Interactions Of Meglitinides PowerPoint PPT Presentations

¢ Drug interactions of Meglitinides (Repaglinide & Nateglinide) are dealt in this presentation. ¢ Repaglinide is metabolized by the CYP3A4 and CYP2C8 and hence it interacts with Gemfibrozil, Azole antifungals, Dabrafenib, Montelukast, Macrolide antibiotics and Rifampicin. ¢ Nateglinide is metabolized by CYP2C9 (70%) and CYP3A4 (30%) and it interacts with Amiodarone and Macrolide antibiotics. It also interacts with NSAIDs, MAOIs, Trandolapril, Non selective beta blockers Thiazide diuretics, Corticosteroids, Danazol, Sympathomimetics, Phenytoin and St.John’s wort.

Drug interactions of Incretin mimetics (Exenatide) with other drugs like Warfarin, Digoxin, Paracetamol, Antibacterials, Thyroid hormones, Danazol and ACE inhibitors are dealt in this presentation. The interactions of Amylin analogue (Pramlintide) with other drugs such as Alpha glucosidase inhibitors, Danazol, ACE inhibitors, Thyroid hormones, Paracetamol and Antimuscarinics are also dealt in this presentation.

Diabetic patients take Insulin and/or other oral hypoglycemic and antihyperglycemic drugs to control their blood sugar levels. Along with antidiabetic medicines they may take drugs such as OTC medicines, prescription medicines, etc.to treat other illnesses which may interact with them. Drug interactions of Insulin with other drugs like Fluoroquinolones, Betablockers, Aspirin, Thiazolidinediones, Antipsychotics, Androgens, Antimalarials and Orlistat are dealt in this presentation. The interactions of Insulin with Complementary and alternative medicines (CAM) such as Bitter melon, Ginkgo, Ginseng, Gymnema, Licorice and Fenugreek with smoking and with alcohol are also dealt in this presentation.

Learn the horrible effects your diabetes medicine have on your health and also know the secret to avoid the medicines and take controll of your life.

Title: Acute Renal Failure Author: Johns hopkins Last modified by: Jessica Joseph Created Date: 7/30/2002 12:40:54 AM Document presentation format

Drug Safety in Chronic Kidney Disease Primary Care Clinician Conference 4/26/14 Michael J Choi, MD Johns Hopkins University School of Medicine mchoi3@jhmi.edu

Update in Diabetes Management Oral Therapies. Amy M. Lugo, PharmD, BCPS, CDM ... Use in premenopausal anovulatory women may cause resumption of ovulation ...

Side Effects. Decreased appetite, N/V, diarrhea. Toxicity. Lactic ... Side Effects. Flatulence, cramps, abd distention, diarrhea, borborygmus. Hypoglycemia ...

Sulfonylureas : stimulate cells to produce more insulin. 1st generation (1)Orinase (tolbutamide) (3)Tolinase (tolazamide) (6)Diabinese (chlorpropamide)

Postprandial. Glycosylated Hemoglobin. Glycosylated Albumin. 7. Glycosylated Hemoglobin ... For example, NSAIDs can cause erratic absorption of insulin ...

Frequency of diagnosed and undiagnosed diabetes and IGT, by age (U.S. data - Harris) ... Seattle Defibrillator Experience. GREACE Study. www.diabetesclinic.ca ...

Title: (Antidiabetis Drugs Insulin and Oral Antisiabetis Drugs) Author: Last modified by

has anorectic effect. low risk of hypoglycemia. don't lead to weight gain ... central anorectic effec. 2. Orlistat. inhibitor of intestine lipase. less ...

4. Describe the metabolic effects of insulin and the major ... 2. Understand the physiology of circulating insulin, C-peptide and proinsulin. ...

Diabetes Mellitus Normal Insulin Synthesis Prosinsulin is produced in the beta cells Before secretion, prosinsulin cleaved into Insulin Connecting peptide (aka C ...

Pharmacology of Hormones Endocrine Pancreas Martin Sterba, PharmD.,PhD. Dept. of Pharmacology Glucagon Polypeptide hormone (29AA) Secreted by pancreatic -cells ...

Antidiabetis Drugs Insulin and Oral Antisiabetis Drugs Department of Pharmacology, Peking Union Medical College Caiying Ye Overview diabetes mellitus A chronic ...

Diabetes Mellitus Definition: metabolic disorder characterized by hyperglycemia due to an absolute or relative lack of insulin or to a cellular resistance to insulin

... focusses on abdominal obesity rather than insulin ... Central obesity - waist circumference 94 cm for Europid men, 80 Europid women ... Mortality statistics ...

Thyroid hormones and antithyroid drugs Dept of Pharmacology Shi-Hong Zhang ( ) shzhang713@zju.edu.cn Thyroid hormones Hyperthyroidism Hypothyroidism cretinism ...

