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Heterotrimeric GProtein Signaling
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Charles Compton Lectureship. Ethan Marin '93, M.D., Ph.D. Yale University Medical Center ' ... Activation of the Heterotrimeric G-protein Transducin' ...
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Phosphatase: an enzyme which removes a phosphate group from ... T cell receptor signaling: NFkB activation. Cytokine signaling: Lymphocyte Programmed Cell Death ...
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Pertussis toxin (whooping cough disease) catalyzes ADP-ribosylation at a cysteine residue of Gia, making the inhibitory Ga incapable of exchanging GDP for GTP.
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Figure 2. Protein modules for the assembly of signaling complexes. Several modular domains have been identified that recognize specific sequences on their target ...
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Title: PowerPoint Presentation Last modified by: mlbvaj Created Date: 1/1/1601 12:00:00 AM Document presentation format: On-screen Show Other titles
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G-Protein Coupled Receptors (GPCRs) Lectures: February 28, March 2, 7, 9 and 11, 2005; Michael Greenwood (michael.greenwood@mcgill.ca) Nature Reviews Molecular Cell ...
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... AC Activation of Phospholipase C Initiates the IP3 Pathway IP3 Opens Calcium Channels on the ER and on the Tonoplast Cyclic ADP-Ribose ... Cyclic GMP ...
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... density dependant signaling Activation of Bio-film formation which affects bacterial resistance Extracellular Signals G Protein Coupled Receptors Guanyl ...
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Receptors and transduction mechanisms II Chapter 12 The Neuron by Levitan and Kacsmarek
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Title: Slide 1 Author: Jonathan Scholey Last modified by: Jonathan Scholey Created Date: 9/30/2006 3:00:19 PM Document presentation format: On-screen Show
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Rhodopsin: A specialized 7TM receptor mediating the visual cycle: ... Lysine-296 of rhodopsin forms a protonated Schiff base with 11-cis-retinal in the dark: ...
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Antidiuretic Hormone (ADH)/ Vasopressin Cell Communication By: Alejandra Ospina, Megan Campbell General Information ` Controls body water and solute concentration The ...
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... restores pathogenicity, appressorium development and cell surface hydrophobicity ... Lipid droplets stained with Nile Red. Upper =DIC. Lower ...
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Helix 6 is rotates while simultaneously elongating, comparable to a turning screw. ... The screwing motion of helix 6 may provide a mechanical trigger for ...
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Structural data on A. thaliana G. Meaningful comparison ... floral stems. floral buds and floral meristems. Localization (Weiss et al., 1997) plasma membrane ...
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14.3 Receptors sense diverse stimuli but initiate a limited repertoire of cellular signals ... The basic module is: a receptor. a G protein. an effector protein ...
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Protein destinations. Approx 10% of proteins cross at least the inner membrane. ... Lee VT, Schneewind O. Genes Dev. 2001 Jul 15;15(14):1725-52. ...
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Autonomic Nervous System: Introduction to neurotransmitter and receptor specificity Thomas Guenthner Professor of Pharmacology College of Medicine
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Biochemistry of Neurotransmission: A Type of Cell-Cell Signaling Biochemistry is fun Biochemistry of Cell Signaling Study Guide Contrast resting, ligand-gated ...
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Architecture of Megadalton Respiratory Proteins from Annelids
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horizontal, and amacrine cells), and retinal ganglion cells that ... Off-Center Pathway Causes Ganglion Cells to Stop Firing In Response to Light ...
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Cell signaling: responding to the outside world Cells interact with their environment by interpreting extracellular signals via proteins that span their plasma ...
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When the right signal comes along, it causes the release of ... Each subunit is made up of 4 transmembrane alpha helices (helical bundle). They are M1-M4 ...
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(3) transport to the target cells (4) detection of the signal by a specific receptor protein ... Have a common 7 transmemrbane 'serpentine' structure ...
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Result of ET method yields initial contact residues and putative binding surface ... Class specific residues cluster near putative PDE-y binding site ...
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a: antenna, p:maxillary. B:basiconic (L and S, ~200), T:trichoid, C:coeloconic. 1200 ORNs in antenna and 120 ORNs in maxillary pulp. Proneural genes in olfactory ...
