Immunogen PowerPoint PPT Presentations

According to Burnnet, Foreignness means substances which never contact with ... Foreignness. Size (Molecule weight) reasonable large molecule( 10.0 kd) has ...

Cadherin family E- cadherin----- Epithelia cell N- cadherin ... (glycosylation dependent cell adhesion molecule-1) PSGL-1(P-selectin glycoprotein ...

Na ve & pGT141 cured' BalbC mice. Splenocyte harvesting. Mix with JBS tumour cells ... pVivo is as effective as pGT141 in the delivery of immunogenes in a mouse model ...

Immunogens Or Antigens Immunogens or Antigens Immunogen or antigen: * A foreign substance, when introduced into ...

Some very small molecules called haptens can bind to Ab's or TCR's but they ... molecule that can be made immunogenic by conjugation to a suitable carrier ...

Immunogen vs Antigen. immunogen induces immune response. antigen reacts with ... plasma: collect with anti-coagulants, remove cells (ie, centrifugation) ...

Title: Slide 1 Author: H00MAN Last modified by: acadpm01 Created Date: 9/18/2006 6:47:29 PM Document presentation format: On-screen Show (4:3) Company

Endogenous: typically peptides derived from any protein; an infected cell ... Endogenous: these antigens are presented by MHC-I; they are seen by T-cells with ...

Bovine: BVDV, BHV-1, BPIV3, BRSV, rotavirus, coronavirus. Porcine: PRRSV, PRV, TGEV, rotavirus ... Cowpox, bovine rotavirus for pigs, turkey herpesvirus for chickens ...

... phase II prostate cancer vaccine trials (SIMMONS SJ Prostate 1999) 'ineffective ... GENE PROFILING OF BASAL CELL CARCINOMA TREATED WITH IMIQUIMOD REVEALS KEY ...

To compare and contrast immunogen, antigen & hapten ... Some glycolipids and phospholipids can be immunogenic for T cells and illicit a ...

CRM(197): inert but immunogenic variant of diphtheria toxoid ... Immunogenic and safe in infants ... higher coverages and immunogenic. S. pneumoniae. The vaccines ...

Even an immunogenic protein might have only one or a few epitopes ... Well-studied protein; known which regions are immunogenic. A Simple Self/Non-Self Predictor ...

Bovine serum albumin (BSA) = more immunogenic in chicken. than goat. Exceptions: ... animal from which they originated Immunogenic. 6. 2) Molecular Weight ...

Antigens Immunogen a molecule that specifically interacts with an antibody or lymphocyte and elicits an immune response Antigenic determinants (epitopes)

Vaccines containing capsular polysaccharide as immunogen are directed against : Streptococcus pneumoniae Haemophilus influenzae Neisseria meningitidis Salmonella typhi.

... expression; contact with the immunogen is immunization. ... Specificity- the mechanisms of acquired immunity are always highly specific to the immunogen. ...

False Negative Reactions with WIDAL Test Early treatment, Relapses of typhoid fever. Occasionally the infecting strains are poorly immunogenic.

An immunogenic tailor-made vaccine. Reactogenicity and safety profile ... Development of an immunogenic tailor-made vaccine to the specific. NZ sero subtype ...

Energy dependent, non immunogenic and potentially controllable process ... immunogenic and. not controllable. Necrotic cell debris - production of ...

... chocolate agar Serology inc. IgM during 1st week of illness; ... contains 5 purified antigens main immunogen is inactivated pertussis toxin; ...

overall assessment of product's immunogenic potential. possibility of generating cross-reaction ... Biologics more complex and frequently immunogenic ...

Chapter 4: Serology Concepts Serology Reagents Antiglobulins: Immunoglobins that are, themseves, immunogens Antiglobulins recognize a common epitope on the ...

... an isolated polypeptide that comprises an immunogenic fragment of SEQ ID NO: 1. ... binding the genus of polypeptides that comprise immunogenic fragments. ...

any research project that prospectively assigns human subjects to intervention ... HIV Immunogen not effective - company sued UCSF for $8M over publication; ...

Antigens, also known as immunogens, are toxins or compounds in our blood that cause our body to resist them for being foreign substances while Antibodies is Y-shaped proteins produced by B lymphocytes or B cells in our immune system.

Pulsing whole blood with overlapping peptides is highly T-cell immunogenic ... Immunogenic. Advanced development through non-human primates. No mouse model! Safe ...

... and many hormones, that are not immunogenic but are reactive when attached to protein carriers ... Only certain parts of an entire antigen are immunogenic ...

not usually immunogenic) 3. Chemical complexity. Homopolymers ... to degradation so they are not immunogenic. Large, insoluble molecules are more susceptible ...

