7-MethylGuanine 50.9 120,000 Single-strand break ...
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Amino Acids: Disposal of Nitrogen
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Figure 25-29 The phosphopantetheine group in acyl-carrier protein (ACP) and in CoA. ... 'An electron pusher's delight: Cleavage of any of the aa's C bonds ...
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Dr. Parvin Pasalar Tehran University of Medical Sciences
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Review of Carbon Atom.
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Mutations Mutations are inheritable changes in the DNA Failure to faithfully store genetic information Changes can be to chromosomes or genes
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New System: Respiratory system. Part of the respiration/excretion unit Gas exchange and monitoring the air we breath Parts of the system Mechanics of breathing
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Chapter 13. Drug Metabolism Introduction: the process of drugs in the body includes absorption, distribution, metabolism and elimination. Drug metabolism is also ...
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Drug Metabolism By Dr. fatmah alomary Falomary@ksu.edu.sa
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Mutation, Transposition, and Repair
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... acids are those whose carbon skeletons can enter the Krebs cycle for energy production, or can form ketone bodies via ketogenesis for energy storage.
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Some Basics Nucleic Acid Structure Nucleic Acid Chemistry Other Functions of Nucleotides Fig. 8-12. X-ray diffraction pattern of DNA fibers. Intro. to Nucleic Acid ...
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Metabolism II Nearly all of the energy needed by the human body is provided by the oxidation of carbohydrates and lipids. Whereas carbohydrates provide a readily ...
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Title: Protein Metabolism Author: samy galal Last modified by: hp Created Date: 9/30/2006 6:09:35 PM Document presentation format: On-screen Show (4:3)
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Nonsense mutation---base pair substitution results in a stop codon (and shorter polypeptide) Frameshift mutations additions or deletions.
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DNA Replication and Repair Replication is bidirectional E. coli genome size = 4.6 X 106 bp Bacteria have circular chromosome with single origin of replication.
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Which AAs are ketogenic only? Glucogenic only? Both? Amino acid catabolism ... RED carbons: ketogenic. BLUE carbons: glucogenic. a-Ketoglutarate. Succinyl-CoA ...
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Kidney structure and function Biological principles in action Learning Outcomes 5.4.6 (a), (b) and (d). List main components of 3 body fluids Describe how to test ...
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Mutations and mutagens Transitions and transversions Causes of transitions Causes of transversions Errors in Replication Origin: spontaneous (naturally occurring) or ...
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Merriam Webster's Collegiate Dictionary. Helix (n) a. 'Something spiral in form. ... 10.5 bp/helix repeat. Helix diameter ~ 20 . 36 bp ...
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Chapter 7 Amino Acid Metabolism The biochemistry and molecular biology department of CMU Section 1 Nutritional Function of Proteins 1.1 The significance of ...
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HNPCC results from mutations in genes involved in DNA mismatch repair, ... The other strand of the duplex is displaced. Double-strand break repair ...
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DNA polymerase has 3' to 5' exonuclease function (epsilon-subunit) that ... Terminator utilization substance (Tus) binds to ter region. ...
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helps to stabilize p53) Homologous repair of DSBs. via recombination. Non-homologous end joining ... Nucleotide excision repair (to remove thymine-dimers after UV) ...
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DNA Mutation And Repair Base Mismatch Repair DNA polymerase proofreads itself, but makes an error every approx. 10,000-100,000 nucleotides (104 105) After repair ...
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Intestinal juice contain Carbohydrase, protease Vitamin C Deficiency disease Scurvy Vitamin A Deficiency disease Night blindness What is the fate of excess glucose?
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Methylation is catalyzed by enzymes in a cell. ... Methylation is usually confined to specific regions of DNA. and aid in biological processes. ...
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Title: Bacterial Genetics Author: g-max Last modified by: uoj Created Date: 10/16/2004 12:40:04 PM Document presentation format: On-screen Show Other titles
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Low rates of mutation can drive evolution. High rates of mutation can be catastrophic ... Mend the lesions and restore the original DNA. The Nature of Mutations ...
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The intron is removed in a Form Called a Lariat as the Flanking Exons are joined ... In this case the intron is linear rather than a lariat structure ...
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Nucleic acid chemistry part 1 : Some aspects of chemical and enzymatical modification of nucleic acids * * * * * * * * Reaction of guanosine with glyoxal (r = ribose ...
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