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Lecture #7 Chapter 15 Cell signaling: Communication Between Cells and Their Environment Overview of intracellular signaling: Initiation and responses
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... glands (GH secreting tumors, acromegaly), and McCune-Albright syndrome. ... Acromegaly. The constellation of symptoms varies from one individual to the next. ...
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Chapt. 11 Cell signaling by chemical messengers Cell signaling by chemical messengers Student Learning Outcomes: Describe major chemical messengers used by cells
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What's Multiple Sclerosis (MS) First described by Charcot in 1868. ... In 1972, the association between multiple sclerosis and the HLA region of the ...
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ion channels let positive and negative charges diffuse through ... messing up G-protein signaling via toxins can cause diseases like cholera ...
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Title: PowerPoint Presentation Author: heringa Last modified by: gebruiker Created Date: 2/3/2003 6:56:45 PM Document presentation format: On-screen Show
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MAPs = Mt-Associated Proteins (not tubulin) that bind to MTs for their function. ... Mt polymerizing. toward kinetochore. (plasma membrane) ...
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The development of transgenic models, has been intensively used for ... If neurons are deprived of oxygen and the ATP stores drop, excess excitatory ...
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Title: PowerPoint Presentation Author: Valued Gateway Client Last modified by: computer services Created Date: 10/15/2001 5:49:13 PM Document presentation format
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Ga12/13 activates Src, Ras, phospholipase D and protein kinase C ... Ras is in active state when bound to GTP. When active it activates downstream effectors. ...
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Activated G proteins are short-lived because G also has GTPase activity (see ... Arg in Gs is ADP-ribosylated (from NAD ), activating adenylate cyclase. IV. ...
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CB201_12 Tim Mitchison Lecture 3 Force generation by polymerization dynamics Nucleation: controlling where and when polymers form
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Bioinformatics master course. DNA/Protein structure-function analysis and prediction ... http://www.few.vu.nl/onderwijs/roosters/rooster-vak-januari07.html ...
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Deletion of the Allele CKR5 Restricts HIV-1 infection and AIDS Progression By Laurel Kovach Dean, M., Carrington, M., Winkler, C., Huttley, G., Smith, M., Allikments ...
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... molecular clockwork within the SCN is being modeled as a combination of transcriptional and posttranslational negative feedback loops.
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Wnts bind to frizzled receptors, 7 TM spanning proteins. ... expressed RGS4 in Xenopus to see if it can attenuate a Wnt8 overexpression phenotype. ...
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Blastomere pair containing yellow crescent can form muscle when cultured in isolation -Muscle markers come on at appropriate time relative to control embryos ...
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Title: Anesthesia Author ***** Last modified by: DR.WALID Created Date: 3/1/2004 8:57:48 PM Document presentation format: On-screen Show (4:3) Company
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Inflammation Macrophages: arrive about 5-6 hours after an inflammatory response begins exhibit increased phagocytosis exhibit ...
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GPCRs and their effectors: signal transduction pathways and the cardiovascular system BIOM 200AB Nov
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The mating type pheromone, alpha factor, binds to a GPCR on the surface of an a ... In addition to the pheromone pathway, yeast have several other pathways that use ...
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structure calculations of protein surface segments: monte carlo simulated annealing with scaled collective variables and force constant annealing
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UNIT V Cell Signaling Part I ... Dimerization of STAT5 exposes a nuclear ... domain that affects its interaction with the second protein in the signal-transduction ...
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V4: Circadian rhythms (wrap up) Frequency distribution of expression fold-changes after sleep restriction relative to control. Filled area: Histogram of changes in ...
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Structure, function and mechanisms of G-Proteins. Oliver Daumke ... SN2 nucleophilic attack with trigonal bipyramidal transition state ...
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Steve Smith (Stony Brook) Yaoxing Huang (Aaron Diamond AIDS Research Center) Support: ... AMBER has good support for small molecules (GAFF) ...
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C. elegans Neurobiology
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Biology Department, Boston College, Chestnut Hill, Massachusetts ... the panel, a cell that has divided is shown, with two nuclei and a medial septum. ...
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