MVA85A is as immunogenic in latently infected subjects as in BCG vaccinated subjects ... Safe and immunogenic in. M.tb infected adults (UK and South Africa) ...

Passive Antibody (IVIG, humanized monoclonal antibodies or immunotoxins) ... Recombinant antibodies are less immunogenic and induce less allergic reactions. ...

U.S. Emerging Lung Cancer Therapeutics ... Oncology Imclone Systems, Inc. Immunex Corp. Immunogen, Inc. Inex Pharmaceuticals Isis Ivax Corp. Millennium ...

Genetic control of the antibody response: Relationship ... Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 317:359-361. (1985) ...

Foreignness. Size. Conformational determinants. Sequence determinants. Chemical Composition ... Some glycolipids and phosopholipids can be immunogenic for T ...

Used in diagnosing the concentration of a variety of specific proteins and ... Ig's are immunogenic when used to immunize individuals of another species. ...

Cells in multicellular organisms are continually receiving signals ... Murine antibodies are limited clinically due to being immunogenic ...

Humoral and CMI: comparison. Specificity, memory, self-limitation. X-specifc ... Cellular and/or humoral. Composition of antigen/immunogen. Viral latency ...

Cell -Mediated Humoral (Ab) ... Structure Quarternary Structure Factors Influencing Immunogenicity Contribution of the Immunogen Foreigness Size Chemical Composition ...

600,000 Medicare patients are hospitalized using 4.2 inpatient days ... 'Influenza Vaccination is Safe and Immunogenic When Administered to Hospitalized Patients' ...

The B7/CD28 pathway is much more complicated than expected. Chambers C.A. et ... vaccines act synergistically to cause rejection of poorly immunogenic tumors. ...

... for the clinic and intended to be safe and immunogenic in HIV infants ... vaccines thus far appear safe and immunogenic as boosters in HIV individuals ...

Immunogen. Peptide. Epitope. B1. B2. B4. B5. B6. B7. B9. B11. SF162 ... Immunogen. Peptide. C2. C6. C7. C8. B C57BL/6. SF162. 89.6. MN. EDIISLWDQSLKPCV(6235) ...

Elastin-Like Polypeptides (ELPs) may serve as promising drug ... Non-immunogenic. Inverse Temperature Transition. Aggregates above Tt and solubilizes below Tt ...

Immunogen- Substance capable of generating a specific immune response and ... 1000-6000D May or May not be ... Continuous/Linear-Single polypeptide segment. ...

... by plasma cells in response to an immunogen and which function as antibodies ... Binding to various cells ???????? ???????? (Usually require Ag binding) ...

Infection typically grows in a wound found on a limb that has an anaerobic ... of C. perfringens; however, a it is difficult to prepare immunogenic toxoids. ...

Isolation of CMV-specific CD8 T cells. using peptide/MHC ... Many known immunogenic epitopes. Most frequent infection after allogeneic SCT (reactivation) ...

Via blood stream or extension form ears, sinuses. Intense ... Each identified in late 19th century. Known to cause a fatal meningitis ... immunogenic and ...

All phone lines closed initially. Question & answer period at end of presentation ... Influenza vaccine is immunogenic in hospitalized patients and patients with ...

To understand the advantages & disadvantages ... To become aware of the range of antimicrobials available ... Inert less immunogenic- may need frequent boosters ...

Vaccine technology has evolved significantly in the last decade. To accelerate response time to emerging threats, develop vaccines against difficult targets, Creative Biolabs offers a full range of vaccine design and production services. We combine the traditional and the most updated genetic engineering technologies to efficiently produce highly immunogenic vaccines addressing urgent unmet medical needs

Ribosomal recruitment can occur at m7G cap or internal ribosome entry site (IRES) ... by exposing individuals to DNA constructs expressing immunogenic antigens ...

20% relapse and develop metastatic disease involving lymph nodes (stage III) or ... Melanoma is inherently immunogenic. Anti-melanoma antibodies (Surgery 64:233, 1968) ...

... diseases, the immune system is primed' with an immunogen that stimulates a ... B and T Cells memory cells are primed by the vaccine and are waiting for the ...

Inhibition of Atherosclerosis in ApoE-Null Mice by ... Why does oxidized LDL become immunogenic? Fragmentation of apo B-100. Oxidation of phospholipids ...

... and, as such, it is consistently immunogenic is children under the age of 2 years. b) Aimed at protection against the leading cause of invasive bacterial ...