Insulin Rx Considerations Rotation within one anatomic site is preferred to moving from site to site. Abdomen provides best absorption Be alert to Dawn and/or ...

Review medical therapies for type 2 DM. List important considerations in ... Slow absorption of carbohydrates and reduces rise in postprandial glucose levels ...

In the 12 studies of kidney transplantation, ... peripheral tissue insulin sensitivity Related to the dose and the duration of therapy Calcineurin inhibitor ...

Based on 2 open-label trials, ... In other words, what percent of new users of each class (reading down), ... Probably closest to capturing true new diabetics ...

University of California, San Francisco-San Francisco General Hospital ... Side effects: flatulence, diarrhea, abdominal cramps, decreased metformin absorption ...

Diabetes Mellitus Overview and Treatments Andrew P. Vogt Chemistry 6116 Diabetes Mellitus : a group of diseases characterized by high levels of blood glucose ...

Life-Style Modification: Is it Important? Exercise ... Lifestyle ... Lifestyle measures should be the first action. Pharmacotherapy should have beneficial effects on ...

Metoprolol vs Toprol XL. Captopril TID vs Monopril QD? MS-Contin vs. immediate release/prn ... The contents presented do not necessarily reflect CMS policy. ...

Cardiometabolic Syndrome Dr. Nabil Sulaiman HOD Family and Community Medicine, Sharjah University and University of Melbourne & Dr Dhafir A. Mahmood

Diabetes Change Agent A National Pilot Program * * * * Amylin is absolutely or relatively deficient in DM Deficiency in amylin results in more fluctuations with blood ...

... fruit juice; 8 oz of skim milk, 3 glucose tablets, 3 life ... Some clients receiving high caloric feedings including tube feedings or parenteral nutrition ...

... fruit juice; 8 oz of skim milk, 3 glucose tablets, 3 life ... Some clients receiving high caloric feedings including tube feedings or parenteral nutrition ...

Diabetes Mellitus * Other complications: Gastrointestinal (gastroparesis, diarrhea) Genitourinary (uropathy/sexual dysfunction) Dermatologic infectious ...

Symptoms (polyuria, polydipsia, unexplained weight loss) plus casual ... Side effects: weight gain, pedal edema. Caution: CHF No more regular LFT Monitoring ...

BIOCHEMISTRY

Definition: Diabetes Mellitus Diabetes mellitus (DM) is a syndrome of chronic hyperglycemia due to relative insulin deficiency, resistance, or both.

R.A.Howland, M.J.Mycek: Lippincott's Illustrated Reviews: Pharmacology,3rd ed. ... The inner (zona reticularis) - adrenal androgens (e.g., dehydroepiandrosterone) ...

Biguanides are derivatives of the antimalarial agent Chloroguanide. ... Type 2 diabetes failed on diet ... Improves postprandial glycemia ...

Polydipsia. Polyphagia. Weight loss/increased appetite. Blurred vision ... Polyphagia, polyuria, polydipsia. Blurred vision. Fatigue. Sores that heal slowly ...

Hormones of the Pancreas bulk of the pancreas is an exocrine gland secreting Endocrine pancreas Scattered through the pancreas are several hundred thousand clusters ...

Endocrine System Chapters 21, 22, 23, 24, 26 Endocrine System Endocrine system regulates essential activities of the body Metabolism of nutrients Reproduction Growth ...

Clinical Exercise Physiologist (AEP, PhD) Centre for Ageing, Rehabilitation, Exercise and Sport (CARES), Victoria University ... Exercise Variables. Ratings of ...

Marked weight loss ( 10%) Type 1 first degree relative ... Inhibits gluconeogenesis. Stimulates peripheral glucose uptake. Enhances insulin receptor binding ...

2002.11.02. . . ... Hyun Ho Shin, M.D. Department of Medicine Samsung Cheil Hospital Sungkyunkwan Univ. School of Medicine

IV dextrose not required unless insulin is administered and patient NPO. Diabetes Management: ... Continue long-acting insulin while NPO and on IV dextrose ...

Rotten egg smell, rapid onset olfactory fatigue. Upper airway & pulmonary irritant ... All anti-anxiety agents have sedative properties, many are anti-convulsants. ...

Pramlintide strongly enhances the effects of prandial insulin, frequent SMBG and ... Prandial insulin can almost always be administered before meals in T2DM. ...

... insulin ratio Label reading is an essential skill ... disease is Depression Twice as common in diabetics than general population Anxiety Some evidence to ...

Economic Impact of the Clinical Benefits of Bariatric Surgery in Morbidly Obese Patients with Diabetes: An Observational Study Samuel Klein, M.D.;1 Arindam Ghosh, PhD ...