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GLYCOBASE
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Unit de Glycobiologie Structurale et Fonctionnelle, UMR 8576, ... Fucose CH3. Acetyl signals. CREDITS. Emmanuel MAES NMR engineer. Kevin THACKRAY Student ... – PowerPoint PPT presentation
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Title: GLYCOBASE
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GLYCOBASE ustl.univ-lille1.fr/glycobase/
Constitution of a database of O-glycan
standards E. Maes, K. Thackray, Y. Guérardel and
G. Strecker Unité de Glycobiologie Structurale
et Fonctionnelle, UMR 8576, Villeneuve dAscq,
FRANCE
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Study of glycoconjugate biodiversity
- Main models
- Amphibians
- Invertebrates
- Funga
- Bacteria
- Glycoconjugates
- N-glycans, O-glycans
- Free oligosaccharides
- Polysaccharides
- Lipopolysaccharides
O-glycans
- More than 400 new glycan structures described
- Many of them result from unknown activities
A. tigrinum
C. elegans
X. laevis
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Aim of glycobase
Put together all the O-glycans structures we
have described to make them available for
glycobiologists. Standards for structural work
Acceptor substrates for glycosyltransferases
Example
Study of a divergent (a1-4)Fucosyltransferas
e in Xenopus tropicalis Dr A. Maftah, Equipe de
Glycobiologie et Biotechnologie
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Present and future work
- Expend the base to all the species we have
studied - In collaboration with Dr K.H. Khoo (Academia
Sinica, Taiwan), systematic CID-MS/MS
fragmentation of our O-glycan collection - Include NMR database we are currently developing
- Based on the used of easily identified signals
- a and b anomers
- Fucose CH3
- Acetyl signals
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CREDITS
- Emmanuel MAES NMR engineer
- Kevin THACKRAY Student
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